ID   A0A3Q7SF61_VULVU        Unreviewed;       995 AA.
AC   A0A3Q7SF61;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Lysine-specific demethylase PHF2 isoform X3 {ECO:0000313|RefSeq:XP_025840270.1};
GN   Name=PHF2 {ECO:0000313|RefSeq:XP_025840270.1};
OS   Vulpes vulpes (Red fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX   NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025840270.1};
RN   [1]
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (JAN-2019) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_025840270.1}
RP   IDENTIFICATION.
RC   STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025840270.1};
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_025840270.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_025840270.1; XM_025984485.1.
DR   AlphaFoldDB; A0A3Q7SF61; -.
DR   Proteomes; UP000286640; Unplaced.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.58.1360; -; 1.
DR   Gene3D; 2.60.120.650; Cupin; 1.
DR   InterPro; IPR041070; JHD.
DR   InterPro; IPR003347; JmjC_dom.
DR   PANTHER; PTHR23123:SF14; LYSINE-SPECIFIC DEMETHYLASE PHF2; 1.
DR   PANTHER; PTHR23123; PHD/F-BOX CONTAINING PROTEIN; 1.
DR   Pfam; PF17811; JHD; 1.
DR   Pfam; PF02373; JmjC; 1.
DR   SMART; SM00558; JmjC; 1.
DR   SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR   PROSITE; PS51184; JMJC; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          80..236
FT                   /note="JmjC"
FT                   /evidence="ECO:0000259|PROSITE:PS51184"
FT   REGION          326..427
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          439..498
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          529..555
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          589..643
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          658..677
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          699..743
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          758..982
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        384..399
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        466..498
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        607..635
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        729..743
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        766..783
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        840..915
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        952..966
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   995 AA;  108806 MW;  DA5FEE2CEB3B5117 CRC64;
     MEEHGFAEPI LVPKKDGLGL AVPAPTFYVS DVENYVGPER SVDVTDVAKQ KDCKMKLKEF
     VDYYYSTNRK RVLNLTSLEF SDTRMSSFVE PPDIVKKLSW VENCWPDDAL LAKPKVTKYC
     LICVKDSYTD FHIDSGGASA WYHVLKGEKI FYLIKPASAN ISLYERWQSA ANHSEMFFAD
     QVDRCYKCTV KQGQTLFIPS GWIYATLTPV DCLAFAGHFL HSLSVEMQMR AYEVERRLKL
     GSLTQFPNFE TACWYMGKHL LEAFRGSHKS GKQLPPHLVQ GAKILNGAFR SWTKKQALAE
     HEDELPEHFK PSQLIKDLAK EIRLSENASK AARPEVTPAV PTDEVCFGDR EKEEPPSPIE
     ASPPRSFLEK VSKKKIPKTV KMPKPSKVPK PPKPPKPPKS PKPLKLKDGG KKKGKKCRGA
     ASPTIPNLDL LEAHTKEALT KIEPPKKGKA TKSVLSVPNK EAISSQNDVE RLEIREQTKS
     KSEAKWKYKN SKPDSLLKME EEQKLEKCPL SGNRDPKFSF SFNRRLLSPK ALKPQPSPGV
     FGAMQSFKED KPQPVRDEYE YVSDDGELKI DEFPIRRKRT APKRDLSFLL DGKEPLPTPV
     TKPKLESALY KSDDSSDEGS LHIDTDTKPA RNAKVKKEGA GSAAGILDLL QASEEVGALE
     YNPNSQPPAS PSTQEAIQGM LSMANLQASD SCLQTTWGAG QAKGSSLAAH GARKNGGGSK
     STGKRLLKRA AKNSMDLDDY EEEQDHLDAC FKDSDYVYPS LESDEDSPVF KSRSKRRKGS
     DDAPYSPTAR VGPSVPRQDR PVREGTRVAS IETGLAAAAA KLSQQEEQKS RKKKNTKRKL
     APNTPSPSAS TTSASTTSAS TTSASTTSAS TTSASTTSAS TTSASTTPAS TTPASTSTAS
     SQASQEGSSP EPPAEAHSSS LADHEYTAAG AFAGAQAGRA SQPMAPGVFL TQRRPSASSP
     NNTAAKGKRT KKGMATAKQR LGKILKIHRN GKLLL
//