ID A0A3Q7EW77_SOLLC Unreviewed; 988 AA.
AC A0A3Q7EW77;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Cation-chloride cotransporter 1 {ECO:0008006|Google:ProtNLM};
GN Name=101263066 {ECO:0000313|EnsemblPlants:Solyc02g021620.3.1};
OS Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC Solanum subgen. Lycopersicon.
OX NCBI_TaxID=4081 {ECO:0000313|EnsemblPlants:Solyc02g021620.3.1};
RN [1] {ECO:0000313|EnsemblPlants:Solyc02g021620.3.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Heinz 1706 {ECO:0000313|EnsemblPlants:Solyc02g021620.3.1};
RX PubMed=22660326; DOI=10.1038/nature11119;
RG Tomato Genome Consortium;
RT "The tomato genome sequence provides insights into fleshy fruit
RT evolution.";
RL Nature 485:635-641(2012).
RN [2] {ECO:0000313|EnsemblPlants:Solyc02g021620.3.1}
RP IDENTIFICATION.
RC STRAIN=cv. Heinz 1706 {ECO:0000313|EnsemblPlants:Solyc02g021620.3.1};
RG EnsemblPlants;
RL Submitted (JAN-2019) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_004231552.1; XM_004231504.3.
DR AlphaFoldDB; A0A3Q7EW77; -.
DR STRING; 4081.A0A3Q7EW77; -.
DR PaxDb; 4081-Solyc02g021620-2-1; -.
DR EnsemblPlants; Solyc02g021620.3.1; Solyc02g021620.3.1; Solyc02g021620.3.
DR GeneID; 101263066; -.
DR Gramene; Solyc02g021620.3.1; Solyc02g021620.3.1; Solyc02g021620.3.
DR KEGG; sly:101263066; -.
DR InParanoid; A0A3Q7EW77; -.
DR OMA; KNWRPHI; -.
DR OrthoDB; 5490251at2759; -.
DR Proteomes; UP000004994; Chromosome 2.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF100; CATION-CHLORIDE COTRANSPORTER 1; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF03522; SLC12; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000004994};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 148..169
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 225..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..332
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 372..394
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 406..428
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 448..469
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 504..525
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 531..550
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 571..600
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 151..619
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 660..781
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 792..987
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..66
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..93
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 988 AA; 107983 MW; DC924C5E53F6E2EC CRC64;
MHSNRDKEEM DSGGEIEGVG DENEFPSSAV RGRKYSPVVA HDSDRAVLEM SSIDPRSSSS
PYSKQDLKKG KVNMQPDVAS EGSMPNHSVN GPQRESKLEL FGFDSLVNIL GLKSMTGDQI
QAPPSPRDGG DVSIALERPR PTAVKSGTLM GVFVPCLQNI MGIIYYIRFS WIVGMAGIGE
SLLLVAFCGS CTFLTTISLS AIATNGAMKG GGPYYLIGRA LGPEVGVSIG LCFFLGNAVA
GAMYVLGAVE TFLDAVPAAG ILRETVTRVN GTDIAPITRP SLHDLQIYGI VVTILLCFIV
FGGVKIINRV APAFLVPVVF SLVCIFSGIL LARNGRPAAG ITGLSSGSFK DNWGPAYQRT
SNAGIPDPNG KIYWSFNALV GLFFPAVTGI MAGSNRSASL KDTQRSIPIG TLAATLTTSA
LYLVSVLFFG SVATRDKLLT DRLLTASIAW PFPAIVYVGI ILSTLGAALQ SLTGAPRLLA
AIANDDILPV LNYFKVVDGG EPHVATFFTA FICIGCVVIG NLDLISPTIT MFYLLCYAGV
NLSCFLLDLL DAPSWRPRWK FHHWSLSLVG ALLCIVIMFL ISWTFTVVSL ALASLIYYYV
SIKGKAGDWG DGFKSAYFQL ALRSLRSLGA SQVHPKNWYP IPLIFCRPWG KLPENVPCHP
KLADFANCMK KKGRGMSIFI SIIDGDYHER VEDAKAACKQ LSTYIDYKQC EGVAEIVVAP
NMSEGFRGIV QTMGLGNLKP NIIVMRYPEI WRRENLIEIP ATFVGIINDC IVANKAVVIV
KGLDEWPNEY QRQYGTIDLY WIVRDGGLML LLSQLLLTKD SFEGCKIQVF CIAEEDSDAE
GLKADVKKFL YDLRMQAEVI VISMKSWEGQ GEQQESIEAF SAAQGRIASY LGEMKERAER
DKTPLMADGK PVVVNEQQVE KFLYTTLKLN STILKYSRMA AVVFVSLPPP PANHPAFFYM
EYMDLLVENV PRLLIVRGYR RDVVTLFT
//
