ID   A0A3Q7S525_VULVU        Unreviewed;       632 AA.
AC   A0A3Q7S525;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Cytoplasmic dynein 1 intermediate chain 2 {ECO:0000256|ARBA:ARBA00040292};
DE   AltName: Full=Cytoplasmic dynein intermediate chain 2 {ECO:0000256|ARBA:ARBA00042023};
DE   AltName: Full=Dynein intermediate chain 2, cytosolic {ECO:0000256|ARBA:ARBA00042966};
GN   Name=DYNC1I2 {ECO:0000313|RefSeq:XP_025849831.1,
GN   ECO:0000313|RefSeq:XP_025849832.1};
OS   Vulpes vulpes (Red fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX   NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025849831.1};
RN   [1]
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (JAN-2019) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_025849831.1, ECO:0000313|RefSeq:XP_025849832.1}
RP   IDENTIFICATION.
RC   STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025849831.1,
RC   ECO:0000313|RefSeq:XP_025849832.1};
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_025849831.1,
RC   ECO:0000313|RefSeq:XP_025849832.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the dynein intermediate chain family.
CC       {ECO:0000256|ARBA:ARBA00011059}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_025849831.1; XM_025994046.1.
DR   RefSeq; XP_025849832.1; XM_025994047.1.
DR   STRING; 9627.ENSVVUP00000021264; -.
DR   Ensembl; ENSVVUT00000028213; ENSVVUP00000021264; ENSVVUG00000015635.
DR   Proteomes; UP000286640; Unplaced.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005868; C:cytoplasmic dynein complex; IEA:InterPro.
DR   GO; GO:0005874; C:microtubule; IEA:Ensembl.
DR   GO; GO:0031982; C:vesicle; IEA:Ensembl.
DR   GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR025956; DYNC1I1/DYNC1I2.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR12442:SF37; CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN 2; 1.
DR   PANTHER; PTHR12442; DYNEIN INTERMEDIATE CHAIN; 1.
DR   Pfam; PF11540; Dynein_IC2; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
PE   3: Inferred from homology;
KW   Dynein {ECO:0000256|ARBA:ARBA00023017};
KW   Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW   Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT   REGION          1..129
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          151..208
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..62
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        85..102
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        174..208
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   632 AA;  70705 MW;  F74299B1BE8333D3 CRC64;
     MSDKSELKAE LERKKQRLAQ IREEKKRKEE ERKKKETDQK KEAVAPVQEE SDLEKKRREA
     EALLQSMGLT PESPIVPPPM SPSSKSVSTP SEAGSQDSGD GAVGSRTLHW DTDPSVLQLH
     SDSDLGRGPI KLGMAKITQV DFPPREIVTY TKETQTPVMA QPKEDEEEED DVVTPKPPIE
     PEEEKTLKKD EENDSKAPPH ELTEEEKQQI LHSEEFLSFF DHSTRIVERA LSEQINIFFD
     YSGRDLEDKE GEIQAGAKLS LNRQFFDERW SKHRVVSCLD WSSQYPELLV ASYNNNEDAP
     HEPDGVALVW NMKYKKTTPE YVFHCQSAVM SATFAKFHPN LVVGGTYSGQ IVLWDNRSNK
     RTPVQRTPLS AAAHTHPVYC VNVVGTQNAH NLISISTDGK ICSWSLDMLS HPQDSMELVH
     KQSKAVAVTS MSFPVGDVNN FVVGSEEGSV YTACRHGSKA GISEMFEGHQ GPITGIHCHA
     AVGAVDFSHL FVTSSFDWTV KLWTTKNNKP LYSFEDNSDY VYDVMWSPTH PALFACVDGM
     GRLDLWNLNN DTEVPTASIS VEGNPALNRV RWTHSGREIA VGDSEGQIVI YDVGEQIAVP
     RNDEWARFGR TLAEINANRA DAEEEAATRI PA
//