ID A0A3Q7R686_VULVU Unreviewed; 1484 AA.
AC A0A3Q7R686;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X7 {ECO:0000313|RefSeq:XP_025840882.1};
GN Name=MAGI1 {ECO:0000313|RefSeq:XP_025840882.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025840882.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025840882.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025840882.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025840882.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
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DR RefSeq; XP_025840882.1; XM_025985097.1.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00992; PDZ_signaling; 5.
DR CDD; cd00201; WW; 2.
DR Gene3D; 2.20.70.10; -; 2.
DR Gene3D; 2.30.42.10; -; 6.
DR Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR10316; MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED; 1.
DR PANTHER; PTHR10316:SF12; MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF16663; MAGI_u1; 1.
DR Pfam; PF16666; MAGI_u5; 1.
DR Pfam; PF00595; PDZ; 5.
DR Pfam; PF00397; WW; 2.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 6.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 6.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 6.
DR PROSITE; PS01159; WW_DOMAIN_1; 2.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 4: Predicted;
KW Kinase {ECO:0000313|RefSeq:XP_025840882.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000313|RefSeq:XP_025840882.1}.
FT DOMAIN 17..104
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 95..188
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT DOMAIN 299..332
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 346..379
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 463..532
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 634..712
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 832..914
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 989..1084
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1142..1224
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 235..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 382..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 711..821
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 923..978
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1102..1135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1224..1484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..417
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 578..592
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 728..757
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 929..973
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1102..1124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1275..1450
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1484 AA; 162952 MW; 342730EF09F1A2F8 CRC64;
MSRVIQKKNH WTSKIHECTV RRGPQGELGV TVLGGAENGE FPYVGAVAEA PKGLPGGGEG
PRLGEGELLL EVQGIRVSGL PRYDVLGVID SCKEAVTFKA VRQGGKLNKD LRHFLNQRFQ
KGSPDHELQQ TIRDNLYRHA VPCTTRSPRE GEVPGVDYNF LTVKEFLDLE QSGTLLEVGT
YEGNYYGTPK PPSQPVSGKV ITTDALQSLQ SGSKQSTPKR TKSYNDMQNA GIVHAENEEE
DDVPEMNSSF TADSGDQEEH TLQEAALPPV NSSIVAAPIT DASQKFPQYL PLCAEDNLGP
LPENWEMAYT ENGEVYFIDH NTKTTSWLDP RCLNKQQKPL EECEDDELPA GWEKIEDPVY
GIYYVDHINR KTQYENPVLE AKRKKQLEQQ QQPQQQQQQQ QQQQQQQQQQ QPPEEWTEDH
SSLVPPVIPN HPPSNPEPAR EAPLQGKPFF TRNPSELKGK FIHTKLRKSS RGFGFTVVGG
DEPDEFLQIK SLVLDGPAAL DGKMETGDVI VSVNDTCVLG HTHAQVVKIF QSIPIGASVD
LELCRGYPLP FDPDDPNTSL VTSVAILDKE PIIVNGQETY DSPASHSSKT GKVNGMKDAR
PSSPADVASN GSHGYPNDTV SLASSIATQP ELITVHIVKG PMGFGFTIAD SPGGGGQRVK
QIVDSPRCRG LKEGDLIVEV NKKNVQALTH NQVVDMLIEC PKGSEVTLLV QRGGLPVPKK
SPKSQPLERK DSQNSSQHSV SSHRSLHTAS PSHSTQVLPE YPPAEAPAPD QTDSSGQKKP
DPFKIWAQSR SMYENRPMSP SPASGLSKGE REREINSTSF GECQIPDCQE QDIFLWRKET
GFGFRILGGN EPGEPIYIGH IVPLGAADTD GRLRSGDELI CVDGTPVIGK SHQLVVQLMQ
QAAKQGHVNL TVRRKVVFAA PKAENEVPSP ASSHHSSNQP ASLTEEKRTP QGSQNSLNTV
SSGSGSTSGI GSGGGGGSGV VSTAVQPYDV EIRRGENEGF GFVIVSSVSR PEAGTTFGNA
CVAMPHKIGR IIEGSPADRC GKLKVGDRIL AVNGCSITNK SHSDIVNLIK EAGNTVTLRI
IPGDESSNAT LLTNAEKIAT ITTTHTPSQQ GTQETRNTTK PKPESQFEFK APQAAQEQDF
YTVELERGAK GFGFSLRGGR EYNMDLYVLR LAEDGPAERC GKMRIGDEIL EINGETTKNM
KHSRAIELIK NGGRRVRLFL KRGDGSVPEY DPSSDRHGPA AAAGPQGVPE VRAAPPDRRP
HPSLESSYPP DLHQSSQHGE KRAHGRDPKG SSRESSRQPN EHHTWNGTSR RPDGGACRPK
DRAPEGRREA PPERLVPNGP KRRSPEKQRR EGTRSADTTL ERRERPERRR ERSPGRRRDG
SPGARRRSLE RLLEQTRPAE RRRGSSPERR AKSTERRRAR SPERRRERSL EKRDRDRDRD
REEQRGGARG RAEPGPKPAP SGCRPAAPEP RRRPYKECST DLSI
//
