ID A0A3Q7R8I4_VULVU Unreviewed; 1617 AA.
AC A0A3Q7R8I4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Protein polybromo-1 isoform X10 {ECO:0000313|RefSeq:XP_025842384.1};
GN Name=PBRM1 {ECO:0000313|RefSeq:XP_025842384.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025842384.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025842384.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025842384.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025842384.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_025842384.1; XM_025986599.1.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0016586; C:RSC-type complex; IEA:InterPro.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR CDD; cd04717; BAH_polybromo; 2.
DR CDD; cd05524; Bromo_polybromo_I; 1.
DR CDD; cd05517; Bromo_polybromo_II; 1.
DR CDD; cd05520; Bromo_polybromo_III; 1.
DR CDD; cd05518; Bromo_polybromo_IV; 1.
DR CDD; cd05515; Bromo_polybromo_V; 1.
DR CDD; cd05526; Bromo_polybromo_VI; 1.
DR CDD; cd21984; HMG-box_PB1; 1.
DR Gene3D; 2.30.30.490; -; 2.
DR Gene3D; 1.20.920.10; Bromodomain-like; 6.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR037968; PBRM1_BD5.
DR InterPro; IPR037382; Rsc/polybromo.
DR PANTHER; PTHR16062:SF19; PROTEIN POLYBROMO-1; 1.
DR PANTHER; PTHR16062; SWI/SNF-RELATED; 1.
DR Pfam; PF01426; BAH; 2.
DR Pfam; PF00439; Bromodomain; 6.
DR Pfam; PF00505; HMG_box; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00439; BAH; 2.
DR SMART; SM00297; BROMO; 6.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47370; Bromodomain; 6.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS51038; BAH; 2.
DR PROSITE; PS00633; BROMODOMAIN_1; 5.
DR PROSITE; PS50014; BROMODOMAIN_2; 6.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640}.
FT DOMAIN 85..155
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 221..291
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 421..491
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 574..644
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 712..782
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 853..898
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 991..1109
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT DOMAIN 1191..1307
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT DOMAIN 1414..1464
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 1414..1464
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 22..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 176..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 661..682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 938..976
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1141..1168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1389..1413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..42
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 661..675
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 938..968
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1617 AA; 186043 MW; 652575B37B12A0DA CRC64;
MRRLAFRGAG CALVKLKKLD SMGSKRRRAT SPSSSVSGDF DDGHHSVSTP GPSRKRRRLS
NLPTVDPIAV CHELYNTIRD YKDEQGRLLC ELFIRAPKRR NQPDYYEVVS QPIDLMKIQQ
KLKMEEYDDV NLLTADFQLL FNNAKAYYKP DSPEYKAACK LWDLYLRTRN EFVQKGEADD
EDDDEDGQDN QGTVTEGSSP SYLKEILEQL LEAIVVATNP SGRLISELFQ KLPSKVQYPD
YYAIIKEPID LKTIAQRIQN GSYKSIHAMA KDIDLLAKNA KTYNEPGSQV FKDANSIKKI
FYMKKAEIEH HEMTKSSLRM RTPSNLAAAR LTGPSHSKGS LGEERNPTSK YYRNKRTVQG
GRLSAITMAL QYGSESEEDA ALAAARYEEG ESEAESITSF MDVSNPFYQL YDTVRSCRNN
QGQLIAEPFF HLPSKKKYPD YYQQIKMPIS LQQIRTKLKN QEYETLDHLE CDLNLMFENA
KRYNVPNSAI YKRVLKLQQV MQAKKKELAR RDDIEDGDSM ISSATSDAGS AKRKRNTLDS
EMLGLRRLSS KKNIRKQRMK ILFNVVLEAR EPGSGRRLCD LFMVKPSKKD YPDYYKIILE
PMDLKIIEHN IRNDKYAGEE GMIEDMKLMF RNARHYNEEG SQVYNDAHIL EKLLKDKRKE
LGPLPDDDDV ASPKLKLSRK SGISPKKSKY MTPMQQKLNE VYEAVKNYTD KRGRRLSAIF
LRLPSRSELP DYYLTIKKPM DMEKIRSHMM ANKYQDIDSM VEDFVMMFNN ACTYNEPESL
IYKDALVLHK VLLETRRDLE GDEDSHVPNV TLLIQELIHN LFVSVMSHQD DEGRCYSDSL
AEIPAVDPNF PNKPPLTFDI IRKNVENNRY RRLDLFQEHM FEVLERARRM NRTDSEIYED
AVELQQFFIK IRDELCKNGE ILLSPALSYT TKHLHNDVEK EKKEKLPKEL EEDKLKREEE
KRAEKSEDSS GATGLSGLHR TYSQDCSFKN SMYHVGDYVY VEPAEASLQP HIVCIERLWE
DSAGEKWLYG CWFYRPNETF HLATRKFLEK EVFKSDYYNK VPVSKILGKC VVMFVKEYFK
LCPENFRDED VFVCESRYSA KTKSFKKIKL WTMPISSVRF VPRDVPLPVV RVASVFANAD
KGDDEKNTDN SEDSRTEDSY NLEKEKEDVP VEMSNGEPGC HYFEQLRYND MWLKVGDCVF
IKSHGLVRPR VGRIEKVWVR DGAAYFYGPI FIHPEETEHE PTKMFYKKEV FLSNLEETCP
MTCILGKCAV LSFKDFLSCR PTEIPENDIL LCESRYNESD KQMKKFKGLK RFSLSAKVVD
DEIYYFRKPI VPQKEPSPLL EKKIQLLEAK FAELEGGDDD IEEMGEEDSE VIEPPSLPQL
QTPLASELDL MPYTPPQSTP KSAKGSAKKE GSKRKINMSG YILFSSEMRA VIKAQHPDYS
FGELSRLVGT EWRNLETAKK AEYEGVMNQG VAPMVGTPAP GGSPYGQQVG VLGPPGQQAP
PPYPGPHPAG PPVIQQPTTP MFVAPPPKTQ RLLHSEAYLK YIEGLSAESN SISKWDQTLA
ARRRDVHLSK EQESRLPSHW LKSKGAHTTM ADALWRLRDL MLRDTLNIRQ AYNLENL
//
