ID A0A3Q7QW30_VULVU Unreviewed; 404 AA.
AC A0A3Q7QW30;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Corticosteroid-binding globulin {ECO:0000256|ARBA:ARBA00039186};
DE AltName: Full=Serpin A6 {ECO:0000256|ARBA:ARBA00043180};
DE AltName: Full=Transcortin {ECO:0000256|ARBA:ARBA00041777};
GN Name=LOC112907362 {ECO:0000313|RefSeq:XP_025838379.1,
GN ECO:0000313|RefSeq:XP_025838380.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025838379.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025838379.1, ECO:0000313|RefSeq:XP_025838380.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025838379.1,
RC ECO:0000313|RefSeq:XP_025838380.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025838379.1,
RC ECO:0000313|RefSeq:XP_025838380.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Major transport protein for glucocorticoids and progestins in
CC the blood of almost all vertebrate species.
CC {ECO:0000256|ARBA:ARBA00037222}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the serpin family.
CC {ECO:0000256|RuleBase:RU000411}.
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DR RefSeq; XP_025838379.1; XM_025982594.1.
DR RefSeq; XP_025838380.1; XM_025982595.1.
DR STRING; 9627.ENSVVUP00000025524; -.
DR Ensembl; ENSVVUT00000033806; ENSVVUP00000025524; ENSVVUG00000018718.
DR Ensembl; ENSVVUT00000033809; ENSVVUP00000025526; ENSVVUG00000018718.
DR KEGG; vvp:112907362; -.
DR OMA; HDSELPC; -.
DR OrthoDB; 3218836at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
DR GO; GO:0008211; P:glucocorticoid metabolic process; IEA:Ensembl.
DR CDD; cd19554; serpinA6_CBG; 1.
DR Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 1.
DR InterPro; IPR023795; Serpin_CS.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR000215; Serpin_fam.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR PANTHER; PTHR11461:SF34; CORTICOSTEROID-BINDING GLOBULIN; 1.
DR PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR Pfam; PF00079; Serpin; 1.
DR PRINTS; PR00780; LEUSERPINII.
DR SMART; SM00093; SERPIN; 1.
DR SUPFAM; SSF56574; Serpins; 1.
DR PROSITE; PS00284; SERPIN; 1.
PE 3: Inferred from homology;
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Steroid-binding {ECO:0000256|ARBA:ARBA00022665};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..404
FT /note="Corticosteroid-binding globulin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041077968"
FT DOMAIN 47..403
FT /note="Serpin"
FT /evidence="ECO:0000259|SMART:SM00093"
SQ SEQUENCE 404 AA; 45559 MW; 6B8A04CDD5A365C7 CRC64;
MLLALCTYFL WLSTSDLLTV QAKDPDTDVT KSSSHRDLAP KNVDFAFNLY RHLVASSPDK
NVFISPVSIS MALAMLSLGA CGYTRVQLLQ GLGFNLTKMS EAEIHQGFRH LRHLLEKSDT
MLEMTMGNAL FLDRSLELLE PFSADTKHYY DLEAWATDFQ DGTGASRQIN EYIKNKTQGK
IVDLLSKLDS SAMLILVNYI FFKGTWEHPF DPESTREEDF YVNETTMVRV PMMFQSSNIK
HLNDQVLPCQ LVQLEYMGNG TVFFILPEEG KMDTVIAALS RDTIQRWSES FTRSQVNLYI
PKVSLSGAYD LRAILRDMGI ADLLDNGADF SGMTREAQPK LSKVVHKAVL QLHEKGLEAA
GPAGVTPNVE SEPLTFHFNR PFIVMIFDHF TWSSLFLGKV VNPT
//
