ID A0A3Q7RWZ0_VULVU Unreviewed; 905 AA.
AC A0A3Q7RWZ0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=ATP-dependent DNA helicase DDX11 {ECO:0000313|RefSeq:XP_025851207.1, ECO:0000313|RefSeq:XP_025851208.1};
GN Name=DDX11 {ECO:0000313|RefSeq:XP_025851207.1,
GN ECO:0000313|RefSeq:XP_025851208.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025851207.1};
RN [1]
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025851208.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025851208.1};
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025851207.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025851207.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025851207.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC DDX11/CHL1 sub-subfamily. {ECO:0000256|ARBA:ARBA00008435}.
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DR RefSeq; XP_025851207.1; XM_025995422.1.
DR RefSeq; XP_025851208.1; XM_025995423.1.
DR STRING; 9627.ENSVVUP00000025008; -.
DR Ensembl; ENSVVUT00000033127; ENSVVUP00000025057; ENSVVUG00000018329.
DR KEGG; vvp:112917400; -.
DR OMA; QTHQFRD; -.
DR OrthoDB; 124793at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR CDD; cd18788; SF2_C_XPD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR006554; Helicase-like_DEXD_c2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010614; RAD3-like_helicase_DEAD.
DR InterPro; IPR013020; Rad3/Chl1-like.
DR NCBIfam; TIGR00604; rad3; 1.
DR PANTHER; PTHR11472:SF41; ATP-DEPENDENT DNA HELICASE DDX11-RELATED; 1.
DR PANTHER; PTHR11472; DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER; 1.
DR Pfam; PF06733; DEAD_2; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR SMART; SM00488; DEXDc2; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000256|ARBA:ARBA00022806,
KW ECO:0000313|RefSeq:XP_025851207.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640}.
FT DOMAIN 9..443
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51193"
FT REGION 80..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 202..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 130..180
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 905 AA; 101989 MW; 4879F4F2EAD09883 CRC64;
MSNKTQEIGD IHFPFPFTPY SIQKDFMAEL YRVLEAGKIG IFESPTGTGK SLSVICGALS
WLRDFEQKKH QEEARLLKAG TIPLSDGKEQ PPPLSASCKR TPDTPSPAGE PDWVTEFVQK
KEERDLVDRL KEEQVRRKKR EERLQQIRHN AQLKYAAKRV RQEEEEMERL LRLSREMLAA
GTGAEPLEQL ASGEEELVLA EYESDEEKGA PSGVDEDEDD PEEEHVTKIY YCSRTHSQLA
QFVHEVQRSP FGKDTRLVSL GSRQNLCVNE DVKTLGSVQL INDRCMEMQR SKHENRAEEE
KPKRRRQEHQ ATCPFYNYEQ LQLLRDQVLV GVKDIEQLVT LGKEARACPY YGSRFAIPAA
QLVVLPYQML LHAATRQAAG IRLQGQVVVI DEAHNLIDTI TGIHSVEVSG SQLCQAHSQL
LQYMERYGKR LKAKNLMYIK QILYLLEKFV TVLGGNVKQN PNTQSLSQTG TELKTINDFL
FQTQIDNINL FKVRHYCEKS MISRKLFGFT ERYGIVLTPS REQPNLAGLQ HFLQSLQPTV
TKTPVTPVED GEARVPRPAS PLMHIESFLA ALTTANQDGR VILSRQGSLS QSSLKFLLLN
PAVHFAQVVK ECRAVVIAGG TMQPVSDFRE QLLACAGVEA ERVVEFSCGH VIPPDNILPL
IICSGPSSQQ LEFTYQKREL PQMMDETGRI LCNLCTVVPG GVVCFFPSYE YQRQVYAHWD
KSGLLARLAV RKKIFQEPKR ANQVEQVLME YSRCIKCCGQ AGGTVTGALL LSVVGGKMSE
GINFSDDLGR CVVMVGMPYP NIKSPELQEK MAYLDQTLPR VPGQPPPGKA LVENLCMKAV
NQSIGRAIRH QKDFASIVLL DQRYARPPIL GKLPAWIRDR VEVRATFGPA FATMRKFHRE
KSVPS
//
