ID A0A3Q7GSC1_SOLLC Unreviewed; 971 AA.
AC A0A3Q7GSC1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Insulin degrading enzyme {ECO:0008006|Google:ProtNLM};
GN Name=543773 {ECO:0000313|EnsemblPlants:Solyc04g015680.3.1};
OS Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC Solanum subgen. Lycopersicon.
OX NCBI_TaxID=4081 {ECO:0000313|EnsemblPlants:Solyc04g015680.3.1};
RN [1] {ECO:0000313|EnsemblPlants:Solyc04g015680.3.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Heinz 1706 {ECO:0000313|EnsemblPlants:Solyc04g015680.3.1};
RX PubMed=22660326; DOI=10.1038/nature11119;
RG Tomato Genome Consortium;
RT "The tomato genome sequence provides insights into fleshy fruit
RT evolution.";
RL Nature 485:635-641(2012).
RN [2] {ECO:0000313|EnsemblPlants:Solyc04g015680.3.1}
RP IDENTIFICATION.
RC STRAIN=cv. Heinz 1706 {ECO:0000313|EnsemblPlants:Solyc04g015680.3.1};
RG EnsemblPlants;
RL Submitted (JAN-2019) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR RefSeq; NP_001233926.2; NM_001246997.2.
DR AlphaFoldDB; A0A3Q7GSC1; -.
DR SMR; A0A3Q7GSC1; -.
DR STRING; 4081.A0A3Q7GSC1; -.
DR PaxDb; 4081-Solyc04g015680-2-1; -.
DR EnsemblPlants; Solyc04g015680.3.1; Solyc04g015680.3.1; Solyc04g015680.3.
DR GeneID; 543773; -.
DR Gramene; Solyc04g015680.3.1; Solyc04g015680.3.1; Solyc04g015680.3.
DR KEGG; sly:543773; -.
DR InParanoid; A0A3Q7GSC1; -.
DR OMA; INQVMEH; -.
DR OrthoDB; 129328at2759; -.
DR Proteomes; UP000004994; Chromosome 4.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IBA:GO_Central.
DR GO; GO:0043171; P:peptide catabolic process; IBA:GO_Central.
DR GO; GO:0051603; P:proteolysis involved in protein catabolic process; IBA:GO_Central.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR032632; Peptidase_M16_M.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR Pfam; PF16187; Peptidase_M16_M; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000004994};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 35..169
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 197..374
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 382..661
FT /note="Peptidase M16 middle/third"
FT /evidence="ECO:0000259|Pfam:PF16187"
FT DOMAIN 666..853
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
SQ SEQUENCE 971 AA; 112385 MW; 37A53EC0E9E6CB46 CRC64;
MAVGKKEENM AVEIVKPRID KRDYRRIVLQ NNLEILLISD PETDKCAASM NVCVGAFSDP
EGLEGLAHFL EHMLFYASEK YPVEDSYSKY ITENGGSTNA FTSSEDTNYY FEVNADGFEE
ALDRFAQFFI KPLMSADATT REIKAVDSEH QKNLLSDPWR MNQLQKHLSA ENHPYHKFST
GSWDTLEVRP KERGIDTRQE LLKFYSENYS ANLMHLVVYS KDSLDKVEQL VRGKFQDIRN
IDRNQIHFTG QPCIMEHLQI LVRAVPIKQG HKLKIIWPIT PGIHHYKEGP CRYLGHLIGH
EGEGSLFYVL KKLGWATSLS AGESDWTNEF SFFKVAIDLT DAGQDHFEDI MGLLFKYIHL
LQQAGASKWI FEELSAICET AFHYQDKIRP SDYVVNVAMN MQHYPPEDWL VASSLPSKFN
PSIIQSFLNE LNPDNVRIFW ESTKFEGNTS MTEPWYGTAY SIEKVGGDSI KQWMEHAPSE
ELHLPAPNVF IPTDLSLKPV FEKTKVPILL RKSPYSRLWY KPDTAFSSPK AYVMIDFSCP
YCGHSPEAEV LTEIFTRLLM DYLNEYAYNA QVAGLYYDIS KTNSGFQLTL FGYNDKLRVL
LEAVIEKVAK FEVKPDRFSV VKELVTKQYQ NFKFQQPYQQ VMYYCSLLLK DNIWPWNEEL
EVLPHLKVDD LVKFYPLLMA RSFMECYVAG NVEQAEAESM IQLIEDVFFK GPQSISKPLF
ASQHLTNRVV NLERGVNYVY AAEGLNPSDE NSALVHYIQV HQDDFMLNVK LQLFALIAKQ
PAFHQLRSVE QLGYITVLMQ RSDSGVHGVQ FIVQSTAKDP KYIDTRVELF MKMFESKLYE
MTSDEFKNNV NALIDMKLEK HKNLREESRF YWREISDGTL KFDRRDREIV ALKQLTQKEL
TDFFDEYIKV GVPRKKALSV RVYGSSHSSQ FQAHKNEQME PNAVQIEEIF SFRRSRPLYS
SFKGGFGHVR L
//