ID A0A3Q7S811_VULVU Unreviewed; 572 AA.
AC A0A3Q7S811;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Mothers against decapentaplegic homolog {ECO:0000256|RuleBase:RU361195};
DE Short=MAD homolog {ECO:0000256|RuleBase:RU361195};
DE Short=Mothers against DPP homolog {ECO:0000256|RuleBase:RU361195};
DE AltName: Full=SMAD family member {ECO:0000256|RuleBase:RU361195};
GN Name=SMAD6 {ECO:0000313|RefSeq:XP_025851001.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025851001.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025851001.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025851001.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025851001.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU361195}.
CC Nucleus {ECO:0000256|RuleBase:RU361195}.
CC -!- SIMILARITY: Belongs to the dwarfin/SMAD family.
CC {ECO:0000256|ARBA:ARBA00005545, ECO:0000256|RuleBase:RU361195}.
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DR RefSeq; XP_025851001.1; XM_025995216.1.
DR AlphaFoldDB; A0A3Q7S811; -.
DR KEGG; vvp:112917280; -.
DR OrthoDB; 2916296at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd10493; MH1_SMAD_6; 1.
DR CDD; cd10499; MH2_SMAD_6; 1.
DR Gene3D; 2.60.200.10; -; 1.
DR Gene3D; 3.90.520.10; SMAD MH1 domain; 1.
DR InterPro; IPR013790; Dwarfin.
DR InterPro; IPR003619; MAD_homology1_Dwarfin-type.
DR InterPro; IPR013019; MAD_homology_MH1.
DR InterPro; IPR017855; SMAD-like_dom_sf.
DR InterPro; IPR001132; SMAD_dom_Dwarfin-type.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR036578; SMAD_MH1_sf.
DR PANTHER; PTHR13703:SF28; MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 6; 1.
DR PANTHER; PTHR13703; SMAD; 1.
DR Pfam; PF03165; MH1; 1.
DR Pfam; PF03166; MH2; 1.
DR SMART; SM00523; DWA; 1.
DR SMART; SM00524; DWB; 1.
DR SUPFAM; SSF56366; SMAD MH1 domain; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS51075; MH1; 1.
DR PROSITE; PS51076; MH2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU361195};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU361195};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU361195};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU361195}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 204..349
FT /note="MH1"
FT /evidence="ECO:0000259|PROSITE:PS51075"
FT DOMAIN 405..572
FT /note="MH2"
FT /evidence="ECO:0000259|PROSITE:PS51076"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 108..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 215..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 572 AA; 61564 MW; 15E69E015BBACFDD CRC64;
MVAAIPSQTS NYPGSSRSSE ERRAGIVIFS NKKLTAILIR PEQLEGGGEE ASRPGLPFMS
TTQRAQHLAA GSKKEAEGIN KPAFRLLQEE PMLAGPCRVF PGRGAACSPP SSAGAGVAEQ
PGRRGPCSRW PSADCGSARA RPPPSRPGEL PHVAALRRPF DDRLCATCTA PGGGASCGAA
ARAAGASLTE RTTGYRMFRS KRSGLVRRLW RSRVVPDREE GGGGGGGGGG GEDGTRSRLL
LLEQELKTVT YSLLKRLKER SLDTLLEAVE SRGGVPGGCV LVPRADLRLG GQPAPPQLLL
GRLFRWPDLQ HAVELKPLCG CHSFAAAADG PTVCCNPYHF SRLCGPESPP PPYSRLSPRD
EYKPLDLSDS TLSYTETEAT NSLITAPGEF SDASMSPDAT KPSHWCSVAY WEHRTRVGRL
YAVYDQAVSI FYDLPQGSGF CLGQLNLEPR SESVRRTRSK IGFGILLSKE PDGVWAYNRG
EHPIFVNSPT LDAPGGGRAL VVRKVPPGYS IKVFDFERSG LLQQGPEPDA ADGPYDPNSV
RISFAKGWGP CYSRQFITSC PCWLEVLLNN HR
//
