ID A0A3Q7SFE9_VULVU Unreviewed; 2105 AA.
AC A0A3Q7SFE9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Dedicator of cytokinesis protein 9 isoform X23 {ECO:0000313|RefSeq:XP_025859464.1};
GN Name=DOCK9 {ECO:0000313|RefSeq:XP_025859464.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025859464.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025859464.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025859464.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025859464.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR RefSeq; XP_025859464.1; XM_026003679.1.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR CDD; cd11698; DHR2_DOCK9; 1.
DR CDD; cd13267; PH_DOCK-D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF77; DEDICATOR OF CYTOKINESIS PROTEIN 9; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640}.
FT DOMAIN 185..292
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 651..829
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1640..2067
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 301..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1253..1295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..317
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2105 AA; 240646 MW; 331893B7CB8115B2 CRC64;
MGCTTSVILF KGIRTVFERN CAYMCKQQGE NNALEYTAYH WTKEDSELLI SSCLAKPKLI
EPLDYENVIV QKKTQILNDC LREMLLFPYD DFQTATLRRQ GRYMCSTVPA DAEEEAQSLF
VTECIKTYNS DWHLVNYKFE DYSGEFRQLP NKVAKLDKLP VHVYEVDEEV DKDEDAASLG
SQKGGITKHG WLYKGNMNSA ISVTMRSFKR RFFHLLQLGD GSYNLNFYKD EKISKEPKGS
IFLDSCMGVV QNNKVRRFAF ELKMQDKSSY LLAADSEAEM EEWITILNKI LQLNFEAAMQ
EKRNGDSHED DEQSKFEGSG SGLDSYLPEL AKSTREAEIK LKSESRVKLF YLDPDAQKLD
FTSAEPEVKP FEEKFGKRIL VKCNDLSFNL QCCVAENEEG PTTNVEPFFV TLSLFDIKYN
RKISADFHVD LNHFSVRQML ATTSPALMNG GRPSSPVLQD ILQEAAMQYP KQGIFSVTCP
HPDIFLVARI EKVLQGSITH GAEPYMKSSD SSKVAQKVLK NAKQACQRLG QYRMPFAWAA
RTLFKDTSGN LDKNARFSAL YRQDSNKLSN DDMLKFLADF RKPEKMAKLP VILGNLDITI
DNVSSDFPNY VNSSYIPMKQ FETCSKTPIT FEVEEFVPCI PKHTQPYTIY NNHLYVYPKY
LKYDSQKSFA KARNIAICIE FKDSDEEDSQ PLKCIYGRPG GPVFTRSAFA AVLHHHQNPE
FYDEIKIELP TQLHGKHHLL FTFFHVSCDS SSKGSTKKKD VVETQVGYSW LPLLKDGRVV
TSEQHVPVSA NLPSGYLGYQ ELGMGRHYGP EIKWVEGSKP LLKVSTHLVS TVYTQDQHLH
NFFQYCQKTE SGAQALGSEL VKYLKSLHAM EGHVMIAFLP TILNQLFRVL TRATQEEVAV
NVTRVIIHVV AQCHEEGLES HLRSYVKYAY KAEPYIASEY KTVHEELTKA MTTILKPSAD
FLTSNKLLKY SWFFFDVLIK SMAQHLIENS KVKLLRNQRF PASYHHAVET VVNMLMPHIT
QKFRDNPEAS KNANHSLAVF IKRCFTFMDR GFVFKQINNY ISCFAPGDPK TLFEYKFEFL
RVVCNHEHYI PLNLPMPFGK GRIQRYQDLQ LDYSLTDEFC RNHFLVGLLL REVGTALQEC
REVRLIAISV LKNLLIKHSF DDRYASRSHQ ARIATLYLPL FGLLIENVQR INVRDVSPFP
VNPGSTVKEE SLLLPAANPL VTPQKPGIAL DNSLHKDLFG AISGIASPYT TSTPNINSVR
NADSRGSLIS TDSGNSLPER NTEKSNSLDK HQQSGTLGNS VVRCDKLDQS EIKSLLMCFL
YILKSMSDDA LFTYWNKAST SELMDFFTIS EVCLHQFQYM GKRYIARNQE GLGPIVHDRK
SQTLPVSRNR TGMMHARLQQ LGSLDNSLTF NHSYGHSDAD VLHQSLLEAN IATEVCLTAL
DTLSLFTLAF KNQLLADHGH NPLMKKVFDV YLCFLQKHQS ETALKNVFTA LRSFIYKFPS
TFYEGRADMC AALCYEILKC CNSKLSSIRT EASQLLYFLM RNNFDYTGKK SFVRTHLQVI
ISVSQLIADV VGIGGTRFQQ SLSIINNCAN SDRLIKHTTF SSDVKDLTKR IRTVLMATAQ
MKEHENDPEM LVDLQYSLAK SYASTPELRK TWLDSMARIH VKNGDLSEAA MCYVHVTALV
AEYLTRKGMF RQGCTAFRVI TPNIDEEASM MEDVGMQDVH FNEDVLMELL EQCADGLWKA
ERYELIADIY KLIIPIYEKR RDFERLAHLY DTLHRAYSKV TEVMHSGRRL LGTYFRVAFF
GQGFFEDEDG KEYIYKEPKL TPLSEISQRL LKLYSDKFGS ENVKMIQDSG KVNPKDLDSK
YAYIQVTHVI PFFDEKELQE RKTEFERSHN IRRFMFEMPF TQTGKRQGGV EEQCKRRTIL
TAIHCFPYVK KRIPVMYQHH TDLNPIEVAI DEMSKKVAEL RQLCSSAEVD MIKLQLKLQG
SVSVQVNAGP LAYARAFLDD TNTKRYPDNK VKLLKEVFRQ FVEACGQALA VNERLIKEDQ
LEYQEEMKAN YREMAKELSE IMHEQICPLE EKTSVLPNSL HIFNAISGTP TSTMVHGMTS
SSSVV
//
