ID A0A3Q7S0C0_VULVU Unreviewed; 186 AA.
AC A0A3Q7S0C0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial {ECO:0000256|ARBA:ARBA00020530, ECO:0000256|PIRNR:PIRNR009288};
DE AltName: Full=Complex I-ASHI {ECO:0000256|ARBA:ARBA00032752, ECO:0000256|PIRNR:PIRNR009288};
DE AltName: Full=NADH-ubiquinone oxidoreductase ASHI subunit {ECO:0000256|ARBA:ARBA00032699, ECO:0000256|PIRNR:PIRNR009288};
GN Name=NDUFB8 {ECO:0000313|RefSeq:XP_025848001.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025848001.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025848001.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025848001.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025848001.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000256|ARBA:ARBA00003195, ECO:0000256|PIRNR:PIRNR009288}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC {ECO:0000256|ARBA:ARBA00011533, ECO:0000256|PIRNR:PIRNR009288}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000256|ARBA:ARBA00004298}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004298}; Matrix side
CC {ECO:0000256|ARBA:ARBA00004298}.
CC -!- SIMILARITY: Belongs to the complex I NDUFB8 subunit family.
CC {ECO:0000256|ARBA:ARBA00008039, ECO:0000256|PIRNR:PIRNR009288}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_025848001.1; XM_025992216.1.
DR AlphaFoldDB; A0A3Q7S0C0; -.
DR STRING; 9627.ENSVVUP00000034528; -.
DR Ensembl; ENSVVUT00000045522; ENSVVUP00000034529; ENSVVUG00000024929.
DR KEGG; vvp:112914900; -.
DR OMA; PRYKNSY; -.
DR OrthoDB; 2940624at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:UniProtKB-UniRule.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:UniProtKB-UniRule.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; IEA:UniProtKB-UniRule.
DR InterPro; IPR008699; NDUFB8.
DR InterPro; IPR016551; Ndufb8_metazoa.
DR PANTHER; PTHR12840:SF1; NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 8, MITOCHONDRIAL; 1.
DR PANTHER; PTHR12840; NADH-UBIQUINONE OXIDOREDUCTASE ASHI SUBUNIT; 1.
DR Pfam; PF05821; NDUF_B8; 1.
DR PIRSF; PIRSF009288; NDUB8; 1.
PE 3: Inferred from homology;
KW Electron transport {ECO:0000256|PIRNR:PIRNR009288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR009288};
KW Mitochondrion {ECO:0000256|PIRNR:PIRNR009288};
KW Mitochondrion inner membrane {ECO:0000256|PIRNR:PIRNR009288};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Respiratory chain {ECO:0000256|PIRNR:PIRNR009288};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR009288}.
FT TRANSMEM 124..146
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 186 AA; 21897 MW; BFAB4748BC55C3C2 CRC64;
MAAARAWVLG VRRLQRATRT VMPLGARTAS HITKDMLPGP YPKTPEERAA AAKKYNMRVE
DYEPYPDDGM GYGDYPKLPD RSQQERDPWY NWDHSDLRLN WGEPMHWDLD MYIRNRVDTS
PTPVSWNLMC KHLFGFVAFM LFMFWVGETY RTYQPVGPKQ YPYNNLYLER GGDPTKEPEP
VVHYEI
//
