ID   A0A3Q7SBK2_VULVU        Unreviewed;       825 AA.
AC   A0A3Q7SBK2;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Intraflagellar transport protein 88 homolog isoform X1 {ECO:0000313|RefSeq:XP_025852426.1};
GN   Name=IFT88 {ECO:0000313|RefSeq:XP_025852426.1};
OS   Vulpes vulpes (Red fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX   NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025852426.1};
RN   [1]
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (JAN-2019) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_025852426.1}
RP   IDENTIFICATION.
RC   STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025852426.1};
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_025852426.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_025852426.1; XM_025996641.1.
DR   AlphaFoldDB; A0A3Q7SBK2; -.
DR   STRING; 9627.ENSVVUP00000008743; -.
DR   Ensembl; ENSVVUT00000011525; ENSVVUP00000008743; ENSVVUG00000006528.
DR   KEGG; vvp:112918598; -.
DR   OrthoDB; 312444at2759; -.
DR   Proteomes; UP000286640; Unplaced.
DR   GO; GO:0005814; C:centriole; IEA:Ensembl.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR   GO; GO:0030992; C:intraciliary transport particle B; IEA:Ensembl.
DR   GO; GO:0045724; P:positive regulation of cilium assembly; IEA:Ensembl.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR44117; INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG; 1.
DR   PANTHER; PTHR44117:SF1; INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG; 1.
DR   Pfam; PF12895; ANAPC3; 1.
DR   Pfam; PF13424; TPR_12; 1.
DR   Pfam; PF13174; TPR_6; 1.
DR   Pfam; PF13181; TPR_8; 1.
DR   SMART; SM00028; TPR; 11.
DR   SUPFAM; SSF81901; HCP-like; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50005; TPR; 7.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT   REPEAT          233..266
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          272..305
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          485..518
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          519..552
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          553..586
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          587..620
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          621..654
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          112..136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          725..825
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        725..739
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        741..760
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   825 AA;  93333 MW;  C0D0F3D6868EC9A5 CRC64;
     MMQNVHLAPE TDEDDLYSGY NDYNPTYDTE ELENDTAFQQ AVRTSHGRRP PITAKIPSTA
     VTRPVATGYG SKTSLASSMG RPMTGAIQDG VTRPMTAVRA AGFTKAALRG SAFDPLGQSR
     GPAPPLEAKN EDSPEEKIRQ LEKKVNELVE ESCIANSCGD LKLALEKAKD AGRKERILVR
     QREQVTTPEN INLDLTYSVL LNLASQYSAN EMYAEALNTF QVIVKNKMFS NAGRLKVNMG
     NIYLKQRNYS KAIKFYRMAL DQIPSVHKEM RIKIMQNIGV TFIKTGQYSD AINSFEHIMS
     MAPNLKAGFN LILSYFAVGD RDKMKKAFQK LIAVPLEIDE DDKYISPSDD PHTNLVIEAI
     KNDHLRQMER ERKAMAEKYI MTAAKLIAPV IETSFAVGYD WCVEVVKASQ YVELANDLEI
     NKAITYLRQK DFNQAVETLK MFEKKDSRVK SAAATNLSFL YFLENEFAQA SSYADLAVNS
     DRYNPSALTN KGNTVFANGD YEKAAEFYKE ALRNDSSCTE ALYNIGLTYK RLNRLDEALD
     CFLKLHAILR NSAQVLYQIA NVYELMEDPN QAIEWLMQLI SVVPTDSRAL SKLGELYDSE
     GDKSQAFQYY YESYRYFPSN IEVIEWLGAY YIDTQFCEKA IQYFERASLI QPTQVKWQLM
     VASCFRRSGN YQKALDTYKD IHRKFPENVE CLRFLVRLCT DIGLKEVQEY ATKLKRLEKM
     KEIREQRIKS GRDGSGGPRS RREGSASSDS GQNCSASSKG ERLSAKLRAL PGTNEPYESS
     SNKEIDASYV DPLGPQIERP KTAAKKRIDE DDFADEELGD DLLPE
//