ID A0A3Q7G9N0_SOLLC Unreviewed; 730 AA.
AC A0A3Q7G9N0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=CSC1/OSCA1-like 7TM region domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC Solanum subgen. Lycopersicon.
OX NCBI_TaxID=4081 {ECO:0000313|EnsemblPlants:Solyc04g077400.3.1};
RN [1] {ECO:0000313|EnsemblPlants:Solyc04g077400.3.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Heinz 1706 {ECO:0000313|EnsemblPlants:Solyc04g077400.3.1};
RX PubMed=22660326; DOI=10.1038/nature11119;
RG Tomato Genome Consortium;
RT "The tomato genome sequence provides insights into fleshy fruit
RT evolution.";
RL Nature 485:635-641(2012).
RN [2] {ECO:0000313|EnsemblPlants:Solyc04g077400.3.1}
RP IDENTIFICATION.
RC STRAIN=cv. Heinz 1706 {ECO:0000313|EnsemblPlants:Solyc04g077400.3.1};
RG EnsemblPlants;
RL Submitted (JAN-2019) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR RefSeq; XP_019069215.1; XM_019213670.1.
DR AlphaFoldDB; A0A3Q7G9N0; -.
DR STRING; 4081.A0A3Q7G9N0; -.
DR PaxDb; 4081-Solyc04g077400-2-1; -.
DR EnsemblPlants; Solyc04g077400.3.1; Solyc04g077400.3.1; Solyc04g077400.3.
DR GeneID; 101248383; -.
DR Gramene; Solyc04g077400.3.1; Solyc04g077400.3.1; Solyc04g077400.3.
DR InParanoid; A0A3Q7G9N0; -.
DR OMA; LWTHCLA; -.
DR OrthoDB; 1753647at2759; -.
DR Proteomes; UP000004994; Chromosome 4.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IBA:GO_Central.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF116; CSC1-LIKE PROTEIN RXW8; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 2.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000004994};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 98..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 154..175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 362..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 414..434
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 454..473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 485..503
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 515..532
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 552..584
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 605..626
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 632..651
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 5..175
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 198..258
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 302..349
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 360..625
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
SQ SEQUENCE 730 AA; 82648 MW; A2D7EF43F0BF46C4 CRC64;
MKLAALLTSA GINTAVSVVL FSLYSVLRKQ PSFVNVYFGA KIAQVRSRQQ DAFRFDRFVP
SPSWILKAWE TSDEEICATG GLDAVVFVRM IVFSKLTLLL LIVDSFRIFS IAAIVCNFLV
LPLNYFGKEM QRHQIPAETL EVFTIANVEE GSRWLWAHCL ALYLVSCCAC FLLYLEYKSI
SRMRLAYFTS SMSNPSYFTV LVRAIPWSRE ESYSGTVARF FTNYYASSFL SHQIVYRSGS
VQKLVTDAGK VCKMLKLAPR ELHIGSNSMR CGLCGTSTPF SMLPMDADDD QGRSDFGGSD
LSKKESAAAL VFFRTRYAAL VASQSLQSRN PMSWVTNLSP EPGDMYWSNI CVPYRLLWIR
KVAILVASMA LVAFFIVPVS LTQGLVHLDK LQKTFPFLRG VLKRKAMSQL ATGYLPSVVL
IIFMYMVPPI MLLFSTLEGS TSRSGRKRSA SIKVLCFFIW NVFFGNILSG SVIERFSKIF
KDVNYLLATA VPSTATFFMT YVLTSGWASL SCELMQPFGL LCNLFYMFIL RNKDVTTYGT
LTFPYHTEVP RILLFGLFGF VYSTLSPLIL PFLLVYFSLA YLVYRNQILN VYVTKYQTGG
TYWPIVHNAT IFSMVLMQVI AMAVFGLKKS TVASSFVIPL IIMTLLFNEY CRQRFQPLFM
QIPAQILIEM DRQDEQNGKM KEIHQKLTTS YTQFKSKSRT LGDPMPPNNN CRLEDLEINP
GKIPVHHLSS
//
