ID A0A3Q7EN27_SOLLC Unreviewed; 953 AA.
AC A0A3Q7EN27;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN Name=101251225 {ECO:0000313|EnsemblPlants:Solyc01g096900.3.1};
OS Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC Solanum subgen. Lycopersicon.
OX NCBI_TaxID=4081 {ECO:0000313|EnsemblPlants:Solyc01g096900.3.1};
RN [1] {ECO:0000313|EnsemblPlants:Solyc01g096900.3.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Heinz 1706 {ECO:0000313|EnsemblPlants:Solyc01g096900.3.1};
RX PubMed=22660326; DOI=10.1038/nature11119;
RG Tomato Genome Consortium;
RT "The tomato genome sequence provides insights into fleshy fruit
RT evolution.";
RL Nature 485:635-641(2012).
RN [2] {ECO:0000313|EnsemblPlants:Solyc01g096900.3.1}
RP IDENTIFICATION.
RC STRAIN=cv. Heinz 1706 {ECO:0000313|EnsemblPlants:Solyc01g096900.3.1};
RG EnsemblPlants;
RL Submitted (JAN-2019) to UniProtKB.
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC family. {ECO:0000256|ARBA:ARBA00008263}.
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DR RefSeq; XP_004230064.1; XM_004230016.3.
DR AlphaFoldDB; A0A3Q7EN27; -.
DR STRING; 4081.A0A3Q7EN27; -.
DR PaxDb; 4081-Solyc01g096900-2-1; -.
DR EnsemblPlants; Solyc01g096900.3.1; Solyc01g096900.3.1; Solyc01g096900.3.
DR GeneID; 101251225; -.
DR Gramene; Solyc01g096900.3.1; Solyc01g096900.3.1; Solyc01g096900.3.
DR KEGG; sly:101251225; -.
DR InParanoid; A0A3Q7EN27; -.
DR OMA; THHWLLF; -.
DR OrthoDB; 1043at2759; -.
DR Proteomes; UP000004994; Chromosome 1.
DR GO; GO:0005694; C:chromosome; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0009330; C:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IBA:GO_Central.
DR CDD; cd00187; TOP4c; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR HAMAP; MF_01897; GyrA; 1.
DR InterPro; IPR005743; GyrA.
DR InterPro; IPR006691; GyrA/parC_rep.
DR InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR NCBIfam; TIGR01063; gyrA; 1.
DR PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR Pfam; PF03989; DNA_gyraseA_C; 6.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000004994};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 107..563
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
FT REGION 67..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..102
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 953 AA; 105288 MW; B43E8F0F6356DA83 CRC64;
MKLHTLNPQT SFVQSNSMAF STGIRLLRCY HHQFTFTAIP SRFSGLRKAS SELRFLSSVT
PSRKHVRPVS ARRKVTEEEV GEEGNGSVVL RDRDGNEGGG GERIVHTELH KEATEAYMSY
AMSVLLGRAL PDVRDGLKPV HRRILYAMHE LGLSSKKPYK KSARVVGEVL GKFHPHGDNA
VYDSLVRMAQ DFSLRSPLIR GHGNFGSIDA DPPAAMRYTE CRLEALTEAM LLADLEQNTV
DFVPNFDNSQ KEPSLLPARI PNLLLNGASG IAVGMATNIP PHNLGELVDA LSALIHNPEA
TLQELLEYMP GPDFPTGGII MGNIGILEAY RTGRGRVVIR GKTDIELLDA KTKRAAIIIQ
EIPYQTNKAS LVEKIADLVE NKTLEGVSDI RDESDRSGMR VVIELKRGSD PAIVLNNLYR
LTPLQSSFSC NMVGILNGQP KLMGLKELLQ AFLDFRCSVV ERRAKYKLSQ AQERNHIVEG
IIIGLDNLDE VINTIRKASS HALATANLRK EFELTEKQAE AILDISLRRL TALERNKFVD
EGKSLRTQIS KLEELLSSEK QILQLIEEEA LEIKDKYFTP RRSQLEDTDS GDLEDIDVIP
NEEMLLAISE KGYVKRMKPD TFNLQNRGTI GKSVGKLRVN DAMSDFLVCR AHDKVLYFSD
KGTVYSSPAY KIPECSRTAA GTPLIQILSL SDGERITSII PVSDFAGDQY LVMLTVNGYI
KKVSLNYFAS IRSTGIIAIQ LVPGDELKWV KCCSNNDFVA MASLNGMVIL TPCANIRALG
RNTRGSVAMR LKDGDKVASM DIIPDALQKE LDVTLAVHQR NKRSMNGPWL LFVSESGYGK
RVPVSRFRTS PLNRVGLIGY KFSSEDRLAA VFVVGFSFGE DGESDEQVVL VSQSGTVNRI
KVRDISIQSR YARGVILMRL EHAGKIQSAS LISAADADSD SDPEVEDGAA VEA
//
