ID A0A3Q7RSA6_VULVU Unreviewed; 938 AA.
AC A0A3Q7RSA6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Ephrin type-A receptor 10 {ECO:0000313|RefSeq:XP_025848028.1};
GN Name=EPHA10 {ECO:0000313|RefSeq:XP_025848028.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025848028.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025848028.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025848028.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025848028.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_025848028.1; XM_025992243.1.
DR AlphaFoldDB; A0A3Q7RSA6; -.
DR STRING; 9627.ENSVVUP00000031824; -.
DR KEGG; vvp:112914936; -.
DR OrthoDB; 1614410at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005003; F:ephrin receptor activity; IEA:InterPro.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.1770; ephrin a2 ectodomain; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 1.
DR InterPro; IPR027936; Eph_TM.
DR InterPro; IPR001090; Ephrin_rcpt_lig-bd_dom.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR016257; Tyr_kinase_ephrin_rcpt.
DR InterPro; IPR001426; Tyr_kinase_rcpt_V_CS.
DR PANTHER; PTHR46877; EPH RECEPTOR A5; 1.
DR PANTHER; PTHR46877:SF16; EPHRIN TYPE-A RECEPTOR 10; 1.
DR Pfam; PF14575; EphA2_TM; 1.
DR Pfam; PF01404; Ephrin_lbd; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF00536; SAM_1; 1.
DR PIRSF; PIRSF000666; TyrPK_ephrin_receptor; 2.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00615; EPH_lbd; 1.
DR SMART; SM01411; Ephrin_rec_like; 1.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS51550; EPH_LBD; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00790; RECEPTOR_TYR_KIN_V_1; 1.
DR PROSITE; PS00791; RECEPTOR_TYR_KIN_V_2; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRSR:PIRSR000666-
KW 2}; Disulfide bond {ECO:0000256|PIRSR:PIRSR000666-3};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRSR:PIRSR000666-2};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_025848028.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022989};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 34..938
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018653328"
FT DOMAIN 35..216
FT /note="Eph LBD"
FT /evidence="ECO:0000259|PROSITE:PS51550"
FT DOMAIN 386..484
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 575..830
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 863..927
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 397..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 581..589
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000666-2"
FT DISULFID 77..198
FT /evidence="ECO:0000256|PIRSR:PIRSR000666-3"
FT DISULFID 112..122
FT /evidence="ECO:0000256|PIRSR:PIRSR000666-3"
SQ SEQUENCE 938 AA; 102085 MW; 41A6847113D3EFC0 CRC64;
METGAGARPL RLLGCLMPLC LALLLGPGRP GTAEEVILLD SKASQAELGW TALPSNGWEE
ISGVDEHDRP IRTYQVCNVL EPNQDNWLQT GWISRGPGQR IFVELQFTLR DCSSIPGAAG
TCKETFNVYY LETEADLGRG RPRPGGSRAR KIDTIAADES FTQGDLGERK MKLNTEVREV
GPLSRRGFHL AFQDVGACVA LVSVRVYYKQ CRATVRGLAA FPATAAESAF STLVEVTGTC
VAHSEGEPGS PPRMHCGADG EWLVPVGRCS CSAGFQERGD ICEACPPGFY KLSSSRPLCS
PCPEHSHALE NASTFCVCQD SYARSPTDPP SASCTRECPD AKGENSRLWL WVWRMPCPCP
CPCPRWHPAV GSRGDPPPSL LSAPWEEDEI RRDRVEPQSV SLSWREPVPA GAPGANGTEY
EIRYYEKGQS EQTYSTVKTG APAVTVTNLK PATRYVFQIR AASPGPSWET QSFNPSIEVQ
TPGEAASRPR DHNPAVVVTV VTISALLVLG SVMSVLAMWR RPCPYGKGGQ DAHDEEELYF
HFKVPTRRTF LDPQSCGDPL QAVHLFAKEL DAKTVTLEKS LGAGRFGELS FGCLQLPGRQ
ELPVAVHTLR DGCSDSQRLS FLAEALTLGQ FDHSHVVRLE GVITRGSTLM IVTEYMSHGA
LDSFLRRHEG QLAAGQLLGL LPGLASAMKY LSEMGYVHRG LAARRVLVTS GLICKISGFG
RGPRDRAEAV YTTMSGRSPA LWAAPETLQF GHFSSASDVW SFGVVMWEVM AFGERPYWDM
SGQDVIKAVE DGFRLPPPRH CPSLLHRLML DCWQKDPGER PRFSQIHSIL SKMVQDPEPP
KCATATSPRP PTPLADRAFS TFPSFGSVGA WLDALDLGRY KDSFAAGGYG SLEAVAAMAA
QDLLNLGISS AEHREALLSG ISALRARVLQ LQGQGVQV
//
