ID A0A3Q7SCA2_VULVU Unreviewed; 941 AA.
AC A0A3Q7SCA2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Integrin alpha-7 isoform X7 {ECO:0000313|RefSeq:XP_025857799.1};
GN Name=ITGA7 {ECO:0000313|RefSeq:XP_025857799.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025857799.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025857799.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025857799.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025857799.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR RefSeq; XP_025857799.1; XM_026002014.1.
DR AlphaFoldDB; A0A3Q7SCA2; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF90; INTEGRIN ALPHA-7; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 4.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 3.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 842..864
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 110..171
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 172..227
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 231..290
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 275..439
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 441..604
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 611..829
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
FT REGION 711..738
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 896..941
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 711..733
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 941 AA; 102250 MW; B1F10ACFCCCC7658 CRC64;
MSGSTSPLCG PPSGCPVLGV SPHPPPAGLL FVTNIDSSDP DQLVYKTLDP ADRLPGPAGD
LALNSYLGFS IDSGKGLVRA EELSFVAGAP RANHKGAVVI LRKDSASRLV PEVMLSGERL
TSGFGYSLAV ADLNNDGWTD LVVGAPYFFE RQEELGGAVY VYLNQGGHWA GVSPLRLCGS
PDSMFGISLA VLGDLNQDGF ADIAVGAPFD GDGKVFIYHG SSLGVVVKPS QVLEGEAVGV
KSFGYSLSGG LDVDGNHYPD LLVGSLADTA VLFRARPVLQ VSHEVFIAPR AIDLEQPNCA
AGHLVCVDLR VCFSYIATPS SYSPIVALDY VLDGDTDRRL RGQIPRVTFL SRGPDDPKHQ
SSGTVWLKHQ HDRVCGDTMF QLQENVKDKL RAIVVTLSYN LQTPRLRRQA PGQGLPAVTP
ILNAHQSSTQ RAEIHFLKQG CGEDKVCQSN LQLVRARFCA RVSDSEFQPL PMDADGTTAL
FALSGQPVIG LELTVTNLPS DPAQPQADGD DAHEAQLLVT LPASLHYSGV RALDPAEKPL
CVSNENASHV ECELGNPMKR GAQVTFYLIL STSGITIETT ELEVELLLAT ISEQELHPIS
VRARVFIELP LSIAGVAVPQ QLFFSGVVRG ESAMKSERDI GSKVKYEVTV SNQGQSLNTL
GSAFLNIMWP HEIANGKWLL YPMRVELEGG QGPRRKGLCS PRPNILHLDV DSRDRRRREL
EQPKQEEHPE HLEPSTSWWP VSSAEKKKNI TLDCARGTAN CVVFSCPLYS FDRAAVLHVW
GRLWNSTFLE EYSAVKSLEV TVRANITMKS SIKNLVLRDA STVIPVMVYL DPVAVVAEGV
PWWVILLAVL AGLLVLALLV LLMWKMGFFK RARYPEATVP QYHAVKIPRE DRQQFKEEKT
GTILRNNWGS PRREGPDAHP ILAADGHPEP GSDGHPMSST A
//
