ID   A0A3Q7S4D1_VULVU        Unreviewed;       619 AA.
AC   A0A3Q7S4D1;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=NEDD8 ultimate buster 1 {ECO:0000313|RefSeq:XP_025849556.1};
GN   Name=NUB1 {ECO:0000313|RefSeq:XP_025849556.1};
OS   Vulpes vulpes (Red fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX   NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025849556.1};
RN   [1]
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (JAN-2019) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_025849556.1}
RP   IDENTIFICATION.
RC   STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025849556.1};
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_025849556.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_025849556.1; XM_025993771.1.
DR   AlphaFoldDB; A0A3Q7S4D1; -.
DR   STRING; 9627.ENSVVUP00000010214; -.
DR   Ensembl; ENSVVUT00000013359; ENSVVUP00000010214; ENSVVUG00000007531.
DR   KEGG; vvp:112916204; -.
DR   OMA; SAQAKYM; -.
DR   OrthoDB; 2916923at2759; -.
DR   Proteomes; UP000286640; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:Ensembl.
DR   GO; GO:0034612; P:response to tumor necrosis factor; IEA:Ensembl.
DR   GO; GO:0034341; P:response to type II interferon; IEA:Ensembl.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR   CDD; cd14291; UBA1_NUB1_like; 1.
DR   CDD; cd14292; UBA2_NUB1; 1.
DR   CDD; cd14293; UBA3_NUB1; 1.
DR   CDD; cd17062; Ubl_NUB1; 1.
DR   Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 3.
DR   InterPro; IPR039749; NUB1.
DR   InterPro; IPR041207; NUB1_ubiquitin-like_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR015940; UBA.
DR   InterPro; IPR009060; UBA-like_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR12948:SF3; NEDD8 ULTIMATE BUSTER 1; 1.
DR   PANTHER; PTHR12948; NEDD8 ULTIMATE BUSTER-1 BS4 PROTEIN; 1.
DR   Pfam; PF00627; UBA; 3.
DR   Pfam; PF18037; Ubiquitin_5; 1.
DR   SMART; SM00165; UBA; 3.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   SUPFAM; SSF46934; UBA-like; 3.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50030; UBA; 3.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000286640}.
FT   DOMAIN          373..413
FT                   /note="UBA"
FT                   /evidence="ECO:0000259|PROSITE:PS50030"
FT   DOMAIN          423..469
FT                   /note="UBA"
FT                   /evidence="ECO:0000259|PROSITE:PS50030"
FT   DOMAIN          488..528
FT                   /note="UBA"
FT                   /evidence="ECO:0000259|PROSITE:PS50030"
FT   REGION          531..587
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          407..435
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        538..565
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        566..587
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   619 AA;  70992 MW;  059DD14DEF6D77C5 CRC64;
     MAQKKYLQAK LTQFLREDRI QLWKPPYTDE NKEVGLALKD LAKKYSDRLE CCENEVEKII
     EEIRCKAIKR GTGNENYKTT GIATIEVFLP PRLRKDRKNL LETRLHITGR ELRSKIAETF
     GFQENYIKIV INKKQLQLGK TLEEQGVTHN VKAMVLELKQ SEEDVRKNFQ LEEEEQNEAE
     LKERRIQRTK RGLEILAERA EMVVDPETTP YLDIANQTGR SIRIPPSERK ALMLAMGYHE
     KGRAFLKRKE YGIALPCLLD ADKYFCECCR ELLDTVDNYA VLQLDIVWCY FCLEQLECLD
     DAEKKLNLAQ KCFKNCYGEN HQRLVNIKGN CGKEKVLFLR LYLLQGIRNY HSGNGEEARE
     YLNKARQLFK ELYIDPSKVH NLLQLGFTAQ EARLGLRACD GNVDHAAAHI TNRREELAQI
     RKEEKEKKRR RLENINSLKG MGYSTHAAKQ ALHQASGNLD EALKILLSNP QMWWLNDSDP
     ETNNQQESPS QENIDQLVYM GFDAVVADAA LRVFRGNVQL AAQTLAHNGG TLPPDLQLLV
     EDSSSTPSTS PSDSAGTSSA STDEDMETEA VNEILEDIPE HEEDYLDSTL EDEEIIIAEY
     LSYVENIKSA TKKNNNEQK
//