ID   A0A3Q7R5Q9_VULVU        Unreviewed;      1241 AA.
AC   A0A3Q7R5Q9;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=DENN domain-containing protein 3 {ECO:0000313|RefSeq:XP_025840853.1};
GN   Name=DENND3 {ECO:0000313|RefSeq:XP_025840853.1};
OS   Vulpes vulpes (Red fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX   NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025840853.1};
RN   [1]
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (JAN-2019) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_025840853.1}
RP   IDENTIFICATION.
RC   STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025840853.1};
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_025840853.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_025840853.1; XM_025985068.1.
DR   AlphaFoldDB; A0A3Q7R5Q9; -.
DR   STRING; 9627.ENSVVUP00000019795; -.
DR   KEGG; vvp:112909229; -.
DR   OrthoDB; 5354449at2759; -.
DR   Proteomes; UP000286640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.450.200; -; 1.
DR   Gene3D; 3.40.50.11500; -; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR001194; cDENN_dom.
DR   InterPro; IPR005112; dDENN_dom.
DR   InterPro; IPR043153; DENN_C.
DR   InterPro; IPR037516; Tripartite_DENN.
DR   InterPro; IPR005113; uDENN_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR12296:SF21; DENN DOMAIN-CONTAINING PROTEIN 3; 1.
DR   PANTHER; PTHR12296; DENN DOMAIN-CONTAINING PROTEIN 4; 1.
DR   Pfam; PF02141; DENN; 1.
DR   Pfam; PF03456; uDENN; 1.
DR   SMART; SM00801; dDENN; 1.
DR   SMART; SM00799; DENN; 1.
DR   SMART; SM00320; WD40; 3.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50211; DENN; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW   Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW   ProRule:PRU00221}.
FT   DOMAIN          46..471
FT                   /note="UDENN"
FT                   /evidence="ECO:0000259|PROSITE:PS50211"
FT   REPEAT          1027..1069
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REGION          49..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|RefSeq:XP_025840853.1"
SQ   SEQUENCE   1241 AA;  139004 MW;  6FC1BADC47559788 CRC64;
     CPFLLQAQRK GVGGPPLEPE VLSVFVPPFV TKEDSQTAGA PCATLSKTRR RSFRKKRDKP
     KSEPWKGLPP EDVTVPNGVD LLALPQLCFP GGLCVASEPK EDCVHFLVLT DVCGNRTYGV
     VAQYYRPLHY ESCFYNGKAH WEPSWPTAGV AGCFVPFAVC VVSKLPYYNA LKDCLSCLLT
     HLKLCKDFEV DNHIKDFAAK LSLIPSPPPG PLHLVFNMKP LQIVFPSRAD PESPVIDLDL
     HLPLLCFRPE KVLQILTCLL TEQRIVFFSS NWALLPLVAE CFMAYLHPLQ WQHTFVPVLS
     GQMLDFVMAP TSFLMGCHLD YFEEVSKEAD GLVLINIDNG TITCSNDEDV DLPDVPLLAA
     QTFIQRVQSL QLHHELDLAH LGASTDLNEG RARRRAWQRR LNCQVQQVAL QLLFSIFREV
     KNHLNYEHRV FNSEEFLKTR APGDQQFYRQ VLDTYMFHAF LKARLSRRMD AFAQMDLNTQ
     SEEDRLNGML ASPRRPTIEK MASRKSSALH AVHRRMVVSM PNLQDIAVPE LLARNSSLRK
     VDSTGCGSVV LNVTPPSTYT FKIPEIHFPL VSQCVQAYYS DCVALLSKAM GLLAPDSSVL
     LARYYYLRGA VHLMQGQLLD ALLDFQSLYK TDIRIFPADL VRRTVGSLSG PQRTQAERVP
     ELRRLISEVV DKPGEAPKPD DRVKNFELPK KHMQLDDFVK RVQESGIVKD TNTIHRLFEA
     LTVGHQKQID PETFKDFYNC WKEAEAEAQE VSLPLSVTEH LDKNECVYKL SSSVKTNRGV
     GKIAMTQKRL FLLTEGRPGY VEISTFRNIE EVRSTTVAFL LLRIPTLKIK VMSKKEVFEA
     NLKTECDLWH LMVKEMWAGK KLADDHKDPQ YIQQALTHVL LMDAVVGTLQ SPAAIYAASK
     LSHFDRMKNE MSTPVPRTTS ETLKHKINPS AGETCPHAVD VLLYTPGHLD PAEKVEDARP
     KLWCALDEGK VTVFDASSWT IHQQCFKVGA SKLNCMVMAE QNQVWVGSED SVIYIINIHS
     MSCNKQLTDH RSSVTDLVAQ NGTPSKVYSC SADGTVLAWN VSTLRVTSRF QLPGGGLSSI
     SLHDGCLWCC TGTSIVAMMT SGLLCQELKV GENFKEMSTS FVGFQLLPQQ EQLWVACAGL
     ASIYIWSLAD LTRPPHRVPL QDCSEVSCMI RVKQQIWVGG TGLSQGLARG KIYVIDAERK
     TVAKELVAHI DRVTTLCSAE DRYVLSGSGG GEGKIAIWKV E
//