ID A0A3Q7SBE7_VULVU Unreviewed; 652 AA.
AC A0A3Q7SBE7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPN18 {ECO:0000313|RefSeq:XP_025852366.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025852366.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025852366.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025852366.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025852366.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class 4 subfamily. {ECO:0000256|ARBA:ARBA00034734}.
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DR RefSeq; XP_025852366.1; XM_025996581.1.
DR KEGG; vvp:112918511; -.
DR OrthoDB; 5489271at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0004726; F:non-membrane spanning protein tyrosine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR047170; PTN12/18/22.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR45983; TYROSINE PHOSPHATSE N18, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR45983:SF4; TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 18; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640}.
FT DOMAIN 299..526
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 453..530
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 1..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 607..652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..151
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 652 AA; 70213 MW; B1679660480A29C7 CRC64;
MLLTVRQTPA YEKAPLSTTQ KKEPQEIQEN RASSRPFSQA AEPGCQLRPR RPPAPRLGPA
AALSARGAPT PGASGRAAAA TLAGSPADRS RTLDPGGQAR MHGHLPSAGP VGGGGPRERI
LPGMVWGGSR GSSGLNPHAR RPERGKHLRW TQFSRPEGGC GRRPPGPEPQ GGARPSRPAR
PGGFARFHRV PRSEAGPAVR APRAPAARDP AGRSRWPGPR RPAEPGAARP HAILRVCTHF
SQARYLVSLQ VLLSPRTLTW PPSSSLLLPL GSAHGDFLQD ILAGSAAWKT EGVCSTEVGN
LPGNVRKNHY KDVLLYDQTQ VILSLLQEEG HGDYINGNFI RGTDGSQAYI ATQGLLPHNM
LDFWRLVWEF GVKVILMACP EMENGQKKCE HFWAREREPL QIGLFCITLT RETRLNTDIV
LRTLQVTFQK KCPSVYQLQY MSWPDRGVPS SPEYVLTMVE EARRLQGSGP SPLCVHCSVG
CGXTGVLCTV DYVRQLLLTQ MIPPNFSLFN VVLEMRNQRP AAVQTEVRGS VSSIQGHIPP
PLVFPHCAPV YEDALSFQTS LALTTTPRPV GEVLSPAARD GAPSVCQGSV GLSRSVGAGV
VVLPTAPADQ SPAGPDAYED VVDGPQTGGL GFNLRIGRPK GPREPPADWS QV
//
