ID A0A3Q7R508_VULVU Unreviewed; 298 AA.
AC A0A3Q7R508;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Acetylserotonin O-methyltransferase {ECO:0000256|ARBA:ARBA00040730};
DE EC=2.1.1.4 {ECO:0000256|ARBA:ARBA00039116};
DE AltName: Full=Hydroxyindole O-methyltransferase {ECO:0000256|ARBA:ARBA00043054};
GN Name=ASMT {ECO:0000313|RefSeq:XP_025840412.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025840412.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025840412.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025840412.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025840412.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Catalyzes the transfer of a methyl group onto N-
CC acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine).
CC {ECO:0000256|ARBA:ARBA00037645}.
CC -!- PATHWAY: Aromatic compound metabolism; melatonin biosynthesis;
CC melatonin from serotonin: step 1/2. {ECO:0000256|ARBA:ARBA00037926}.
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DR RefSeq; XP_025840412.1; XM_025984627.1.
DR AlphaFoldDB; A0A3Q7R508; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR GO; GO:0030187; P:melatonin biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR031725; ASMT_dimerisation.
DR InterPro; IPR016461; COMT-like.
DR InterPro; IPR001077; O_MeTrfase_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11746:SF327; ACETYLSEROTONIN O-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR11746; O-METHYLTRANSFERASE; 1.
DR Pfam; PF16864; Dimerisation2; 1.
DR Pfam; PF00891; Methyltransf_2; 1.
DR PIRSF; PIRSF005739; O-mtase; 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51683; SAM_OMT_II; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Melatonin biosynthesis {ECO:0000256|ARBA:ARBA00043260};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT DOMAIN 12..100
FT /note="Acetylserotonin O-methyltransferase dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16864"
FT DOMAIN 186..280
FT /note="O-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00891"
FT ACT_SITE 208
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005739-1"
SQ SEQUENCE 298 AA; 32876 MW; 0D3C21A4ECEE6F6D CRC64;
MSSPEEQAFR LLTEYSNGFM VSQVLFAACE LGVFDLLAEA PEPLGAAAVA ARLGTSSHGT
ELLLDTCVSL KLLQVETKTG KALYQNTELS STYLVRASPK CQGNMLRYLA RTTYLCWGHL
TQAVRDGRNQ YLEAFGVPSD QLFSAIYRSE DERLLFMRGL QDVWSVSGRP VLGAFDLSPF
PLICDVGGDF FKDPLPEADL YLLARVLHDW TDERCSRLLA RIRRACKPGG GVLVIESLLA
ADGRGPLTAQ LYSLNMLVQT EGRERTPAQY RALLAAAGFR HVQCRRTGGL YDAILATR
//
