ID A0A3Q7RIM1_VULVU Unreviewed; 509 AA.
AC A0A3Q7RIM1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Nectin-4 isoform X1 {ECO:0000313|RefSeq:XP_025842086.1};
GN Name=NECTIN4 {ECO:0000313|RefSeq:XP_025842086.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025842086.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025842086.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025842086.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025842086.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the nectin family.
CC {ECO:0000256|ARBA:ARBA00007810}.
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DR RefSeq; XP_025842086.1; XM_025986301.1.
DR AlphaFoldDB; A0A3Q7RIM1; -.
DR STRING; 9627.ENSVVUP00000021611; -.
DR Ensembl; ENSVVUT00000028669; ENSVVUP00000021611; ENSVVUG00000015884.
DR KEGG; vvp:112910059; -.
DR OrthoDB; 4235960at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005912; C:adherens junction; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR GO; GO:0046718; P:viral entry into host cell; IEA:InterPro.
DR CDD; cd00096; Ig; 1.
DR CDD; cd07704; IgC1_2_Nectin-3-4_like; 1.
DR CDD; cd05888; IgV_1_Nectin-4_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR033320; IgC1_2_Nectin-3-4-like.
DR PANTHER; PTHR23277:SF11; NECTIN-4; 1.
DR PANTHER; PTHR23277; NECTIN-RELATED; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..509
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018780135"
FT TRANSMEM 344..370
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 30..143
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 147..226
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 227..330
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 399..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..425
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..446
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 509 AA; 55169 MW; 2CD447604A6C17F0 CRC64;
MPLSLGAEMW GPEVLLLLLL LASFTGRCRP GELETSDLVT VVLGQDAKLP CFYRGDPGEQ
VGQVAWARVD AGEGARELAL LHSKYGLHVS AAYEGRVEQP PPPRSPLDGA VLLRNAVQAD
EGEYECRVST FPAGSFQARL RLRVLVPPLP SLNPGPALEE GQGLTLAASC TAEGSPAPSV
TWDTEVKGTA SSRSFKHSRS AAVTSEFHLV PSRSMNGQPL TCVVSHPGLL QDQRITHVLQ
VAFLAEASVR GLEDQKLWQV GREGATLKCL SEGHPPPSYN WTRLDGPLPS GVRVQGDTLG
FPPLTAEHSG TYVCHVSNEL SSRDSQVTVD VLDPEEAPGK QVDLVSASVV VVGVIAALLF
CLLVVVVVLM SRYHRRKAQQ MTQKYEEELT LTRENSIRRL HSHHSDPRSQ PEESVGLRAE
GHPDSLKDNS SCSVMSEEPE GRSYSTLTTV REIETQTELL SPGSGRAEDE EDRDEGIKQA
MNHFVQENGT LRAKPTGNGI YINGRGHLV
//
