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Database: UniProt
Entry: A0A3Q7RS42_VULVU
LinkDB: A0A3Q7RS42_VULVU
Original site: A0A3Q7RS42_VULVU 
ID   A0A3Q7RS42_VULVU        Unreviewed;       836 AA.
AC   A0A3Q7RS42;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=dolichyl-phosphate-mannose--protein mannosyltransferase {ECO:0000256|ARBA:ARBA00012839};
DE            EC=2.4.1.109 {ECO:0000256|ARBA:ARBA00012839};
GN   Name=TMTC2 {ECO:0000313|RefSeq:XP_025847978.1};
OS   Vulpes vulpes (Red fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX   NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025847978.1};
RN   [1]
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (JAN-2019) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_025847978.1}
RP   IDENTIFICATION.
RC   STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025847978.1};
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_025847978.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC       {ECO:0000256|ARBA:ARBA00004922}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC       {ECO:0000256|ARBA:ARBA00004240}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the TMTC family.
CC       {ECO:0000256|ARBA:ARBA00007882}.
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DR   RefSeq; XP_025847978.1; XM_025992193.1.
DR   AlphaFoldDB; A0A3Q7RS42; -.
DR   STRING; 9627.ENSVVUP00000015031; -.
DR   Ensembl; ENSVVUT00000019734; ENSVVUP00000015031; ENSVVUG00000011020.
DR   KEGG; vvp:112914887; -.
DR   OrthoDB; 155869at2759; -.
DR   UniPathway; UPA00378; -.
DR   Proteomes; UP000286640; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0004169; F:dolichyl-phosphate-mannose-protein mannosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0055074; P:calcium ion homeostasis; IEA:Ensembl.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR   InterPro; IPR013618; TMTC_DUF1736.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR001440; TPR_1.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR44216; PROTEIN O-MANNOSYL-TRANSFERASE TMTC2; 1.
DR   PANTHER; PTHR44216:SF3; PROTEIN O-MANNOSYL-TRANSFERASE TMTC2; 1.
DR   Pfam; PF08409; TMTC_DUF1736; 1.
DR   Pfam; PF00515; TPR_1; 1.
DR   Pfam; PF13424; TPR_12; 1.
DR   Pfam; PF13432; TPR_16; 1.
DR   Pfam; PF13181; TPR_8; 1.
DR   SMART; SM00028; TPR; 8.
DR   SUPFAM; SSF48452; TPR-like; 2.
DR   PROSITE; PS50005; TPR; 6.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW   TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW   ProRule:PRU00339};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..836
FT                   /note="dolichyl-phosphate-mannose--protein
FT                   mannosyltransferase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018691593"
FT   TRANSMEM        132..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        168..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        191..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        221..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        311..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        393..417
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        423..443
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        450..468
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          248..320
FT                   /note="DUF1736"
FT                   /evidence="ECO:0000259|Pfam:PF08409"
FT   REPEAT          493..526
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          527..560
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          561..594
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          606..639
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          677..710
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          779..812
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ   SEQUENCE   836 AA;  93617 MW;  EED5F4BEA01F5245 CRC64;
     MLAELVSSAL GLALYLNTLS ADFCYDDSRA IKTNQDLLPE TPWTHIFYND FWGTLLTHSG
     SHKSYRPLCT LSFRLNHAVG GLDPWSYHLV NVLLHAAVTG VFTSFSKTLL GDGCWTFMAG
     LLFASHPIHT EAVAGIVGRA DVGASLFFLL SLLCYIKHCS TRGSSARTWG WFLGTGLCAG
     CSMLWKEQGV TVLAVSAVYD VFVFHRLKVK QILPAICKRK NLSLFLSISL LTFWGTSLLG
     ARLYWMGNKP PSFSNSDNPA ADSDSLLART LTFFYLPTKN LWLLLCPDTL SFDWSMDAVP
     LLRTVCDWRN LHTVAFYTGL LLLAYYGLKS PGVERECNGK VVTNGKQNAN GHSCHSDGEY
     RNSESKPSLA AKAENGIKNN AAQRSPLPST ENIVVLSLSL LIIPFVPATN LFFYVGFVIA
     ERVLYIPSMG FCLLVTVGAR ALYVKVQKRF LKSLIFYATA TLIVFYGLKT AIRNGDWQNE
     EMLYRSGIKV NPAKAWGNLG NVLKSQSKIS EAESAYRNAL YYRSNMADML YNLGLLLQEN
     SRFAEALHYY KLAIGSRPTL ASAYLNTGII LMNQGKTEEA RRTFLKCSEI PDENLKDPHA
     HKSSVTSCLY NLGKLYHEQG HYEDALSVYK EAIQKMPRQF APQSLYNMMG EAYMRLSKLP
     EAEHWYMESL RSKTDHIPAH LTYGKLLALT GRKSEAEKFF LKAIELDPTK GNCYMHYGQF
     LLEEARLIEA AEMAKKAAEL DSTEFDVVFS AAHMLRQASL NEAAEKYYDL AARLRPNYPA
     ALMNLGAILH LNGRLQKAEA NYLRALQLKP DDVITQSNLR KLWNIMEKQG LKTSKT
//
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