ID A0A3Q7RL42_VULVU Unreviewed; 2596 AA.
AC A0A3Q7RL42;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=POLQ {ECO:0000313|RefSeq:XP_025845928.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025845928.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025845928.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025845928.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025845928.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR RefSeq; XP_025845928.1; XM_025990143.1.
DR STRING; 9627.ENSVVUP00000030666; -.
DR KEGG; vvp:112913480; -.
DR OrthoDB; 208079at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006281; P:DNA repair; IEA:UniProt.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR CDD; cd18026; DEXHc_POLQ-like; 1.
DR CDD; cd08638; DNA_pol_A_theta; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.3380.20; -; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR019760; DNA-dir_DNA_pol_A_CS.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR046931; HTH_61.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR048960; POLQ-like_helical.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF20470; HTH_61; 1.
DR Pfam; PF21099; POLQ_helical; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR PROSITE; PS00447; DNA_POLYMERASE_A; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640}.
FT DOMAIN 107..291
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 326..561
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 912..934
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 949..968
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1047..1068
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1782..1806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 949..963
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2596 AA; 289125 MW; 8F9BFF9EC56E944E CRC64;
MNPPRRSGKR RRSASGSGSV SGSGGDDSDG LLAPRGPVLS PPPGLGRRCR DRGRLVAAAG
ECRQTVADDG TDQLLLANWG LPVAVLEKYH SYGVKRMFEW QAECLLLGQV LEGKNLVYSA
PTSAGKTLVA ELLMLKRVLE MRKKALFILP FVSVAKEKKY YLQSLFQEIG INVDGYMGST
SPTGHFSSLD IAVCTIERAN GLINRLIEEN KMDLLGMVVV DELHMLGDSH RGYLLELLLT
KICYITHKSA SCQADLASPL SNAVQIVGMS ATLPNLEIVA SWLNAELYHT NFRPVPLLES
VKIGNSIYDS SMKLVREFQP NLQVKGDEDH VVSLCYETIC DNHSVLIFCP SKKWCEKLAD
IIACEFYNLH HQATGKGLVR SSELPPVVLE QKGLLEVMDQ LKRSPSGLDS VLQKTIPWGV
AFHHAGLTFE ERDIIEGAFR QGQIRVLAAT STLSSGVNLP ARRVIIRTPI FGGQLLDILT
YKQMVGRAGR KGVDTVGESI LVCKNAEKSK GIALLQGSLK PVRSCLQRQK GEEVTASMIR
AILEIIVGGV ASTSQDMQTY ASCTFLAASM KEGKLGSQKN QDSVQLGAIE ACVMWLLENE
FIQITETGDG TEGKVYHPTH LGSATLSSSL SPTDTLDIFA DLQRAMKGFV LENDLHIVYL
VTPMFEDWAT IDWYRFFCLW EKLPTSMKRV AELVGVEEGF LARCVKGKVV ARTERQHRQM
AIHKRFFTSL VLLDLISEVP LKEINQKYGC SRGQIQSLQQ SAAVYAGMIT VFSNRLGWHN
MELLLSQFQK RLTFGIQREL CDLVRVSLLN AQRARFLYAS GFLTVADLAR ANIAEVEAVL
KNAVPFKSAR KAVDEEEEAA EERRHMRTIW VTGRKCLTDR EAAALIVEEA KMILQQDLVE
MGVQWNLHSL LNSDTQSSPS SESEVKEQKF VPQTNGSCKR LTLKKKSNSM FSDSSAKHSP
NTVQDLEKSG EHTDSFYCKL QNGNQEHQAH AISRARKQVS LNINREKLKT SLSEGRRHTK
KVVQTLLFEK TKKEALNFSS EKISTASGSW KHSKHVKRSR HSSPVKDTGM DRIDLQEQTM
SNPVYREDSF TLDGQNMEFR SPEPFGKNVT FCADGKYSKA SFSSQRKQRS KKKTKTSDIL
VEHFITRSQS KKVTYQPASM VSENGRGLVV ESEKINKEPM VQNDSKNQNV YIKHDTHSIN
QCPEKHSDKQ TNTYIKQKKV IEGQMPCETG SSYMNRDSNV IIKCGSTKFN GEENKTNNLQ
VSGDNISSDE ILGIHLPTGK SGQHENFLNT SRTQEKTEAY TANKTKNNCV SDLGLAPCEF
EDSFYLDTQS EKIIQQMATE NAKQGAKDAN PAIGTMQKNL DKQSSVNSFQ NEIHITFPGE
QHSPGVTNTD YLELKTVETV KQDTDSHGVG ILTPESLIFH SPILLRENGP CFKGNELSVT
DSQLNSFLQG YQTQETVKPV MPLVAQKRAT TGLEVECSPV PETSLNLSDN LLFDSFSEDY
LVKEQPPDIQ VKEPFSSELT SNHFSHSMCL QPEGPIRKSN TNENQDNQHQ FTCFSDESIL
FSEIDSAQMV EALDNVEICP VQEKLNTAIS LRALELSDPT TIGNGYPQRE VIGEDKDERF
QKPMLIETGE NNSFTWSGAS FDLSPGLQRI LDKVSSPLEN EKQKLTTTNL SSLKGKNTQF
NDKQKVISDL EPNQVEGISF SPNTEVKSKI GTLENNALHG ETSSLLPCKE NCIVDDIGLI
PPTPIPASAS KLVFPSTLET SVRFRNTQAV LQLGKSYSFG SSSNIKNQDL SSESRNGLED
DGPIRDTSFS LQLSQDGLQL TPASFSPESL AIIDVASDQT LFQTFIKEWQ CKNRFSISLA
CEKISNFTSS KSAAIGGRFK QVSSPQETPN RDDGIPVKGC DDILLVGLAV CWGGRDAYYF
SLQKEQKHPE ISSSLVPPSL DPSLTVKDRM WYLQSCFQEE SDKKRSIIIY DFIQSYKILL
LSCGISLEQS YEDPKVACWL LDPDSKEPTL HSIVSSFLPH ELLLLEGIET GQGIQSLGLN
VNTEHSGRYR ASVESILAFN AMNQLNSLLK KENLQDVFCK VEMPSQYCLA LLELNGIGFS
TAECESQKHI MQAKLDAIEI QAYQLAGHSF SFTSSDDIAE VLFLELKLPP NGEIKNQASK
KTLGSTRRGN DSRHKLRLGK QFSTSKDVLN KLKALHPLPG LILEWRRITN AITKVVFPLQ
REKRLNPFLG MERIYPVSQS HTATGRITFM EPNIQNVPRD FEIKMPILVG ESPPSQALAK
GLLPIYGRGR GKRSCGPNSG HQAQVEERAS DQGMPFSVSM RHAFVPFSGG LILAADYSQL
ELRILAHLSH DRRLIQVLNT GADVFRSIAA EWKMIEPESV GDDLRQQAKQ ICYGIIYGMG
AKSLGEQMGI KENDAACYIE SFKSRYTGIN HFMRETVKNC KRNGFVQTIL GRRRYLPGIN
DNNPYHKAHA ERQAINTTVQ GSAADIVKIA TVNIQKQLET FHSTFKSHGH REGMLQSERT
GLLPKRKQQG VLYPVRGGFL ILQLHDELFY EVAQEDVVQV AQIVKNEMER AIELSVKLKV
KVKIGVSWGD LKDFDV
//
