ID   A0A3Q7S169_VULVU        Unreviewed;       512 AA.
AC   A0A3Q7S169;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Acid-sensing ion channel 2 isoform X1 {ECO:0000313|RefSeq:XP_025851934.1};
GN   Name=ASIC2 {ECO:0000313|RefSeq:XP_025851934.1};
OS   Vulpes vulpes (Red fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX   NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025851934.1};
RN   [1]
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (JAN-2019) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_025851934.1}
RP   IDENTIFICATION.
RC   STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025851934.1};
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_025851934.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   RefSeq; XP_025851934.1; XM_025996149.1.
DR   AlphaFoldDB; A0A3Q7S169; -.
DR   STRING; 9627.ENSVVUP00000028108; -.
DR   KEGG; vvp:112918000; -.
DR   OrthoDB; 3415680at2759; -.
DR   Proteomes; UP000286640; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015280; F:ligand-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0050909; P:sensory perception of taste; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.3590.10; acid-sensing ion channel 1 domain; 2.
DR   Gene3D; 1.10.287.820; Acid-sensing ion channel domain; 1.
DR   Gene3D; 1.10.287.770; YojJ-like; 2.
DR   InterPro; IPR001873; ENaC.
DR   InterPro; IPR004724; ENaC_chordates.
DR   InterPro; IPR020903; ENaC_CS.
DR   NCBIfam; TIGR00859; ENaC; 1.
DR   PANTHER; PTHR11690:SF128; ACID-SENSING ION CHANNEL 2; 1.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
DR   PROSITE; PS01206; ASC; 1.
PE   4: Predicted;
KW   Ion channel {ECO:0000256|ARBA:ARBA00022461};
KW   Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW   Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW   Taste {ECO:0000256|ARBA:ARBA00022480};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|ARBA:ARBA00022461}.
SQ   SEQUENCE   512 AA;  57668 MW;  C1C9A6EDD380E40B CRC64;
     MDLKESPSEG SLQPSSIHIF ANTSTLHGIR HIFVYGPMTI RRVLWAVAFV GSLGLLLVES
     SERVSYYLSY QHVTKVDEVV AQSLVFPAVT LCNLNGFRFS RLTTNDLYHA GELLALLDVN
     LQIPDPHLAD PTVLEALRQK ANFKHYKPKQ FSMLEFLHRV GHDLKDMLLY CKFKGQECGH
     QDFTTVFTKY GKCYMFNSGE DGKPLLTTVK GGTGNGLEIM LDIQQDEYLP IWGETEETTF
     EAGVKVQIHS QSEPPFIQEL GFGVAPGFQT FVATQEQRLT YLPPPWGECR SSEMGLDFFP
     VYSITACRID CETRYIVENC NCRMVHMPGD APFCTPEQHK ECAEPALGLL AEKDSNYCLC
     RTPCNLTRYN KELSMVKIPS KTSAKYLEKK FNKSEKYISE NILVLDIFFE ALNYETIEQK
     KAYEVAALLG DIGGQMGLFI GASILTILEL FDYIYELIKE KLLDLLGKEE DEGSHDENVS
     TCDTMPNHSE TISHTVNVPL QTALGTLEEI AC
//