ID A0A3Q7R0C5_VULVU Unreviewed; 1199 AA.
AC A0A3Q7R0C5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Neuronal cell adhesion molecule isoform X12 {ECO:0000313|RefSeq:XP_025839829.1};
GN Name=NRCAM {ECO:0000313|RefSeq:XP_025839829.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025839829.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025839829.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025839829.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025839829.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC L1/neurofascin/NgCAM family. {ECO:0000256|ARBA:ARBA00008588}.
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DR RefSeq; XP_025839829.1; XM_025984044.1.
DR AlphaFoldDB; A0A3Q7R0C5; -.
DR Ensembl; ENSVVUT00000031111; ENSVVUP00000023522; ENSVVUG00000017196.
DR OMA; RAHAPFF; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 4.
DR CDD; cd05868; Ig4_NrCAM; 1.
DR CDD; cd05874; IgI_NrCAM; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR026966; Neurofascin/L1/NrCAM_C.
DR PANTHER; PTHR44170:SF15; NEURONAL CELL ADHESION MOLECULE; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF13882; Bravo_FIGEY; 1.
DR Pfam; PF00041; fn3; 4.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 3.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 6.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 6.
DR PROSITE; PS00290; IG_MHC; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1064..1085
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 46..134
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 141..235
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 267..356
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 361..448
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 454..541
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 546..632
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 649..744
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 746..843
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 848..950
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 954..1051
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1094..1199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1094..1150
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1199 AA; 132576 MW; 8F432B224395BBFF CRC64;
MQLKIMPKKK RLSAGGAPLI LFLCQMISAL EVPLDPKLLE DLVQPPTITQ QSPKDYIIDP
RENIVIQCEA KGKPPPSFSW TRNGTHFDID KDPLVTMKPG SGTLTINIMS EGKAETYEGV
YQCTARNERG AAISNNIVVR PSRSPLWTKE KLEPITLRNG QSLILPCRPP LGLPPPIIFW
MDNSFQRLPQ SERVSQGLNG DLYFSNVLPE DTREDYICYA RFNHTQTIQQ KQPISVKVIS
VDELNDTIAA NLSDTEFYSA KSNRERPPTF LTPEGNASHK EELRGNVLSL ECIAEGLPTP
IIYWIKEDGT LPINRTFYRN FKKTLQIIQV SEADSGNYQC IAKNALGAIH HTITVTVKAA
PYWIMAPQNL VLSPGEDGTL ICRANGNPKP RISWLSNGVP IEIAPDDPSR KIDGDTIIFS
NVQERSSAVY QCNASNEYGY LLANAFVNVL AEPPRILTSA NTLYQVIADR PALLDCAFFG
SPLPTIEWFK GAKGSALHED IYVLHENGTL EIPVAQKDST GTYTCVARNK LGVAKNEVHL
EVKDATRIIK QPEYAVVQRG STVSFECKVK HDHTLIPTIT WLKDNGELPN DGRFTVDKDH
LVVADVRDND GGTYTCVANT TLDNVSASAV LSVVAPTPTP APIYDVPNPP FDLELTDQLD
KSVQLSWTPG DDNNSPITKF IIEYEDAMHE AGLWHHQTEV SGMQTTAQLK LSPYVNYSFR
VMAVNNLGRS LPSEASEQYL TKAAEPDTNP TAVEGLGSEP DNLVITWKPL NGFESNGPGL
QYKVSWRQKD GDDEWTSVVV ANVSKYIVSG TPTFVPYLIK VQALNDVGFA PEPAVVMGHS
GEDLPMVAPG NVRVNVVNST LAEVHWDPVP LKSIRGHLQG YRIYYWKAQG SSKRNRRHIE
KKILTFQGNK THGMLPGLEP YSHYTLNVRV VNGKGEGPAS PDRVFNTPEG VPSAPSSLKI
VNPTLDSLTL EWDPPSRPNG ILTEYTLKYQ PINSTHELGP LVDLKIPANK TRWTLKNLNF
STRYKFYFYA QTAAGSGSQI TEEAVTTVDE AMASRQVDIA TQGWFIGLMC AVALLILILL
IVCFIRRNKG GKYPVKEKED AHADPEIQPM KEDDGTFGEY SDAEDHKPLK KGSRTPSDRT
VKKEDSDDSL VDYGEGVNGQ FNEDGSFIGQ YSGKKEKEPA EGNESSEAPS PVNAMNSFV
//
