ID A0A3Q7R6M9_VULVU Unreviewed; 219 AA.
AC A0A3Q7R6M9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Leukemia inhibitory factor {ECO:0000256|ARBA:ARBA00016836};
GN Name=LIF {ECO:0000313|RefSeq:XP_025841799.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025841799.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025841799.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025841799.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025841799.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: LIF has the capacity to induce terminal differentiation in
CC leukemic cells. Its activities include the induction of hematopoietic
CC differentiation in normal and myeloid leukemia cells, the induction of
CC neuronal cell differentiation, and the stimulation of acute-phase
CC protein synthesis in hepatocytes. {ECO:0000256|ARBA:ARBA00024822}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the LIF/OSM family.
CC {ECO:0000256|ARBA:ARBA00005971}.
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DR RefSeq; XP_025841799.1; XM_025986014.1.
DR AlphaFoldDB; A0A3Q7R6M9; -.
DR STRING; 9627.ENSVVUP00000004444; -.
DR KEGG; vvp:112909866; -.
DR OrthoDB; 5301125at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005146; F:leukemia inhibitory factor receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0010646; P:regulation of cell communication; IEA:UniProt.
DR GO; GO:0023051; P:regulation of signaling; IEA:UniProt.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR003624; Leukemia_IF.
DR InterPro; IPR001581; Leukemia_IF/oncostatin.
DR InterPro; IPR019827; Leukemia_IF/oncostatin_CS.
DR PANTHER; PTHR10633; LEUKEMIA INHIBITORY FACTOR; 1.
DR PANTHER; PTHR10633:SF0; LEUKEMIA INHIBITORY FACTOR; 1.
DR Pfam; PF01291; LIF_OSM; 1.
DR PRINTS; PR01883; LEUKAEMIAIF.
DR SMART; SM00080; LIF_OSM; 1.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
DR PROSITE; PS00590; LIF_OSM; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
SQ SEQUENCE 219 AA; 24025 MW; 3A3439DA631C78FF CRC64;
MKARSSQGKT ELEVELGHWC PWGGVVPLLL VLHWKHGAGS PLPITPVNAT CATRHPCHSN
LMNQIRNQLA QLNGSANALF ILYYTAQGEP FPNNLDKLCG PNVTDFPPFH ANSTEKTRLV
ELYRIIAYLG ASLGNITRDQ KVLNPNALSL HSKLNATADI MRGLLSNVLC RLCSKYHVAH
VDVAYGPDTS GKDVFQKKKL GCQLLGKYKQ VIAVVAQAF
//