ID A0A3Q7FXJ4_SOLLC Unreviewed; 1193 AA.
AC A0A3Q7FXJ4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=NB-ARC domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC Solanum subgen. Lycopersicon.
OX NCBI_TaxID=4081 {ECO:0000313|EnsemblPlants:Solyc04g007490.3.1};
RN [1] {ECO:0000313|EnsemblPlants:Solyc04g007490.3.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Heinz 1706 {ECO:0000313|EnsemblPlants:Solyc04g007490.3.1};
RX PubMed=22660326; DOI=10.1038/nature11119;
RG Tomato Genome Consortium;
RT "The tomato genome sequence provides insights into fleshy fruit
RT evolution.";
RL Nature 485:635-641(2012).
RN [2] {ECO:0000313|EnsemblPlants:Solyc04g007490.3.1}
RP IDENTIFICATION.
RC STRAIN=cv. Heinz 1706 {ECO:0000313|EnsemblPlants:Solyc04g007490.3.1};
RG EnsemblPlants;
RL Submitted (JAN-2019) to UniProtKB.
CC -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC races carrying the avirulence gene Avr1. Resistance proteins guard the
CC plant against pathogens that contain an appropriate avirulence protein
CC via an indirect interaction with this avirulence protein. That triggers
CC a defense system including the hypersensitive response, which restricts
CC the pathogen growth. {ECO:0000256|ARBA:ARBA00002074}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR RefSeq; XP_004236955.1; XM_004236907.3.
DR RefSeq; XP_010319407.1; XM_010321105.2.
DR RefSeq; XP_010319408.1; XM_010321106.2.
DR RefSeq; XP_010319409.1; XM_010321107.2.
DR RefSeq; XP_010319410.1; XM_010321108.2.
DR RefSeq; XP_019068794.1; XM_019213249.1.
DR AlphaFoldDB; A0A3Q7FXJ4; -.
DR STRING; 4081.A0A3Q7FXJ4; -.
DR PaxDb; 4081-Solyc04g007490-2-1; -.
DR EnsemblPlants; Solyc04g007490.3.1; Solyc04g007490.3.1; Solyc04g007490.3.
DR Gramene; Solyc04g007490.3.1; Solyc04g007490.3.1; Solyc04g007490.3.
DR InParanoid; A0A3Q7FXJ4; -.
DR OMA; TEICHKI; -.
DR Proteomes; UP000004994; Chromosome 4.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0098542; P:defense response to other organism; IBA:GO_Central.
DR GO; GO:0009626; P:plant-type hypersensitive response; IEA:UniProtKB-KW.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR021929; R1A-like_N.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1235; DISEASE RESISTANCE RPP13-LIKE PROTEIN 1; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF12061; NB-LRR; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hypersensitive response {ECO:0000256|ARBA:ARBA00022667};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000004994}.
FT DOMAIN 118..343
FT /note="Late blight resistance protein R1A-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12061"
FT DOMAIN 362..436
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 488..708
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
SQ SEQUENCE 1193 AA; 137847 MW; 432E7B27B53110AA CRC64;
MLDEGDPDPD PVSILQTIEN EHEDLTDDKR KEIKLIKTEL WFLGRFLLGH WECSKSLQVR
IRSLLVFAED LYRSNFDADP SYVLRSIEHF NYFIPINYWE SEESLVPVTT PLNHVHMLAY
IDNVVQNFKD LLIVRLVKLP DVQSQVESVV KELRALKKFI FFLGEICIST EQIKCWQTFW
LHVRLVTTRA AILLYLPCYD RFSHMMQDNL MCSQIVCDDE LLKYILKLLS FGSTHVKLYL
NKAADEFMDF LLHVHMQLGA DSWTSDQNYT FTEQINCLRA LLKELPLIND IQDEMRIHFF
KRLVTLVIHA GLTVYSGGDW DQKMLLLYGM IRSVKTEICH KIREWVTSHL PKNDKLGFSN
CLLASLKEFL SGHSASLASV KDQIEVVHEE LKFFEPFIMR LAEQANNKHN ELQNLVGRVI
DKAYEVEYIL DSFAISDVPL TFLRMWLLEI IREIELIKTE LTKPKEKNMT SASHATDGEL
VGFTDVCKTI RDQLVGGSQE LDVVSIVGMA GSGKTTLARS FINDDIVVSH FDFFAECRVS
QEYTREDLLF SILSSANSGL TDISKRGADI LADRLRKTLL PKRYLLIIDD VWAVQAWDDL
RLCFPEAKKG SRIILTTRLK EVATYAKCVT EPINLRSMKD SESWLLLQKK VFGEEMCPEE
LKEVGQNIAF KCNGLPLSIV LVAGLLAKID KTERCWTRME LSFGERVQDG AKDLVKLSYE
DLPNKLKSCF LYFGAFLEDR EISVSKLTSL WIAEEFIKNN EDKCLEDTAE DYLSDLIGRN
LIMVSKRRST GKIKACRVHD LMLDFCKEKA KEDNFLLWLK RDRDSNPPRF YSERPMHRRL
SFYSNRDDLS EWRPSCSHAR SILFRELSDN ACSSMRHASF IFGNFKFLRV LDLEVVDVDS
FPTELNQLRY LAVQTTKNSI PSSIENLWNL QTFIVKRNGG QVWLPDTFWK LSKLRYVSIS
DGALFASRGA QESCGGNFLK LDNLETFSSI YVSRVNNMER MVRRTPNLRK LRCVFTDLGR
WGKNENRFPV LDSLSQLETL KVVFVGISEV GPSRLNFPEN LKKLTLCKFP LPPEEISTIA
KLVNLEVLKL RQVAFEMGEW EVRDQEFSQL KLLELENLKL SKWEVSEESF DRLEKLVLHG
CLHLKAIPDG FQDLNCLRYI EVKSCSEDVA DSARIIKETR EDNGQKCDVK IFS
//