ID A0A3Q4NB13_NEOBR Unreviewed; 348 AA.
AC A0A3Q4NB13;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Acetylserotonin O-methyltransferase 2 {ECO:0000313|Ensembl:ENSNBRP00000031419.1};
OS Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000031419.1, ECO:0000313|Proteomes:UP000261580};
RN [1] {ECO:0000313|Ensembl:ENSNBRP00000031419.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q4NB13; -.
DR STRING; 32507.ENSNBRP00000031419; -.
DR Ensembl; ENSNBRT00000032215.1; ENSNBRP00000031419.1; ENSNBRG00000023867.1.
DR GeneTree; ENSGT00940000166228; -.
DR OMA; ENRRGPI; -.
DR Proteomes; UP000261580; Unplaced.
DR Bgee; ENSNBRG00000023867; Expressed in camera-type eye and 3 other cell types or tissues.
DR GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR031725; ASMT_dimerisation.
DR InterPro; IPR016461; COMT-like.
DR InterPro; IPR001077; O_MeTrfase_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11746:SF150; ACETYLSEROTONIN O-METHYLTRANSFERASE 2; 1.
DR PANTHER; PTHR11746; O-METHYLTRANSFERASE; 1.
DR Pfam; PF16864; Dimerisation2; 1.
DR Pfam; PF00891; Methyltransf_2; 1.
DR PIRSF; PIRSF005739; O-mtase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51683; SAM_OMT_II; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT DOMAIN 15..103
FT /note="Acetylserotonin O-methyltransferase dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16864"
FT DOMAIN 121..330
FT /note="O-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00891"
FT ACT_SITE 258
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005739-1"
SQ SEQUENCE 348 AA; 38909 MW; 274C6497EF898D10 CRC64;
MAEHMSQSEL DYPFKLLEYF NGFRVSKVIF SACELGVFDL LLRSQEPLSA QHVAQELGTS
LDGMERLLDA LVGIEILEVE KTDGTALYSS TDVANLYLAK GSAKSLHDMI VYKSQTIYPL
WNNLVDAVRS GKNQNEKTFG LPAEEVFQAI YRSEEDMLKF MGLMNSSWVL DGHDVVTAFN
LSGFQNVVDL GGCTGALARE MAKAYPSSTV TVFDLQQVVE AAQKHFSQEN DAIVFQSGDF
FTGEIPTADL YVLARIIHDW PEEKCLTLLK KIYDMCAPGG GVLLVEAMLF ENRRGPIMTQ
LFSLNMLVQT KGRERPPSEY THMFNKTGFK NIQVCRTGKS YDAILAIR
//
