ID   A0A3Q7SIM0_VULVU        Unreviewed;      1502 AA.
AC   A0A3Q7SIM0;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=GATOR complex protein DEPDC5 isoform X6 {ECO:0000313|RefSeq:XP_025841675.1};
GN   Name=DEPDC5 {ECO:0000313|RefSeq:XP_025841675.1};
OS   Vulpes vulpes (Red fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX   NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025841675.1};
RN   [1]
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (JAN-2019) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_025841675.1}
RP   IDENTIFICATION.
RC   STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025841675.1};
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_025841675.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_025841675.1; XM_025985890.1.
DR   Proteomes; UP000286640; Unplaced.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd04449; DEP_DEPDC5-like; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR045838; DEPDC5_CTD.
DR   InterPro; IPR027244; IML1.
DR   InterPro; IPR048255; IML1_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR13179; DEP DOMAIN CONTAINING PROTEIN 5; 1.
DR   PANTHER; PTHR13179:SF8; GATOR COMPLEX PROTEIN DEPDC5; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF19418; DEPDC5_CTD; 1.
DR   Pfam; PF12257; IML1; 1.
DR   SMART; SM00049; DEP; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50186; DEP; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000286640}.
FT   DOMAIN          1087..1162
FT                   /note="DEP"
FT                   /evidence="ECO:0000259|PROSITE:PS50186"
FT   REGION          427..454
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          475..525
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          621..641
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          978..1068
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        427..443
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        480..494
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        495..525
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        624..641
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        984..1068
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1502 AA;  170480 MW;  B10EE3F4E40E4986 CRC64;
     MRTTKVYKLV IHKKGFGGSD DELVMNPKVF PHIKLGDIVE IAHPNDEYSP LLLQVKSLKE
     DLQKETISVD QTVTQVFRLR PYQDVYVNVV DPKDVTLDLV ELTFKDQYIG RGDMWRLKKS
     LVSTCAYITQ KVEFAGIRAQ AGELWVKNEK VMCGYISEDT RVVFRSTSAM VYIFIQMSCE
     MWDFDIYGDL YFEKAVNGFL ADLFTKWKEK NCSHEVTVVL FSRTFYDAKS LDEFPEINRA
     SIRQDHKGRY YEDFYKVVVQ NERREEWTSL LVTIKKLFIQ YPVLVRLEQA EGFPQGDNST
     SAQGNYLEAI NLSFNVFDKH YINRNFDRTG QMSVVITPGV GVFEVDRLLM ILTKQRMIDN
     GIGVDLVCMG EQPLHAVPLF KLHNRSAPRD SRLGDDYNIP HWINHSFYTS KSQLFCNSFT
     PRIKLAGKKP ASEKAKNGRD TSLGTPKESE NALPIQVDYD AYDAQVFRLP GPSRAQRLAT
     CRSVRERDSH NRKSASSCDV SSSPSLPSRA LPTEEVRSQA SDDSSLGRSA NILMIPHPHL
     HQYEVSSSLG YTSTRDVLEN MMEPPQRDSS APGRFHVGSA ESMLHVRPGG YTPQRALINP
     FAPSRMPMKL TSNRRRWMHT FPVGMNPRTQ NKDSLEDSVS TSPDPILTLS APPVVPGFCC
     TVGVDWKSLT TPACLPLTTD YFPDRQGLQN DYTEGCYDLL PEADIDRRDE EGVQMTAQQV
     FEEFICQRLM QGYQIIVQPK AQKSNPIVPP PLSSSPLYSR GLVSRNRPEE EDQYWLSMGR
     TFHKVTLKDK MITVTRYLPK YPYESAQIHY TYSLCPSHSD SEFVSCWVEF SHERLEEYKW
     NYLDQYICSA GSEDFSLIES LKFWRTRFLL LPACVTATKR ITEGEAHCDI YGDRPRADEE
     EWQLLDGFIR FVEGLNRIRR RHRSDRMMRK GTAMKGLQMT GPIATHSLES TGPPVGKKGT
     SALSALLEME ASQKCLGEQQ AAVHGGKSAS QPAESSSVAM TPTYVDSPRK VSVDQTATPV
     LDSTSLGVST GQSVDRGNSQ AFGNNQNSGE QSFPSANSSD SSSQQLAASS LTSSSTLTEI
     LEAMKHPSTG VQLLSEQKGL SPCCFISAEV VHWLVNNVEG VQTQAMAIDI MQKMLEEQLI
     THASGEVWRT FIYGFYFYKI VMDKEPDRVA MQQPTTWHTT AGEDFASFQR KWFEVAFVAE
     ELLHSEIPAF LLPWLPSRPA SYASRHSSFS RSFGGRSQAA ALLAATVPEQ RTVTLDVDVN
     NRTDRLEWCS CYYHGNFSLN AAFEIKLHWM AVTAAVLFEM VQGWHRKATS CGFLLVPVLE
     GPFALPSYLY GDPLRAQLFI PLNTSCLLKE GSEHLFDSFE PETYWDRMHL FQEAIAHRFG
     FVQDKYSASA FNFPAENKPQ YIHVTGTVFL QLPYSRRKFS GQQRRRRNST SSTNQNLFCE
     ERVGYNWAYN TMLTKTWRSS ATGDEKFADR LLRDFTDFCI NRDNRLVTFW MSCLEKMHAS
     AP
//