ID A0A3Q7S4P7_VULVU Unreviewed; 1108 AA.
AC A0A3Q7S4P7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=DNA mismatch repair protein Msh3 {ECO:0000313|RefSeq:XP_025853824.1};
GN Name=MSH3 {ECO:0000313|RefSeq:XP_025853824.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025853824.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025853824.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025853824.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025853824.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MSH3
CC subfamily. {ECO:0000256|ARBA:ARBA00007094}.
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DR RefSeq; XP_025853824.1; XM_025998039.1.
DR AlphaFoldDB; A0A3Q7S4P7; -.
DR STRING; 9627.ENSVVUP00000034564; -.
DR KEGG; vvp:112919583; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF122; DNA MISMATCH REPAIR PROTEIN MSH3; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF00488; MutS_V; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640}.
FT DOMAIN 943..959
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 155..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 685..712
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 167..188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1108 AA; 125337 MW; B326CF64A50EA4F9 CRC64;
MHLLTSSLPL GTFKKNVDWR LKGSFAYLLY ICFARTVVSK PPVFSMPQRC SVAEVGSSKK
RPLESDGTVQ KKAKKVQGKE GRSDLVISGN SEPKKCLRTK TVLKSLEKLK QFCCASALAQ
NRVQTVPLQE RFAVLPKCTD FDDITHLRAK NVISSEDSKS HINQKDKTLS DLSPFGSSCT
GNDDLQKTPD PKPSNKRTKS IYTPLELQYI ELKQQQKDAI LCVECGYKYR FFGEDAEIAA
RELNIYCHLD HNFMTASIPT HRLFVHVRRL VAKGYKVGVV KQTETAALKA VGDNKSSLFS
RKLTALYTKS TLIGEDVNPL VKLDDAINVD EVMTDTTTSF LLCICENEEN VKDKKKGNIF
IGIVGVQPVT GEVVFDSFQD SASRSELETR ILCLQPVEML LPSRLSEQTE TLVHRATAAS
VRDDRIRVER MDNIYFEYSH AFQAVTEFYA EDAVDIQASQ SFSGIINLDK PVICSLAAVI
RYLKEFNLEK VLSKPKNFKQ FSGEMEFMTI NGTTLRNLEI LQNQTDMKTK GSLLWVLDHT
KTSFGRRKLK KWVVQPLLKL REINARLDAV SEVLHSESSV FGQIENHLRK LPDIERGLCS
IYHKKCSTQE FFLIVKTLYH LKSEFQALIP AVNSHVQSDL LRTFILEIPE LLSPVEHYLR
ILNEQAAKIG DKTELFKDLT DFPLIKKRKD EIQEITDNIQ VHLQEIRKIL KNPSLQYVTV
SGQEFMIEIK NSAVSCIPTD WVKVGSTKAV SRFHSPFIVE NYRHLNQLRE QLVLDCSAEW
LDFLENFSAH YHSLCKAVHH LATVDCIFSL AKVAKQGDYC RPSLQEERKI VIKNGRHPVI
DVLLGEQDQY VPNSTNLSGD SERVMIITGP NMGGKSSYIK QVALITIMAQ IGSYVPAEEA
TIGIVDGIFT RMGAADNIYK GQSTFMEELM DTAEIIRQAT SQSLVILDEL GRGTSTYDGI
AIAYATLEHF IRDVKSLTLF VTHYPPVCEL EKSYLQEVGN YHMGFLVNED ENKEDPGEEP
VPDFVTFLYQ ITRGIAARSY GLNVAKLADV PGEILKKAAS KSKELEGLVN MKRKRLKCFT
KLWMISDAKD LQRWTDEFEM EEISDFSS
//