ID A0A3Q7EQ66_SOLLC Unreviewed; 1635 AA.
AC A0A3Q7EQ66;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=UDP-glucose:glycoprotein glucosyltransferase {ECO:0008006|Google:ProtNLM};
OS Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC Solanum subgen. Lycopersicon.
OX NCBI_TaxID=4081 {ECO:0000313|EnsemblPlants:Solyc01g104040.3.1};
RN [1] {ECO:0000313|EnsemblPlants:Solyc01g104040.3.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Heinz 1706 {ECO:0000313|EnsemblPlants:Solyc01g104040.3.1};
RX PubMed=22660326; DOI=10.1038/nature11119;
RG Tomato Genome Consortium;
RT "The tomato genome sequence provides insights into fleshy fruit
RT evolution.";
RL Nature 485:635-641(2012).
RN [2] {ECO:0000313|EnsemblPlants:Solyc01g104040.3.1}
RP IDENTIFICATION.
RC STRAIN=cv. Heinz 1706 {ECO:0000313|EnsemblPlants:Solyc01g104040.3.1};
RG EnsemblPlants;
RL Submitted (JAN-2019) to UniProtKB.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen
CC {ECO:0000256|ARBA:ARBA00004319}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 8 family.
CC {ECO:0000256|ARBA:ARBA00006351}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 4081.A0A3Q7EQ66; -.
DR PaxDb; 4081-Solyc01g104040-2-1; -.
DR EnsemblPlants; Solyc01g104040.3.1; Solyc01g104040.3.1; Solyc01g104040.3.
DR Gramene; Solyc01g104040.3.1; Solyc01g104040.3.1; Solyc01g104040.3.
DR InParanoid; A0A3Q7EQ66; -.
DR OMA; KNFYRYV; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000004994; Chromosome 1.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003980; F:UDP-glucose:glycoprotein glucosyltransferase activity; IBA:GO_Central.
DR GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR GO; GO:0071712; P:ER-associated misfolded protein catabolic process; IBA:GO_Central.
DR GO; GO:0018279; P:protein N-linked glycosylation via asparagine; IBA:GO_Central.
DR CDD; cd06432; GT8_HUGT1_C_like; 1.
DR InterPro; IPR040497; Glyco_transf_24.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR009448; UDP-g_GGtrans.
DR InterPro; IPR040693; UGGT_TRXL_1.
DR InterPro; IPR040694; UGGT_TRXL_2.
DR InterPro; IPR040692; UGGT_TRXL_3.
DR InterPro; IPR040525; UGGT_TRXL_4.
DR PANTHER; PTHR11226; UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE; 1.
DR PANTHER; PTHR11226:SF0; UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE; 1.
DR Pfam; PF18404; Glyco_transf_24; 1.
DR Pfam; PF18400; Thioredoxin_12; 1.
DR Pfam; PF18401; Thioredoxin_13; 1.
DR Pfam; PF18402; Thioredoxin_14; 1.
DR Pfam; PF18403; Thioredoxin_15; 1.
DR Pfam; PF06427; UDP-g_GGTase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000004994};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 60..285
FT /note="UGGT thioredoxin-like"
FT /evidence="ECO:0000259|Pfam:PF18400"
FT DOMAIN 372..493
FT /note="UGGT thioredoxin-like"
FT /evidence="ECO:0000259|Pfam:PF18401"
FT DOMAIN 500..766
FT /note="UGGT thioredoxin-like"
FT /evidence="ECO:0000259|Pfam:PF18402"
FT DOMAIN 786..1027
FT /note="UDP-glucose:glycoprotein glucosyltransferase
FT thioredoxin-like"
FT /evidence="ECO:0000259|Pfam:PF18403"
FT DOMAIN 1347..1595
FT /note="Glucosyltransferase 24 catalytic"
FT /evidence="ECO:0000259|Pfam:PF18404"
FT REGION 148..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1602..1635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1635 AA; 185107 MW; 833FFEAD49D4F0DD CRC64;
MNRKHHSIHQ NSRMGTRFRF GFWVVIAVAF SICLSGYSVS AANSKPKNVQ VALRAKWSGT
PILLEAGELL SKESKDHFWD FIELWLHSAD ENSDCRSAKD CLKRIIKYGR SLLSESLIAM
FEFSLTLRSA SPRIVLYRQL AEESLSSFPL TDDNSSSSPD EGVLQQSDNA KNKKVNPLLV
GENPRSPEGN CCWVDTGERL FFDVAELLVW LQNAKEVSLD TLHPEIFEFD HVHPDSNVGN
PVAILYGALG THCFEQFHHT LTSAAREGKI YYVVRPVLPS GCESKSTPCG ALGTRDSLNL
GGYGVELALK NMEYKAMDDS IVKKGVTLED PHTEDLSQEV RGFIFSRILE RKQELTSEIM
AFRDYLLSST VSDTLDVWEL KDLGHQTAQR IVHAADPLQS MQEINQNFPS VVSSLSRMKL
NESIKEEIVT NQRMIPPGKS LMALNGALVN FEDIDLYLLV DMVHQELSLA DQYSKMKIPV
STVRKLLSAL PPSESSTFRV DYRSNHVHYL NNLEVDEMYK RWRSNLNEIL MPVYPGQMRY
IRKNIFHAVY VLDPSSICGL ETIDAIVSMF ENHIPIRFGV ILYSAKLIEE IESSGGQLPL
SYKEDSPNQE ELSSLIIRLF IYIKENRGIA TAFQFLSNVN KLRIESAAED PPEVHHVEGA
FVETLLPQAK TPPQDTLQKL EKDHTFKELS EESSLFVFKL GLAKRQCCLL FNGLVHEPTE
DALMNAMNDE LPKIQEHVYF GHINSHTDIL DKFLSESGVQ RYNPLIIAEG KVKPRFVSLS
ALILADNSFF NEINYLHSTE TIDDLKPVTH LLAVNIASEK GMRFLREGIH YLMTGTTTGR
LGVLFNSIQD PHSPSIFFMK VFQITASSYS HKKGALQFLD QICLLYQHEY MHASSAGTGN
SEAFMDKVFE LANSNGLSSM GLKSALSGLS DEKLKMHLKK VGKFLFGEVG LEYGANAVIT
NGRVISLADN TTFLSHDLQL LESLEFKQRI KHIVEIIEEV EWENIDPDTL TSKFISDIVM
SVSSSISMRD RNSEGARFEL LSAKYSAVVL ENENSSIHID AVIDPLSSSG QKLSSLLRLV
SKSVRPSMRL VLNPMSSLVD LPLKNYYRYV IPTLDDFSST DYTIYGPKAF FANMPPSKTL
TMNLDVPEPW LVEPVVAVHD LDNMLLENLG ETRTLQAVYE LEALVLTGHC SEKDQEPPRG
LQLILGTKST PHLVDTLVMA NLGYWQMKAF PGVWYLQLAP GRSSELYALK DDGDGGQETT
LSKRIIIDDL RGKLVHMEVI KKKGKEHEKL LVSADEDSHS QEKKKGNQNS WNSNILKWAS
GFIGGSDQSK KSKNTPVVTG GRHGKTINIF SVASGHLYER FLKIMILSVL KNTQRPVKFW
FIKNYLSPQF KDVIPHMARE YGFEYELITY KWPTWLHKQK EKQRIIWAYK ILFLDVIFPL
ALEKVIFVDA DQIVRTDMGE LYDMDLKGRP LAYTPFCDNN REMDGYRFWK QGFWKEHLRG
RPYHISALYV VDLLKFRETA AGDNLRDLPN YAQHTVPIFS LPQEWLWCES WCGNATKPKA
KTIDLCNNPM TKEPKLQGAK RIVAEWPELD YEARRVTAKI LGEDFDPQDQ AAPPAETQKT
ISDTPLEDEE SKSEL
//
