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Database: UniProt
Entry: A0A3Q7GSC1_SOLLC
LinkDB: A0A3Q7GSC1_SOLLC
Original site: A0A3Q7GSC1_SOLLC 
ID   A0A3Q7GSC1_SOLLC        Unreviewed;       971 AA.
AC   A0A3Q7GSC1;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=Insulin degrading enzyme {ECO:0008006|Google:ProtNLM};
GN   Name=543773 {ECO:0000313|EnsemblPlants:Solyc04g015680.3.1};
OS   Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC   Solanum subgen. Lycopersicon.
OX   NCBI_TaxID=4081 {ECO:0000313|EnsemblPlants:Solyc04g015680.3.1};
RN   [1] {ECO:0000313|EnsemblPlants:Solyc04g015680.3.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Heinz 1706 {ECO:0000313|EnsemblPlants:Solyc04g015680.3.1};
RX   PubMed=22660326; DOI=10.1038/nature11119;
RG   Tomato Genome Consortium;
RT   "The tomato genome sequence provides insights into fleshy fruit
RT   evolution.";
RL   Nature 485:635-641(2012).
RN   [2] {ECO:0000313|EnsemblPlants:Solyc04g015680.3.1}
RP   IDENTIFICATION.
RC   STRAIN=cv. Heinz 1706 {ECO:0000313|EnsemblPlants:Solyc04g015680.3.1};
RG   EnsemblPlants;
RL   Submitted (JAN-2019) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
CC       {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR   RefSeq; NP_001233926.2; NM_001246997.2.
DR   AlphaFoldDB; A0A3Q7GSC1; -.
DR   SMR; A0A3Q7GSC1; -.
DR   STRING; 4081.A0A3Q7GSC1; -.
DR   PaxDb; 4081-Solyc04g015680-2-1; -.
DR   EnsemblPlants; Solyc04g015680.3.1; Solyc04g015680.3.1; Solyc04g015680.3.
DR   GeneID; 543773; -.
DR   Gramene; Solyc04g015680.3.1; Solyc04g015680.3.1; Solyc04g015680.3.
DR   KEGG; sly:543773; -.
DR   InParanoid; A0A3Q7GSC1; -.
DR   OMA; INQVMEH; -.
DR   OrthoDB; 129328at2759; -.
DR   Proteomes; UP000004994; Chromosome 4.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IBA:GO_Central.
DR   GO; GO:0043171; P:peptide catabolic process; IBA:GO_Central.
DR   GO; GO:0051603; P:proteolysis involved in protein catabolic process; IBA:GO_Central.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR001431; Pept_M16_Zn_BS.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   InterPro; IPR032632; Peptidase_M16_M.
DR   PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR   PANTHER; PTHR43690; NARDILYSIN; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 2.
DR   Pfam; PF16187; Peptidase_M16_M; 1.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR   PROSITE; PS00143; INSULINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004994};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          35..169
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          197..374
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   DOMAIN          382..661
FT                   /note="Peptidase M16 middle/third"
FT                   /evidence="ECO:0000259|Pfam:PF16187"
FT   DOMAIN          666..853
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
SQ   SEQUENCE   971 AA;  112385 MW;  37A53EC0E9E6CB46 CRC64;
     MAVGKKEENM AVEIVKPRID KRDYRRIVLQ NNLEILLISD PETDKCAASM NVCVGAFSDP
     EGLEGLAHFL EHMLFYASEK YPVEDSYSKY ITENGGSTNA FTSSEDTNYY FEVNADGFEE
     ALDRFAQFFI KPLMSADATT REIKAVDSEH QKNLLSDPWR MNQLQKHLSA ENHPYHKFST
     GSWDTLEVRP KERGIDTRQE LLKFYSENYS ANLMHLVVYS KDSLDKVEQL VRGKFQDIRN
     IDRNQIHFTG QPCIMEHLQI LVRAVPIKQG HKLKIIWPIT PGIHHYKEGP CRYLGHLIGH
     EGEGSLFYVL KKLGWATSLS AGESDWTNEF SFFKVAIDLT DAGQDHFEDI MGLLFKYIHL
     LQQAGASKWI FEELSAICET AFHYQDKIRP SDYVVNVAMN MQHYPPEDWL VASSLPSKFN
     PSIIQSFLNE LNPDNVRIFW ESTKFEGNTS MTEPWYGTAY SIEKVGGDSI KQWMEHAPSE
     ELHLPAPNVF IPTDLSLKPV FEKTKVPILL RKSPYSRLWY KPDTAFSSPK AYVMIDFSCP
     YCGHSPEAEV LTEIFTRLLM DYLNEYAYNA QVAGLYYDIS KTNSGFQLTL FGYNDKLRVL
     LEAVIEKVAK FEVKPDRFSV VKELVTKQYQ NFKFQQPYQQ VMYYCSLLLK DNIWPWNEEL
     EVLPHLKVDD LVKFYPLLMA RSFMECYVAG NVEQAEAESM IQLIEDVFFK GPQSISKPLF
     ASQHLTNRVV NLERGVNYVY AAEGLNPSDE NSALVHYIQV HQDDFMLNVK LQLFALIAKQ
     PAFHQLRSVE QLGYITVLMQ RSDSGVHGVQ FIVQSTAKDP KYIDTRVELF MKMFESKLYE
     MTSDEFKNNV NALIDMKLEK HKNLREESRF YWREISDGTL KFDRRDREIV ALKQLTQKEL
     TDFFDEYIKV GVPRKKALSV RVYGSSHSSQ FQAHKNEQME PNAVQIEEIF SFRRSRPLYS
     SFKGGFGHVR L
//
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