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Database: UniProt
Entry: A0A3Q7R6M9_VULVU
LinkDB: A0A3Q7R6M9_VULVU
Original site: A0A3Q7R6M9_VULVU 
ID   A0A3Q7R6M9_VULVU        Unreviewed;       219 AA.
AC   A0A3Q7R6M9;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=Leukemia inhibitory factor {ECO:0000256|ARBA:ARBA00016836};
GN   Name=LIF {ECO:0000313|RefSeq:XP_025841799.1};
OS   Vulpes vulpes (Red fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX   NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025841799.1};
RN   [1]
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (JAN-2019) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_025841799.1}
RP   IDENTIFICATION.
RC   STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025841799.1};
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_025841799.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: LIF has the capacity to induce terminal differentiation in
CC       leukemic cells. Its activities include the induction of hematopoietic
CC       differentiation in normal and myeloid leukemia cells, the induction of
CC       neuronal cell differentiation, and the stimulation of acute-phase
CC       protein synthesis in hepatocytes. {ECO:0000256|ARBA:ARBA00024822}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the LIF/OSM family.
CC       {ECO:0000256|ARBA:ARBA00005971}.
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DR   RefSeq; XP_025841799.1; XM_025986014.1.
DR   AlphaFoldDB; A0A3Q7R6M9; -.
DR   STRING; 9627.ENSVVUP00000004444; -.
DR   KEGG; vvp:112909866; -.
DR   OrthoDB; 5301125at2759; -.
DR   Proteomes; UP000286640; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005146; F:leukemia inhibitory factor receptor binding; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0010646; P:regulation of cell communication; IEA:UniProt.
DR   GO; GO:0023051; P:regulation of signaling; IEA:UniProt.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR003624; Leukemia_IF.
DR   InterPro; IPR001581; Leukemia_IF/oncostatin.
DR   InterPro; IPR019827; Leukemia_IF/oncostatin_CS.
DR   PANTHER; PTHR10633; LEUKEMIA INHIBITORY FACTOR; 1.
DR   PANTHER; PTHR10633:SF0; LEUKEMIA INHIBITORY FACTOR; 1.
DR   Pfam; PF01291; LIF_OSM; 1.
DR   PRINTS; PR01883; LEUKAEMIAIF.
DR   SMART; SM00080; LIF_OSM; 1.
DR   SUPFAM; SSF47266; 4-helical cytokines; 1.
DR   PROSITE; PS00590; LIF_OSM; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW   Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
SQ   SEQUENCE   219 AA;  24025 MW;  3A3439DA631C78FF CRC64;
     MKARSSQGKT ELEVELGHWC PWGGVVPLLL VLHWKHGAGS PLPITPVNAT CATRHPCHSN
     LMNQIRNQLA QLNGSANALF ILYYTAQGEP FPNNLDKLCG PNVTDFPPFH ANSTEKTRLV
     ELYRIIAYLG ASLGNITRDQ KVLNPNALSL HSKLNATADI MRGLLSNVLC RLCSKYHVAH
     VDVAYGPDTS GKDVFQKKKL GCQLLGKYKQ VIAVVAQAF
//
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