ID A0A3Q7RK56_VULVU Unreviewed; 940 AA.
AC A0A3Q7RK56;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform X15 {ECO:0000313|RefSeq:XP_025846029.1};
GN Name=RUBCN {ECO:0000313|RefSeq:XP_025846029.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025846029.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025846029.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025846029.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025846029.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_025846029.1; XM_025990244.1.
DR AlphaFoldDB; A0A3Q7RK56; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR CDD; cd17686; RUN_RUBCN; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR InterPro; IPR025258; RH_dom.
DR InterPro; IPR048569; RUBC_PIKBD.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR PANTHER; PTHR45971; PHOX (PX) DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45971:SF3; RUN DOMAIN BECLIN-1-INTERACTING AND CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13901; RH_dom; 1.
DR Pfam; PF21054; RUBC_PIKBD; 1.
DR Pfam; PF02759; RUN; 1.
DR SMART; SM01175; DUF4206; 1.
DR SMART; SM00593; RUN; 1.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR PROSITE; PS50826; RUN; 1.
PE 4: Predicted;
KW Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640}.
FT DOMAIN 48..185
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT REGION 233..269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 283..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 533..557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..255
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..403
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..553
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 940 AA; 105349 MW; 85D5CF7DE2203427 CRC64;
MRPEGAGMDL GGCEERLPEA SRREHWQLLG NLKTTVEGLV SANSPNVWSK YGGLERLCRD
MQSILYHGLI HDQVCCRQTD YWQFVKDIRW LSPHSALHVE KFISLHENSQ SSTDGVSEHA
VAELWLQHSL QCHCLSAQLR PLLGDKQYIR KFYTDTAFLL SNAHVTAMLQ CLEAVEQNNP
RLLAQIDASM FARKHESPLL VTKSQSLTAL PGSTYTPPTS YAQHSYFGSF SSLHQSVPNH
GSERRSTSLS LSGPPRKPQE SREHVSPAQD QAFQASLLPV SALARDSSST PNEMSSSTLT
SPLEASWVSS QNDSPSDASE GPEYLAIGNL DPRGRTASCQ SHSSNAESSS SNLFSSSSSQ
KPDSAASSLG EQEGDGQSQL SSILRRSSFS EGQTLPATSG TKKSHTRSHS DTNIASRGAS
EGGQYLCSGE GMFRRPSEGQ SLISYLSEQD FGSCADLEKE NAHFSISESL IAAIELMKCN
MMSQCLEEEE EEEEDSDREI QELKQKIRLR RQQIRTKNLL PVYQETEHGS FRVTSSSSQF
SSRDSTQFSD SGSADEVDEF EIQDADIRRS TASHSKSFTS SQPFSHCFLH STSAEAVAMG
LLKQFEGMQL PAASELEWLV PEHDAPQKLL PIPDSLPISP DDGQHADIYK LRIRVRGNLE
WAPPRPQIIF NVHPAPTRKI AVAKQNYRCA GCGIRTDPDY IKRLRYCEYL GKYFCQCCHE
NAQVVIPSRV LRKWDFSKYY VSNFSKDLLI KIWNDPLFNV QDINSALYRK VKLLNQVRLL
RIQLYHMKNM FKTCRLAKEL LDSFDTVPGH LTEDLHLYSL NDLTATRKGE LGPRLAELTR
AGAAHVERCM LCQAKGFICE FCQNEEDIIF PFELHKCRTC EECKACYHKA CFKSGSCPRC
ERLQARRELL AKQSLESYMS DYEEEPTEAL ALEATVLEAT
//
