ID A0A3Q7RFQ6_VULVU Unreviewed; 1391 AA.
AC A0A3Q7RFQ6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=NPC1-like intracellular cholesterol transporter 1 isoform X1 {ECO:0000313|RefSeq:XP_025844143.1};
GN Name=NPC1L1 {ECO:0000313|RefSeq:XP_025844143.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025844143.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025844143.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025844143.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025844143.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cholesterol(in) = cholesterol(out); Xref=Rhea:RHEA:39747,
CC ChEBI:CHEBI:16113; Evidence={ECO:0000256|ARBA:ARBA00034049};
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR RefSeq; XP_025844143.1; XM_025988358.1.
DR STRING; 9627.ENSVVUP00000016174; -.
DR Ensembl; ENSVVUT00000021267; ENSVVUP00000016174; ENSVVUG00000011887.
DR KEGG; vvp:112911694; -.
DR OMA; VSLHCQN; -.
DR OrthoDB; 2786103at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005319; F:lipid transporter activity; IEA:InterPro.
DR GO; GO:0030301; P:cholesterol transport; IEA:UniProt.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004765; NPC1-like.
DR InterPro; IPR032190; NPC1_N.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR NCBIfam; TIGR00917; 2A060601; 1.
DR PANTHER; PTHR45727; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR PANTHER; PTHR45727:SF3; NPC1-LIKE INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR Pfam; PF16414; NPC1_N; 1.
DR Pfam; PF02460; Patched; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 344..371
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 419..441
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 701..722
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 734..758
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 764..787
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 807..829
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 841..865
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 912..932
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1181..1200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1207..1227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1233..1253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1274..1298
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1310..1333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 700..865
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 1391 AA; 150695 MW; 92FC8FE7EC579718 CRC64;
MAATFEATLP RGHRATWTQF PAWPGPLCLS RTTEPPPAHP TLPTCPLIVR CDRPAPSPSS
VTPFLRMKAQ TLWRHPAPAG ASHWAPCTCP HCPEPPEALP GAGACSDVVP PRRPRVSCTH
PSTSLATALS TTSVGRTQSC LGDWRLCLTY PACPTRPPPV SLQLLSLETS LAVTKALLTR
CPTCSDNFVN LHCQNTCSPN QSLFINVTRV AGGGGGRPQA VVAYEAFYQD SFAQQTYDSC
SRVRIPAAAT LAVGTMCGVY GSTLCNAQRW LNFQGDTSNG LAPLDITFHL MEPGQALGSG
MQALTGEIRP CNESQGNGTA ACSCQDCAAS CPTIPQPQAL DSTFYLGGLA GGLALVIILC
SAFALLTTFL VGTHLASSCG KDKMPDPKAG MSLSDKLSLS TNVILSQCFQ NWGTWVASWP
LTILLVSIAV VLALSGGLAF VELTTDPVEL WSAPSSQARS EKAFHDQHFG PFLRTNQVIL
TAPNRPSYHY DSLLLGPKNF SGVLASDLLL ELLELQETLR HLQVWSPEEQ RHISLQDICF
APLNPHNASL SDCCINSLLQ YFQSNRTHLL LTANQTLTGQ TSQVDWRDHF LYCANAPLTF
KDGTALALSC MADYGGPVFP FLAVGGYKGK DYSEAEALIM TFSLNNYAPG DPRLAHAKLW
EAAFLEEMKA FQRRTAGTFQ VTFMAERSLE DEINRTTAED LPIFGVSYII IFLYISLALG
SYSSWRRVPV DSKVTLGLGG VAVVLGAVTA AMGFFSYLGV PSSLVILQVV PFLVLAVGAD
NIFIFVLEYQ RLPRRPGERR EAHIGRALGS VAPSMLLCSL SEAICFFLGA LTPMPAVKTF
ALTSGFAIVL DFLLQVSAFV ALLSLDSRRQ EASRLDVCCC VSAPKLPAPG QSEGLLLRVF
RKFYVPVLLH RVTRVVVLLL FTGLFGVGLY FMCHIRVGLD QELALPKDSY LLDYFFFLNR
YFEVGAPVYF VTTGGYNFSS EAGMNAVCSS AGCDSYSLTQ KIQYATEFPE ESYLAIPASS
WVDDFIDWLT PSSCCRLYAF GANKDKFCPS TVNSLACLKN CVNFTLGPVR PSVDQFHKYL
PWFLSDPPNI KCPKGGLAAY NTSVHLGSDG QVLASRFMAY HKPLRNSEDY TEALRVSRAL
AANITAQLRQ VPGTDPAFEV FPYTITNVFY EQYLSVVPEG LFMLAICLLP TFVVCCLLLG
MDLRSGLLNL FSIVMILVDT VGFMALWGIS YNAVSLINLV TAVGISVEFV SHITRSFAVS
TQPTRLERAK ETTISMGSAV FAGVAMTNLP GILVLGLAKA QLIQIFFFRL NLLITILGLL
HGLVFLPVVL SYLGPDINAA LVLDQKKTEE AIGAPAHLVP TSTASYVNYG FQHPANGVVG
DSSLPGSGPD F
//
