ID A0A3Q7SHN2_VULVU Unreviewed; 1440 AA.
AC A0A3Q7SHN2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Rho guanine nucleotide exchange factor 12 isoform X5 {ECO:0000313|RefSeq:XP_025854836.1, ECO:0000313|RefSeq:XP_025854837.1};
GN Name=ARHGEF12 {ECO:0000313|RefSeq:XP_025854836.1,
GN ECO:0000313|RefSeq:XP_025854837.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025854836.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025854836.1, ECO:0000313|RefSeq:XP_025854837.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025854836.1,
RC ECO:0000313|RefSeq:XP_025854837.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025854836.1,
RC ECO:0000313|RefSeq:XP_025854837.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004370}.
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DR RefSeq; XP_025854836.1; XM_025999051.1.
DR RefSeq; XP_025854837.1; XM_025999052.1.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0007266; P:Rho protein signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd13390; PH_LARG; 1.
DR CDD; cd08754; RGS_LARG; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR037801; ARHGEF12_PH.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR037884; LARG_RGS.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR015212; RGS-like_dom.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR PANTHER; PTHR45872:SF3; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12; 1.
DR PANTHER; PTHR45872; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF09128; RGS-like; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640}.
FT DOMAIN 1..33
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 684..874
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 916..1029
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 153..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 471..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 570..612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1035..1054
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1064..1099
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1180..1212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1322..1364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 471..493
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 525..539
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1084..1098
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1183..1203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1440 AA; 161290 MW; 377D37006F589F6E CRC64;
MRAGVQTGDR IIKVNGTLVT HSNHLEVVKL IKSGSYVALT VQGRPPGSPQ IPLADSEVEP
SVIGHMSPIM TSPHSPGASG NMERITSPVL MGEENNVVHN QKVEILRKML QKEQERLQLL
QEDYNRTPAQ RLLKEIQEAK KHIPQLQEQL SKATGSAQDG AVVTSSKPVG EPLTASEVEA
DPGEGIGRLD YCTGDASRPG SDSADSPKSA LKERICLEEN PEKSEVIQDT DTQSLFGSPS
PRIAAHIIGA EDDDFGTEHE QINGQCSCFQ SIELLKSRPA HLAVFLHHVV SQFDPATLLC
YLYSDLYKQT NSKETRRVFL EFHQFFLDRS AHLKVSVPDE ISVDLEKRRP ELIPEDLHRH
YIQTMQERVH PEVQRHLEDF RQKRSMGLTL AESELTKLDA ERDKDRVTLE KERACAEQIV
AKIEEVLMTA QPVEEDKSST MQYVILMYMK HLGVKVKEPR NLEHKRGRIG FLPKIKQSMK
KDREGEEKGK RRGFPSILGP PRRPSRHDNS AIGRAMELQK QRHPKHLSTP SSVSPEPQDP
AKLRQSALAG EGTEVGYLPA NPMSSVAAGA ALSQEGGKEN DTGSKQVGET PASGDCIDNT
PRTPNTVFDF PPPPLDQVQE EEWEVERVTE HGTPKPFRKF DSIAFGESQS EDEQFENDLE
TDPPNWQQLV SREVLLGLKP SEIKRQEVIN ELFYTERAHV RTLKVLDQVF YQRVSREGIL
SPSELRKIFS NLEDILQLHI GLNEQMKAVR KRNETSVIDQ IGEDLLTWFS GPGEDKLKHA
AATFCSNQPF ALEMIKSRQK KDSRFQTFVQ DAESNPLCRR LQLKDIIPTQ MQRLTKYPLL
LDNIAKYTEW PMEREKVKKA ADHCRQILNY VNQAVKEAEN KQRLEDYQRR LDTSNLKLSE
YPNVEELRNL DLTKRKMIHE GPLVWKVNRD KTIDLYTLLL EDILVLLQKQ DDRLVLRCHS
KILASTADSK HTFSPVIKLN TVLVRQVATD NKALFVISMS DNGAQIYELV AQTVSEKTVW
QDLICRMAAS VKEQSAKPIP LPQSPPCEGD NDEEAAPKLK VEHHSISVPG LQSPDRDLGL
ESPLISSKPQ SHSLGTSGKS EVDDLFVAER QFAKEQHTDG TLQEAGGSYQ ITIPDPHLPA
SEERWALDAL RNLGLLKQLL VQQLGLTEKS AQEDWPHFPR YRTASSGVQT DSGTQNSENS
KAYPPGEGQM PFRTGTGDIS TCYSPRTSTE SSAPRDSVVL AFQESQASNI LVMDHMIMTP
EMPPAEPEGS LDESGEHFFD AREAHSDDNP SEGDGAVKKE EDVNLRISGN YLILDGYEAV
QESSTDEEVA SSLPPPPTAG IPAMDCARPQ QHSPQHAHSD GAASPFTPEF LVQQRWGAME
DSCFEIQSPP SCADSQSQIM EYIRKIEADL EHLKKVEESY SILCQRLAGS ALTDKHSDKS
//
