ID   A0A3Q7GD00_SOLLC        Unreviewed;      1146 AA.
AC   A0A3Q7GD00;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=NB-ARC domain-containing protein {ECO:0000259|Pfam:PF00931};
OS   Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC   Solanum subgen. Lycopersicon.
OX   NCBI_TaxID=4081 {ECO:0000313|EnsemblPlants:Solyc05g005130.2.1};
RN   [1] {ECO:0000313|EnsemblPlants:Solyc05g005130.2.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Heinz 1706 {ECO:0000313|EnsemblPlants:Solyc05g005130.2.1};
RX   PubMed=22660326; DOI=10.1038/nature11119;
RG   Tomato Genome Consortium;
RT   "The tomato genome sequence provides insights into fleshy fruit
RT   evolution.";
RL   Nature 485:635-641(2012).
RN   [2] {ECO:0000313|EnsemblPlants:Solyc05g005130.2.1}
RP   IDENTIFICATION.
RC   STRAIN=cv. Heinz 1706 {ECO:0000313|EnsemblPlants:Solyc05g005130.2.1};
RG   EnsemblPlants;
RL   Submitted (JAN-2019) to UniProtKB.
CC   -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC       races carrying the avirulence gene Avr1. Resistance proteins guard the
CC       plant against pathogens that contain an appropriate avirulence protein
CC       via an indirect interaction with this avirulence protein. That triggers
CC       a defense system including the hypersensitive response, which restricts
CC       the pathogen growth. {ECO:0000256|ARBA:ARBA00002074}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC       Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC   -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC       {ECO:0000256|ARBA:ARBA00008894}.
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DR   AlphaFoldDB; A0A3Q7GD00; -.
DR   STRING; 4081.A0A3Q7GD00; -.
DR   PaxDb; 4081-Solyc05g005130-1-1; -.
DR   EnsemblPlants; Solyc05g005130.2.1; Solyc05g005130.2.1; Solyc05g005130.2.
DR   Gramene; Solyc05g005130.2.1; Solyc05g005130.2.1; Solyc05g005130.2.
DR   InParanoid; A0A3Q7GD00; -.
DR   OMA; FTVANEI; -.
DR   Proteomes; UP000004994; Chromosome 5.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0098542; P:defense response to other organism; IBA:GO_Central.
DR   CDD; cd14798; RX-CC_like; 1.
DR   Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038005; RX-like_CC.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR   PANTHER; PTHR23155:SF1235; DISEASE RESISTANCE RPP13-LIKE PROTEIN 1; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   PRINTS; PR00364; DISEASERSIST.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Hypersensitive response {ECO:0000256|ARBA:ARBA00022667};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004994}.
FT   DOMAIN          487..725
FT                   /note="NB-ARC"
FT                   /evidence="ECO:0000259|Pfam:PF00931"
SQ   SEQUENCE   1146 AA;  132322 MW;  1F7592128C7CD780 CRC64;
     MLKSSTIDSS DSPMMDLVLM GFHEYILDNL QLKNETSLTF TNTNEVKKFY YGLLLLVTYL
     FDPLVQCSGF GTIEIEAAGD SNRNRRVSLV LQYLTVALKL IEPEETLMDM LTKATLKAPI
     LDMVESAHEE LIFLRAFLMD VLRQQMKLNK YHHLLRNVEE TANKLAQLSR FRNERFMDEN
     STWEVCLILS DFLYDIKFIK VEIRKVCIQV LDASLMTLPD IKGLLNFLSN RLDTVLDCDA
     GSIAFLMNRS RVLKEKLMYL GHFLADVVQH YNMHQGLKDL MKHVLDTKYV CLLSVGDYKS
     AWYYMLSLSD MKQLLKFVET EVKTIIPKAP ESSSYSFPKT NGLGFLQFFL GNLEELLCSK
     LDSVIDWKDQ IGSVKEGILC LRDHFAENFD ELDEVYGFIL KVTEMAYKAE FVIDSCLVSS
     HPLWYKSHRM SEVLKNIKLL NKAVTETYER KEIDVIVNKV AKTSMNPVAS LLAYTPRENE
     EMEGFHEAMD KIKRQLLRRS SQLDIISIVG MPGIGKTFLA EKIYNNLIVT PHFDVHAKCR
     VTQLYSWKEL LLTILNDVLD PADRTGKEDG ELATELRQVL LTKRFLILVD DVWDKTVWDH
     LYMCFRDAKN GSRIILTTRL SDIANYAKCK SEPHHLRLFR DDESWTLLQE EVFQGESCPT
     ELVDVGFRIA KSCGGLPLSI VLVGGVLKEK EKKEDLWKEV EESLGSKNIG SLQKSMSLIG
     FSYKNLPHHL KPCFLYFGGF FKGKDIHVSK LTRLWQAEGF VQANKEKRTD TAHDFLEDLI
     SRNLVMVMKE RPNDKVKSCR IHDLLHNFCL EKSKQENFLN QMNRGEDMLP EKPQDYRLFI
     HSYQDEIDSW RPCGSNVRSL QFKVADPDSL LWPRDISFIF DSFKLVKVLD LESFNIGGTF
     PSEVESLIHL RYFAVQTYAN SIPSFIAKLR NLETFVVRGL GGEVIIPSSI LKMVKLRHLL
     VKNRASFSLQ GNMGESFSNS QLDYLETFST PRLSYGQDAE MILTKMPNLR KLNCIFLETF
     SYLEKLKGRC VRFPTLEFLS HLESLKLVSN CYPSKLPHVF NFPSKLRELT LSKFRLPWYE
     ISIVGELPNL EILRLLSRAF EGNEWEVNDS EFRVLKYLNL DNINISQWSL SNDAFPKLEH
     LVLTKP
//