ID A0A3Q7S4U9_VULVU Unreviewed; 923 AA.
AC A0A3Q7S4U9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN Name=OSBPL6 {ECO:0000313|RefSeq:XP_025849746.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025849746.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025849746.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025849746.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025849746.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the OSBP family.
CC {ECO:0000256|RuleBase:RU003844}.
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DR RefSeq; XP_025849746.1; XM_025993961.1.
DR AlphaFoldDB; A0A3Q7S4U9; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd13287; PH_ORP3_ORP6_ORP7; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041680; PH_8.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10972:SF76; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 6; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF15409; PH_8; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|RuleBase:RU003845};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT DOMAIN 86..181
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 923 AA; 104772 MW; FB84A2E673D76920 CRC64;
MSSDEKGISP AHKTSTPTHR SASSSTSSHR ESRQSIHVLE RTASSSTEPS VSRQLLEPEP
VPLSKEADSW EIIEGLKIGQ TNVQRPDKHE GFMLKKRKWP LKGWHKRFFV LDNGMLKYSK
APLDIQKGKV HGSIDVGLSV MSIKKKARRI DLDTEEHIYH LKVKSQDWFD AWVSKLRHHR
LYRQNEIVRS PRDASFHIFP STSTAESSPA ANVSVVDGKV PPNSFPWQSP LPCSNSLPAT
CTTGQSKVAA WLQDSEEMDR CAEDLAHCQS NLVELSKLLQ NLEILQRTQS APNFTDMQAN
CVDISKKDKR VTRRWRTKSV SKDTKIQLQE GPAAKGQFST ARRRQRLAAA VATTVPFSAT
MSPVRLHSSN PNLCADIEFQ TPPSHLTDPL ESSTDYTKLQ EEFCLIAQKV HSLLKSAFNS
IAIEKEKLKQ MVSEQDHNKG HSTQMARLRQ SLSQAGEQIH VSLPLSQQVA NESRLSMSES
VSEFFDAQEV LLSASSSENE ASDDESYISD VSDNISEDNT SVADNISRQI LNGELTGGAF
RNGRRTCLPA PCPDTSNINL WNILRNNIGK DLSKVSMPVE LNEPLNTLQH LCEEIEYSEL
LDKASETDDP YERMVLIAAF AVSGYCSTYF RAGSKPFNPV LGETYECIRE DKGFRFFSEQ
VSHHPPISAC HCESKNFVFW QDIRWKNKFW GKSMEILPVG TLNVMLPKYG DCYVWNKVTT
CIHNILSGRR WIEHYGEVTI RNTKSSVCIC KLTFVKVNYW NSNVNEVQGV VMDQEGKVVH
RLFGKWHEGL YCGVAPSAKC IWRPGSMPTN YELYYGFTRF AIELNELDPV LKDLLPSTDA
RFRPDQRFLE EGNLEAAAAE KQRVEELQRS RRRYMEENNL EHIPKFFKKV VDANQREAWV
SNDTYWELRK DPGFSKVDSP VLW
//
