ID A0A3Q7RPH0_VULVU Unreviewed; 198 AA.
AC A0A3Q7RPH0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Synaptobrevin homolog YKT6 isoform X1 {ECO:0000313|RefSeq:XP_025844131.1};
GN Name=YKT6 {ECO:0000313|RefSeq:XP_025844131.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025844131.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025844131.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025844131.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025844131.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Vesicular soluble NSF attachment protein receptor (v-SNARE)
CC mediating vesicle docking and fusion to a specific acceptor cellular
CC compartment. Functions in endoplasmic reticulum to Golgi transport; as
CC part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in
CC early/recycling endosome to TGN transport; as part of a SNARE complex
CC composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase
CC activity. {ECO:0000256|ARBA:ARBA00025256}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00025701}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00025701}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00025701}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004444}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004444}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004444}. Membrane
CC {ECO:0000256|ARBA:ARBA00004423}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004423}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004423}.
CC -!- SIMILARITY: Belongs to the synaptobrevin family.
CC {ECO:0000256|ARBA:ARBA00008025}.
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DR RefSeq; XP_025844131.1; XM_025988346.1.
DR AlphaFoldDB; A0A3Q7RPH0; -.
DR STRING; 9627.ENSVVUP00000011562; -.
DR Ensembl; ENSVVUT00000015153; ENSVVUP00000011562; ENSVVUG00000008511.
DR KEGG; vvp:112911692; -.
DR OMA; HYIGIIR; -.
DR OrthoDB; 24529at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0005768; C:endosome; IEA:Ensembl.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IEA:Ensembl.
DR GO; GO:0005484; F:SNAP receptor activity; IEA:Ensembl.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:Ensembl.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:Ensembl.
DR GO; GO:0006904; P:vesicle docking involved in exocytosis; IEA:Ensembl.
DR GO; GO:0006903; P:vesicle targeting; IEA:Ensembl.
DR CDD; cd14824; Longin; 1.
DR CDD; cd15867; R-SNARE_YKT6; 1.
DR Gene3D; 1.20.5.110; -; 1.
DR Gene3D; 3.30.450.50; Longin domain; 1.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR InterPro; IPR010908; Longin_dom.
DR InterPro; IPR045848; R-SNARE_YKT6.
DR InterPro; IPR042855; V_SNARE_CC.
DR PANTHER; PTHR45806; SYNAPTOBREVIN HOMOLOG YKT6; 1.
DR PANTHER; PTHR45806:SF1; SYNAPTOBREVIN HOMOLOG YKT6; 1.
DR Pfam; PF13774; Longin; 1.
DR Pfam; PF00957; Synaptobrevin; 1.
DR SMART; SM01270; Longin; 1.
DR SUPFAM; SSF58038; SNARE fusion complex; 1.
DR SUPFAM; SSF64356; SNARE-like; 1.
DR PROSITE; PS50859; LONGIN; 1.
DR PROSITE; PS50892; V_SNARE; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU00290};
KW ER-Golgi transport {ECO:0000256|ARBA:ARBA00022892};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Prenylation {ECO:0000256|ARBA:ARBA00023289};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Transport {ECO:0000256|ARBA:ARBA00022892}.
FT DOMAIN 8..131
FT /note="Longin"
FT /evidence="ECO:0000259|PROSITE:PS50859"
FT DOMAIN 138..198
FT /note="V-SNARE coiled-coil homology"
FT /evidence="ECO:0000259|PROSITE:PS50892"
SQ SEQUENCE 198 AA; 22377 MW; A31F116D922EE4B2 CRC64;
MKLYSLSVLY KGEPKAVLLK AAYDVSSFSF FQRSSVQEFM TFTSQLIVER SAKGSRASVK
EQEYLCHVYV RNDSLAGVVI ADSEYPSRVA FTLLEKVLDE FSKQVDRIEW PVGSPASIHY
TALDGHLSRY QNPREADPMT KVQAELDETK IILHNTMESL LERGEKLDDL VSKSEVLGTQ
SKAFYKTARK QNSCCAIM
//
