ID A0A3Q7S2X4_VULVU Unreviewed; 1553 AA.
AC A0A3Q7S2X4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=DENN domain-containing protein 4B isoform X2 {ECO:0000313|RefSeq:XP_025852894.1};
GN Name=DENND4B {ECO:0000313|RefSeq:XP_025852894.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025852894.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025852894.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025852894.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025852894.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_025852894.1; XM_025997109.1.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.100.10.50; -; 1.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR023341; MABP.
DR InterPro; IPR002885; Pentatricopeptide_rpt.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR NCBIfam; TIGR00756; PPR; 1.
DR PANTHER; PTHR12296; DENN DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR12296:SF18; DENN DOMAIN-CONTAINING PROTEIN 4B; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS51498; MABP; 1.
DR PROSITE; PS51375; PPR; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640}.
FT DOMAIN 55..214
FT /note="MABP"
FT /evidence="ECO:0000259|PROSITE:PS51498"
FT DOMAIN 257..704
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REPEAT 872..906
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT REGION 34..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 778..803
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 951..1027
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1046..1203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1258..1286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..55
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 956..1006
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1127..1145
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1160..1203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1553 AA; 170105 MW; F5114E7820EBE07E CRC64;
MAADAVSEGG AMAEERPPRL VDYFVIAGLA GNGAPIPEET RVPEPSGPLR PPRPAEPITD
MAVIARALGE EVPQGYTCIQ SSAGGHPLEL SAGLLGGTQP VICYRRGRDK PPLVELGVLY
EGKERPKPGF QVLDTTPYSH SANLAPPGPG HPRTYLTCRR AAEGAGLHAL GITDVCLVLP
SKGEGTPHTY CRLPRNLNPG VWGPAVYLCY KVGLAKAHTL VYEAGEWPPC ASRPLLLRVP
PALVPIGWQH RHAQNSLLLC HLAFLWHLLG PPTELLGRYP EEDNEAFPLP ESVPVFCLPM
GATVECWPAH TKYPVPVFST FVLTGAAGDK VYGAALQFYE AFPRARLSER QARALGLLSA
VERGRALGGR AVRSRRAIAV LSRWPAFPAF RAFLTFLYRY SVSGPHRLPL EAHISHFIHN
VPFPSPQRPR ILVQMSPYDN LLLCQPVSSP LPLSGASFLQ LLQSLGPELA ITLLLAVLTE
HKLLVHSLRP DLLTSVCEAL VSMIFPLHWQ CPYIPLCPLV LADVLSAPVP FIVGIHSSYF
DLHDPPADVI CVDLDTNTLF QTEEKKPLSP RTLPRRPYKV LLATLTNLYQ QLDQTYTGPE
EEASLEFLLT DYEAVCGRRA RLEREVQGAF LRFMACLLKG YRDFLRPLTQ APSEGVRDVD
NLFFLQGFLK SRERSSHKLY CQLLRTQMFS QFIEECSFGS ARHAALEFFD SCVDKVHPEQ
EKPEPTPLVE LEELSGSELT VFITPPEEPA APEGSDSTPQ YCYDGFPELR AELFESPHEQ
PGALPVPGPS RSAPSSPAPR RTKQEMKVAQ RMAQKSAAVP ELWARCLLGH CYGLWFLCLP
AYVRSAPSRV QALHTAYQVL RQMESRKVVL PDEVCYRVLM QLCSHYGQPV LSVRVMLEMR
RAGIVPNTIT YGYYNKAVLE SKWLSGTPGG RLRWAKLRNV VLGAAQFRQP LRERRRQQQQ
QQQQQQQQQQ AAAQEAGSSQ TEPYLERHSP TRPLQRQTTW AGQSFRDPAS PTGRLVKSGS
LGSARGAQPT VEAGVAHKAL GVLEPRGSPV PWHDGSLSDL SLTGEELAPG GSLEDSGSAL
GAQSTEALEG PSGLASKASG RQDEASTPRR GLGARLQQLL TPSRRSPASH VPPPELPPDL
PPPARRSPMD SLLRPRERPG STASESSASL GSEWDLSESS ASSLSLRRSS ERLSDTPGSS
QPPSLEILLS SCSSCRACDS LVYDEEIMAG WAPDDSNLNT ICPFCACPFV PLLSVQTLDS
RPSAPSPKPA PAGASNSKDA PTPGGSGPVL SDRRLCLALD EPQLCNGHMG AVPRRVEGGA
WAYLSPLVLR KELESLVENE GSEVLALPEL PAAHPIIFWN LLWYFQRLRL PNILPCLVLA
SCDGPPLPQA PSPWLMPDPA SVQVRLLWDV LTPDPSSCPP LYVLWRIHSQ IPQRVVWPGP
IPAPLSLDLL ESVLRHVGLN EVHKAVGLLL ETLGPPPAGL HLQRGIYREI LFLTMAALGK
DHVDIVAFDK KYKSAFNKLA SSMGKEELRQ RRAQMPSPKA IDCRKCFGAP LEC
//
