ID A0A3Q7RV63_VULVU Unreviewed; 851 AA.
AC A0A3Q7RV63;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Catenin alpha-2 {ECO:0000256|ARBA:ARBA00023806};
DE AltName: Full=Alpha N-catenin {ECO:0000256|ARBA:ARBA00029822};
GN Name=CTNNA2 {ECO:0000313|RefSeq:XP_025850227.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025850227.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025850227.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025850227.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025850227.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, adherens junction
CC {ECO:0000256|ARBA:ARBA00004536}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004413}. Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the vinculin/alpha-catenin family.
CC {ECO:0000256|ARBA:ARBA00008376}.
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DR RefSeq; XP_025850227.1; XM_025994442.1.
DR AlphaFoldDB; A0A3Q7RV63; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:InterPro.
DR GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0045296; F:cadherin binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR Gene3D; 6.10.250.2510; -; 1.
DR Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 4.
DR Gene3D; 1.10.287.160; HR1 repeat; 1.
DR InterPro; IPR036723; Alpha-catenin/vinculin-like_sf.
DR InterPro; IPR001033; Alpha_catenin.
DR InterPro; IPR006077; Vinculin/catenin.
DR InterPro; IPR000633; Vinculin_CS.
DR PANTHER; PTHR18914; ALPHA CATENIN; 1.
DR PANTHER; PTHR18914:SF23; CATENIN ALPHA-2; 1.
DR Pfam; PF01044; Vinculin; 2.
DR PRINTS; PR00805; ALPHACATENIN.
DR SUPFAM; SSF47220; alpha-catenin/vinculin-like; 4.
DR PROSITE; PS00663; VINCULIN_1; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640}.
FT REGION 810..837
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 810..829
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 851 AA; 94132 MW; 2C82395F1D0CD6E9 CRC64;
MRIASSEFAD DPCSSVKRGT MVRAARALLS AVTRLLILAD MADVMRLLSH LKIVEEALEA
VKNATNEQDL ANRFKEFGKE MVKLNYVAAR RQQELKDPHC RDEMAAARGA LKKNATMLYT
ASQAFLRHPD VAATRANRDY VFKQVQEAIA GISNAAQATS PTDEAKGHTG IGELAAALNE
FDNKIILDPM TFSEARFRPS LEERLESIIS GAALMADSSC TRDDRRERIV AECNAVRQAL
QDLLSEYMNN TGRKEKGDPL NIAIDKMTKK TRDLRRQLRK AVMDHISDSF LETNVPLLVL
IEAAKSGNEK EVKEYAQVFR EHANKLVEVA NLACSISNNE EGVKLVRMAA TQIDSLCPQV
INAALTLAAR PQSKVAQDNM DVFKDQWEKQ VRVLTEAVDD ITSVDDFLSV SENHILEDVN
KCVIALQEGD VDTLDRTAGA IRGRAARVIH IINAEMENYE AGVYTEKVLE ATKLLSETVM
PRFAEQVEVA IEALSANVPQ PFEENEFIDA SRLVYDGVRD IRKAVLMIRT PEELEDDSDF
EQEDYDVRSR TSVQTEDDQL IAGQSARAIM AQLPQEEKAK IAEQVEIFHQ EKSKLDAEVA
KWDDSGNDII VLAKQMCMIM MEMTDFTRGK GPLKNTSDVI NAAKKIAEAG SRMDKLARAV
ADQCPDSACK QDLLAYLQRI ALYCHQLNIC SKVKAEVQNL GGELIVSGTG VQSTFTTFYE
VDCDVIDGGR ASQLSTHLPT CAEGAPIGSG SSDSSMLDSA TSLIQAAKNL MNAVVLTVKA
SYVASTKYQK VYGTAAVNSP VVSWKMKAPE KKPLVKREKP EEFQTRVRRG SQKKHISPVQ
ALSEFKAMDS F
//
