ID   A0A3Q7R147_VULVU        Unreviewed;       291 AA.
AC   A0A3Q7R147;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=Transmembrane emp24 domain-containing protein 1 {ECO:0000256|ARBA:ARBA00040024};
DE   AltName: Full=p24 family protein gamma-1 {ECO:0000256|ARBA:ARBA00041274};
GN   Name=TMED1 {ECO:0000313|RefSeq:XP_025839223.1};
OS   Vulpes vulpes (Red fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX   NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025839223.1};
RN   [1]
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (JAN-2019) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_025839223.1}
RP   IDENTIFICATION.
RC   STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025839223.1};
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_025839223.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC       Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC       Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004115}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004115}.
CC       Endoplasmic reticulum-Golgi intermediate compartment membrane
CC       {ECO:0000256|ARBA:ARBA00004151}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004151}. Golgi apparatus, cis-Golgi network
CC       membrane {ECO:0000256|ARBA:ARBA00004619}; Single-pass type I membrane
CC       protein {ECO:0000256|ARBA:ARBA00004619}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003827}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479,
CC       ECO:0000256|RuleBase:RU003827}.
CC   -!- SIMILARITY: Belongs to the EMP24/GP25L family.
CC       {ECO:0000256|ARBA:ARBA00007104, ECO:0000256|RuleBase:RU003827}.
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DR   RefSeq; XP_025839223.1; XM_025983438.1.
DR   AlphaFoldDB; A0A3Q7R147; -.
DR   Proteomes; UP000286640; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR015720; Emp24-like.
DR   InterPro; IPR009038; GOLD_dom.
DR   InterPro; IPR036598; GOLD_dom_sf.
DR   PANTHER; PTHR22811; TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR22811:SF40; TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF01105; EMP24_GP25L; 1.
DR   SMART; SM01190; EMP24_GP25L; 1.
DR   SUPFAM; SSF101576; Supernatant protein factor (SPF), C-terminal domain; 1.
DR   PROSITE; PS50866; GOLD; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW   Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003827};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|ARBA:ARBA00022927}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..291
FT                   /note="Transmembrane emp24 domain-containing protein 1"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018580534"
FT   DOMAIN          42..124
FT                   /note="GOLD"
FT                   /evidence="ECO:0000259|PROSITE:PS50866"
SQ   SEQUENCE   291 AA;  32317 MW;  3DC7BAD1BCF22AF0 CRC64;
     MAAGAALALA LWLLLPPMGV EGAGPPPIQD GEFTFLLPAG RKQCFYQSAP ANASLETEYQ
     VIGGAGLDVD FTLESPQGVL LVSESRKADG VHTVEPTEAG DYKLCFDNSF STISDKLVFF
     ELIFDSLQDD EEVEGWAEAV EPEEMLDVKM EDIKESIETM KTRLERSIQM LTLLRAFEAR
     DRNLQEGNLE RVNFWSAVNV AVLLLVAVLQ HCPEHHDGQT LGSHVGKGEG RLRNRSTWAW
     MPVELPLLPR MNTRLALNCW ERWAVGKVVL RQQGECRCLA VIKNHLALAD S
//