ID   A0A3Q7REE3_VULVU        Unreviewed;       476 AA.
AC   A0A3Q7REE3;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=Cytosolic iron-sulfur assembly component 3 {ECO:0000256|ARBA:ARBA00039851};
DE   AltName: Full=Cytosolic Fe-S cluster assembly factor NARFL {ECO:0000256|ARBA:ARBA00041671};
DE   AltName: Full=Iron-only hydrogenase-like protein 1 {ECO:0000256|ARBA:ARBA00042668};
DE   AltName: Full=Nuclear prelamin A recognition factor-like protein {ECO:0000256|ARBA:ARBA00041553};
GN   Name=CIAO3 {ECO:0000313|RefSeq:XP_025840501.1};
OS   Vulpes vulpes (Red fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX   NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025840501.1};
RN   [1]
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (JAN-2019) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_025840501.1}
RP   IDENTIFICATION.
RC   STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025840501.1};
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_025840501.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Component of the cytosolic iron-sulfur protein assembly (CIA)
CC       complex, a multiprotein complex that mediates the incorporation of
CC       iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to
CC       negatively regulate the level of HIF1A expression, although this effect
CC       could be indirect. {ECO:0000256|ARBA:ARBA00037412}.
CC   -!- SIMILARITY: Belongs to the NARF family.
CC       {ECO:0000256|ARBA:ARBA00006596}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_025840501.1; XM_025984716.1.
DR   AlphaFoldDB; A0A3Q7REE3; -.
DR   STRING; 9627.ENSVVUP00000016831; -.
DR   Ensembl; ENSVVUT00000022166; ENSVVUP00000016831; ENSVVUG00000012398.
DR   KEGG; vvp:112909035; -.
DR   OMA; GYLHHVL; -.
DR   OrthoDB; 5477067at2759; -.
DR   Proteomes; UP000286640; Unplaced.
DR   GO; GO:0097361; C:CIA complex; IEA:Ensembl.
DR   GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR   GO; GO:0032364; P:intracellular oxygen homeostasis; IEA:Ensembl.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:Ensembl.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   Gene3D; 3.40.50.1780; -; 1.
DR   InterPro; IPR009016; Fe_hydrogenase.
DR   InterPro; IPR004108; Fe_hydrogenase_lsu_C.
DR   InterPro; IPR003149; Fe_hydrogenase_ssu.
DR   PANTHER; PTHR11615:SF322; CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 3; 1.
DR   PANTHER; PTHR11615; NITRATE, FORMATE, IRON DEHYDROGENASE; 1.
DR   Pfam; PF02906; Fe_hyd_lg_C; 1.
DR   Pfam; PF02256; Fe_hyd_SSU; 1.
DR   SMART; SM00902; Fe_hyd_SSU; 1.
DR   SUPFAM; SSF53920; Fe-only hydrogenase; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000286640}.
FT   DOMAIN          410..466
FT                   /note="Iron hydrogenase small subunit"
FT                   /evidence="ECO:0000259|SMART:SM00902"
SQ   SEQUENCE   476 AA;  52865 MW;  77D222128F49A52D CRC64;
     MASPFSGALQ LTDLDDFIGP SQDCIKPVKV DRRPGSGVAK IHIEDDGSYF QVSPDGGTQR
     LEKAKISLDD CLACSGCVTS AETVLITQQS HEELRKVLDA NKTAAPGQQR LVVVSVSPQS
     RASLAARFQL SPTDTARKLT AFFKKIGVHY VFDTAFSRSF SLLESQREFV QRFREQANST
     QALPVLTSAC PGWICYAEKT HGNFLIPYLS TARSPQQVMG SLVKDFFAQQ QHLTPDRIYH
     VTVMPCYDKK LEASRPDFFN QEHQTRDVDC VVTTGEVFKL LEEEGVSLSE LEPAPLDSLC
     SSMSAQEPSS HRGGGSGGYL EHVFQHAAWE LFGIHVDEVT YRPLRNKDFK EVTLEKEGRV
     LLHFAAAYGF RNIQNLVQKL KRGRCPYHYV EVMACPAGCL NGGGQLKAPD VPSKELLQQV
     EMLYGMVRTE VPEDVPGVQE LYRSWLQGEG SEQAGRLLHT SYHAVEKASS GLSIRW
//