ID A0A3Q7RM83_VULVU Unreviewed; 4691 AA.
AC A0A3Q7RM83;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Plectin {ECO:0000313|RefSeq:XP_025843401.1};
GN Name=PLEC {ECO:0000313|RefSeq:XP_025843401.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025843401.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025843401.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025843401.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025843401.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_025843401.1; XM_025987616.1.
DR STRING; 9627.ENSVVUP00000030292; -.
DR KEGG; vvp:112911185; -.
DR OrthoDB; 5321591at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR CDD; cd21188; CH_PLEC-like_rpt1; 1.
DR CDD; cd21238; CH_PLEC_rpt2; 1.
DR CDD; cd00176; SPEC; 3.
DR Gene3D; 1.20.58.1060; -; 1.
DR Gene3D; 1.20.58.60; -; 4.
DR Gene3D; 3.30.160.780; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 3.90.1290.10; Plakin repeat; 6.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR041615; Desmoplakin_SH3.
DR InterPro; IPR041573; Desmoplakin_Spectrin-like.
DR InterPro; IPR049538; PCN-like_spectrin-like_rpt.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR035915; Plakin_repeat_sf.
DR InterPro; IPR005326; Plectin_eS10_N.
DR InterPro; IPR001101; Plectin_repeat.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR PANTHER; PTHR23169:SF20; PLECTIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00681; Plectin; 19.
DR Pfam; PF03501; S10_plectin; 1.
DR Pfam; PF17902; SH3_10; 1.
DR Pfam; PF18373; Spectrin_2; 1.
DR Pfam; PF21019; Spectrin_3; 1.
DR Pfam; PF21020; Spectrin_4; 1.
DR Pfam; PF21097; SR_plectin_7; 1.
DR SMART; SM00033; CH; 2.
DR SMART; SM00250; PLEC; 35.
DR SMART; SM00150; SPEC; 5.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF75399; Plakin repeat; 7.
DR SUPFAM; SSF46966; Spectrin repeat; 5.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 184..292
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 305..410
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 949..1006
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 144..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1626..1652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1744..1774
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1797..1848
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1913..1938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2089..2153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2220..2302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2675..2709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2763..2789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4629..4691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 803..830
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 902..932
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1243..1350
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1383..1437
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 155..172
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1804..1842
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2221..2264
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2691..2709
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4629..4675
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4691 AA; 532750 MW; EAE33D817476B10D CRC64;
MVAGMLMPRE QLRAVYEVLF REGVMVAKKD RRPRSLHPHV PGVTNLQVMR AMASLRARGL
VRETFAWRHF YWYLTNEGIA HLRQYLHLPP EIVPASLQRV RRPVAMVMPA RRTPHVQSVQ
GPLSCPPKWG PVPAEDPACE ERRVYRRKEP EEGAPEPPVV PATTPGNLAR PGPKPAPATD
ERDRVQKKTF TKWVNKHLIK HWRAEAQRHI SDLYEDLRDG HNLISLLEVL SGDSLPREKG
RMRFHKLQNV QIALDYLRHR QVKLVNIRND DIADGNPKLT LGLIWTIILH FQISDIQVSG
QSEDMTAKEK LLLWSQRMVE GYQGLRCDNF TSSWRDGRLF NAIIHRHRPM LIDMSKVYRQ
TNLENLDQAF SVAERDLGVT RLLDPEDVDV PQPDEKSIIT YVSSLYDAMP RVPDVQDGVK
ANELQLRWQE YRELVVLLLQ WMRHHTAAFE ERRFPSSFEE IEILWCQFLK FKETELPAKE
ADKNRSKGIY QSLEGAVQAG QLKVPPGYHP LDVEKEWGKL HVAILDREKQ LRSEFERWAG
VRVGEAAVGG APGQREATRG PEVVGATLQD VRLLAASKAP QRAAEVERDL DKADGMIRLL
FNDVQTLKDG RHPQGEQMYR RVYRLHERLV AIRTEYNLRL KSGVAAPVTQ VTVQTTQRRP
ELEDATLRYL QDLLAWVEEN QRRVDSAEWG GDLPSVEAQL GSHRGLHQSI DEFRAKIERA
RADEGQLSPA PRGTYRDCLG RLDLQYAKLL NSSKARLRSL ESLHGFVAAA TKELMWLSEK
EEEEVGFDWG EHNSNMAGKK ESYSALMREL EVKEKKIKEI QSTGDRLLRE GHPARPTVES
FQAALQTQWS WMLQLCCCIE AHLKENTAYF QFFSDVRETE EQLRKLQETL RRKYTCDRSI
TVTRLEDLLQ DAQDEKEQLN EYRAHLSGLA KRARAVVQLK PRDQAQPVRG RVPLQAVCDY
KQVEVTVHKG DQCQLLGPAQ PAHWKVLSSS GSEAAVPSVC FLVPPPNQEA QEAVSRLEAQ
HQALVALWHQ LHVDMKSLLA WQCLSRDVQL IRSWSLVTFR TLKPEEQRQA LRSLELHYQA
FLRDSQDAGG FGPEDRLQAE REYGSCSRHY QQLLQSAEQG AQEESRCQRC ISELKDIRLQ
LEACETRTVH RLRLPLDKEP ARECAQRIAE QQKAQAEVEG LGKGVARLSA EAEKVLALPE
PSPAAPTLRS ELELTLGKLE QVRSLSAIYL EKLKTISLVI RSTQGAEEVL RAHEEQLKEA
QAVPATLPEL EATKAALKKL RVQAEAQQPV FDALRDELRG AQEVGERLQR QHGERDVEVE
RWRERVAPLL ERWQAALAQT DVRQRELEQL GRQLRYYRES ADPLGAWLQD AKQRQERIQA
VPLANSQAVR EQLQQEKELL EEIERYGEKV DECQQLAKQY INAIKDYELQ LVTYKAQLEP
VASPAKKPKV QSGSESVIQE YVDLRTRYSE LTTLTSQYIK FIRETLRRME EEERLAEQQR
AEERERLAEV EAALEKQRQL AEAHAQAKAQ AEREAEELQR RMQEEVARRE EAAVDAQQQK
RSIQEELQHL RQSSEAEIQA KARQVEAAER SRVRIEEEIR VVRLQLEATE RQRGGAEGEL
QALRARAEEA EAQKRQAQEE AERLRRQVQD ESQRKRQAEA ELALRVKAXE AAREKQRALQ
ALEDVRLQAE EAERRLRQAE ADRARQVQVA LETAQRSAEV ELQSKRASFA EKTAQLERTL
QEEHVAVAQL REEAERRAQQ QAEAERAREE AEQELERWRL KANEALRLRL QAEEVAQQKS
LAQAEAEKQK EEAEREARRR GKAEEQAVRQ RELAEQELEK QRQLAEGTAQ QRLVAEQELI
RLRAETEQGE QQRQLLEEEL ARLQREAAAA THKRQELEAE LAKVRAEMEV LLASKARAEE
ESRSTSEKSK QRLEAEASRF RELAEEAARL RALAEETKRQ RQLAEEDAAR QRAEAERVLA
EKLAAISEAT RLKTEAEIAL KEKEAENERL RRLAEDEAFQ RRRLEEQAAQ HKADIEERLA
QLRKASENEL ERQKGLVEDT LRQRRQVEEE ILALKASFEK AAAGKAELEL ELGRIRSNAE
DTLRSKEQAE LEATRQRQLA AEEEQRRREA EERVQKSLAA EEEAARQRKS ALEEVERLKA
KVEEARRLRE RAEQESARQL QLAQEAAQKR LQAEEKAHAF AVQQKEQELQ QTLQQEQSML
ERLRAEAEAA RRAAEEAEEA RERAEREAAQ SRRQVEEAER LKQLAEEQAQ AQAQAQAAAE
KLRKEAEQEA ARRAQAEQAA LKQKQVADAE MEKHKKFAEQ TLRQKAQVEQ ELTTLRLQLE
ETDHQKSILD EELQRLKAEV TEAARQRNQV EEELFSVRVQ MEELSKLKAR IEAENRALIL
RDKDNTQRFL QEEAEKMKQV AEEAARLSVA AQEAARLRQL AEEDLAQQRA LAEKMLKEKM
QAVQEATRLK AEAELLQQQK ELAQEQARQL QEDKEQMAQQ LAQETQGFQR TLEAERQRQL
EMSAEAERLK LRVAEMSRAQ ARAEEDAQRF RKQAEEIGEK LHRTELATQE KVTLVHTLEI
QRQQSDHDAE RLRAAIAELE REKEKLQEEA TLLQQKSEEM QVVQQEQLLQ ETRALQESFL
SEKDRLLQRE RFIEQEKAKL EQLFRDEVAK AQKLREEQQR QQQQMEQERE QLVASMEEAR
QRQREAEEGV RRKQEELQLL EQQRQQQERL LAEENQRLRE RLQRLEEEHR AALAHSEEIA
ASQAAASKAL PNGRDALDGP AAEAEPEHAF DGLRRKVPAQ RLQEVGILSA EELQRLAQGR
TTVAELAQRE DVRQYLQGRG GIAGLLLKPA NEKLSIYAAL RRQLLSPGTA LILLEAQAAT
GFLLDPVQNR RLTVNEAVKE GVVGPELHHK LLSAERAVTG YKDPYTGEQI SLFQAMKKEL
IVRDHGIRLL EAQIATGGII DPVHSHRLPV DVAYQRGYFD EEMNRVLADP SDDTKGFFDP
NTHENLTYLQ LLERCVLDPD TGLRLLPLTD QAARGGELVY TDSEARDVFE KATVSAPFGK
FQGRTVTIWE LINSEYFTAE QRRDLLRQFR TGKVTVEKII KIVITVVEEH EQKGQLCFEG
LRALVPAAEL LESGVIDHNL YRQLQRGERS VREVAEVDAV RRALRGTSVI AGVWLEEAGQ
RLSIYEALKK DLLPPEVAVA LLEAQAGTGH IIDPATSARL TVDEAVRAGL VGPELHEKLL
SAEKAVTGYK DPYSGQSVSL FQALKKGLIP REQGLRLLDA QLSTGGIVDP SKSHRVPTDV
AYARGYLDQE TSRALSAPQD EAKTYHDPGT QEPVTYGQLQ QQCRPDPLTG LSLLPLSEQA
AQARREGLYS ELQARETFQK TPVEVPVGSF KGRTVTVWEL LSSEYFTAEQ RQELLRQFRT
GTVTVEKIIK IVITIVEEVE TVRQERLSFS GLRAPVPASE LLASGVLSRT QFEQLKDGKT
SVKDLSELSS VRTLLQGSGC LAGIYLEDSK EKVTIYEAMR RGLLRPSTAT LLLEAQAATG
FLIDPVRNQR LYVHEAVKAG VVGPELHEKL LSAEKAVTGY KDPYSGSTIS LFQAMKKGLV
LREHGIRLLE AQIATGGIID PVHSHRLPVD VAYQRGYFDE EMNRVLADPS DDTKGFFDPN
THENLTYLQL LERCVEDPET GLRLLPLKGA EKTEVVETTQ VYTEEETRRA FEETQIDIPG
SAGRGGSTMS LWEVMQSDLI PEEQRTRLMA DFQAGRVTKE RMIIIIIEII EKTEIVRQQN
LASYDYVRRR LTAEDLYEAR IISRETYSLL REGTKSLRQV LEEEEASRYL YGTGCVAGVY
LPGSRQTLTI YQALKKGLLN AEVARFLLEA QAATGFLLEP VKGERLTVDE AVRKGLVGPE
LHDRLLSAER AVTGYRDPYT EQTISLFQAM KKDLIPTDEA LRLLDAQLAT GGIVDPHLGF
HLPLEVAYQR GYLNKDTHDQ LSEPSEVRSY LDPSTDERLS YTQLLRRCRR HETSGQMLLP
LSDARKLTFR GLRKQITVEE LVRSQVLDEA TALQLQEGLT SVEEVTKNLQ KFLEGTSCIA
GVFVDATKER LSVYQAMKKG IIRPGTAFEL LEAQAATGYV IDPIKGLKLT VEEAVRMGIV
GPEFKDKLLS AERAVIGYKD PYSGKLISLF QAMKKGLILK DHGIRLLEAQ IATGGIIDPE
ESHRLPVEVA YKRGLFDEEM NEILTDPSDD TKGFFDPNTE ENLTYLQLME RCITDPQTGL
CLLPLKEKKR ERKTSSKSSV RKRRVVIVDP ETGKEMSVYE AYRKGLIDHQ TYLELSEQEC
EWEEITISSS DGVVKSMIID RRSGRQYDID EAIARNLIDR SALDQYRAGT LSITEFADML
SGNAGGFRSR SSSVGSSSSY PISPAASRTQ AASWSDPTEE TGPVAGILDT ETLEKVSITE
AMRRNLVDNI TGQRLLEAQA CTGGIIDPSS GERFPVTDAV SRGLVDKIMV DRINLAQKAF
CGFEDPRTKT KMSAAQALKK GWLYYEAGQR FLEAQYLTGG LIEPDVPGRV PLDEALQRGM
VDARTAQKLR DVGAYSKYLT CPKTKLKISY KDALDRSMVE EGTGLRLLEA AAQSTKGYYS
PYSVSGSGSA AGSRSGSRTG SRAGSRRGSF DATGSGFSMT FSSSSYSSSG YGRRYASGPV
SSLGGPESAA A
//
