ID A0A3Q7SG15_VULVU Unreviewed; 476 AA.
AC A0A3Q7SG15;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Homeobox protein Meis2 isoform X2 {ECO:0000313|RefSeq:XP_025854216.1};
GN Name=MEIS2 {ECO:0000313|RefSeq:XP_025854216.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025854216.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025854216.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025854216.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025854216.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the TALE/MEIS homeobox family.
CC {ECO:0000256|ARBA:ARBA00009661}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_025854216.1; XM_025998431.1.
DR AlphaFoldDB; A0A3Q7SG15; -.
DR STRING; 9627.ENSVVUP00000036818; -.
DR Ensembl; ENSVVUT00000048375; ENSVVUP00000036818; ENSVVUG00000026356.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0001654; P:eye development; IEA:Ensembl.
DR GO; GO:0045638; P:negative regulation of myeloid cell differentiation; IEA:Ensembl.
DR GO; GO:0110024; P:positive regulation of cardiac muscle myoblast proliferation; IEA:Ensembl.
DR GO; GO:0045931; P:positive regulation of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0008542; P:visual learning; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR032453; PKNOX/Meis_N.
DR PANTHER; PTHR11850:SF47; HOMEOBOX PROTEIN MEIS2; 1.
DR PANTHER; PTHR11850; HOMEOBOX PROTEIN TRANSCRIPTION FACTORS; 1.
DR Pfam; PF05920; Homeobox_KN; 1.
DR Pfam; PF16493; Meis_PKNOX_N; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00108,
KW ECO:0000313|RefSeq:XP_025854216.1};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000286640}.
FT DOMAIN 273..336
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 275..337
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 192..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..257
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 476 AA; 51599 MW; 148484564A743F99 CRC64;
MFLYDELPHY GGMDGVGVPA SMYGDPHAPR PIPPVHHLNH GPPLHATQHY GAHAPHPNVM
PASMGSAVND ALKRDKDAIY GHPLFPLLAL VFEKCELATC TPREPGVAGG DVCSSDSFNE
DIAVFAKQVR AEKPLFSSNP ELDNLMIQAI QVLRFHLLEL EKVHELCDNF CHRYISCLKG
KMPIDLVIDE RDGSSKSDHE ELSGSSTNLA DHNPASWRDH DDATSTHSAG TPGPSSGGHA
SQSGDNSSEQ GDGLDNSVAS PGTGDDDDPD KDKKRQKKRG IFPKVATNIM RAWLFQHLTH
PYPSEEQKKQ LAQDTGLTIL QVNNWFINAR RRIVQPMIDQ SNRAGFLLDP SVSQGAAYSP
EGQPMGSFVL DGQQHMGIRP AGLQSMPGDY VSQGGPMGMS MAQPSYPPPQ LTAHPTQLRH
GPPMHSYLPS HPHHPAMMMH GGPPTHPGMT MSAQSPTVLN SVDPNVGGQV MDIHAQ
//
