ID A0A3Q7SJW1_VULVU Unreviewed; 5212 AA.
AC A0A3Q7SJW1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=E3 ubiquitin-protein ligase RNF213 isoform X5 {ECO:0000313|RefSeq:XP_025855696.1};
GN Name=RNF213 {ECO:0000313|RefSeq:XP_025855696.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025855696.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025855696.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025855696.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025855696.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_025855696.1; XM_025999911.1.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR031248; RNF213.
DR InterPro; IPR046439; ZF_RZ_dom.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR22605:SF16; E3 UBIQUITIN-PROTEIN LIGASE RNF213; 1.
DR PANTHER; PTHR22605; UNCHARACTERIZED; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR Pfam; PF20173; ZnF_RZ-type; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
DR PROSITE; PS51981; ZF_RZ; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 4007..4045
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 4489..4561
FT /note="RZ-type"
FT /evidence="ECO:0000259|PROSITE:PS51981"
FT REGION 20..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..67
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..114
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..254
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..321
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5212 AA; 591395 MW; 8C09DC0044FE9C4A CRC64;
MECVSCGYVS KDKAPKFCSQ CGQRLRQAAE PDSENNRGGE AAAAPDGEVE PGQELREDGE
VEPGQELRED GGPFLSSGSR GPLPPRGLDE PPSSASLSLS SRRRRRRGGR KRKKQNAFTS
AEPGSLSEAP SVPCSVSLLA DPGARDTAPP QGQAPQGAPS SQPSQPLGTV PSPLEGAGPP
GPPGHAEVGG SPLPDQTAGS APQNGKGRDT PSPSKGVGAT ASASKDCPGK EDASRELLLP
ESKRVPEPRK EPQTPRQEAG ACASGEIAAA AQPAQPVGGA GEKDKAKAKT QKLNQPPAGT
PAPPEHHQTA EPKKKMASPA DKAGGSEKAK PGGPKKPEGN NKSCVATTKN EKEQRDLKAR
GSEVMGSSPL SVQEGVTVYF HAIIPKDCIV NRSSHQVFVR GGEEFGKLRW QRNVCEMDYT
KDLHEHGYLA EGCTVLSRQH VDKPIPYKYV IVDSNGCCEY EFIYKQKQKH GDHVNRCLLV
RSQLLALGDW HQYDDMVRME SPGKLQKLMS SVTDGIRKDL VRGKQVAATF MLDNIFSLLK
AWGTINLRSF FMQFQQFFSV VRVPMIYEGQ AQPWLSLKYE EKEVKKHLWE YLKKQAAPLL
ESSVDPLPED HPVKSPLRMG LIVLFAVEKF NIPLSDSDLS MLCTLLCSNI RSPGDLHSDL
SDIFETYQSW REALVNLCQK CMEQTVDHWV LTLPLLHYCM ELFLQGKDCR MQPEDTWAAL
EGISFSEFRE KRPDQTHLVK LMSKYNRLLN VDVYLFRSWF SLVPLSNLLD YMENFVEYQS
DVPACILDCL QGTWYRLQHY TQLFKRHQEN IGKILTKLLG LLNICQDKIL EEPLIRSYLT
VGQKLHETIC SITKHEALYE LLALSAEIVC RIITLQPLVQ DSAEGLGKEA RRNSVHAVFQ
GTITSTRAWL QSVFRERIFY IISAETVLTF RYRDEIQVWR QLMKINFPVE YGWKESLLED
LEGRIKQEKP FDQICIFCGP QWDARGQEDS VSKCFEKCVV EAVSAAIQNQ TSILERISYH
NLQNFGTLVS AVITKSWPRN EDAPHYLDEV LEHLLTCPDI KHLFKLCRTN QKILANITED
SKELWATGNS VFREVGEDLV HGTILVRHLE LIEKHTDQFL GIWESKRKSL SSLENEHNVE
EVLVWRMDEL SSLKREKKCV SSLLSMCEKV KQLVQVDLEK MVEKNLEDLG SKRLCDIVTV
RLSSSFLDMK RTVHYNLSPH IQEMAEKVDQ LKDSHIFQVF WENTAEGLRK PEEELERQIL
QLEEVYTYLY VPCFEKFMKL YEDLRSGKIT FQEVNTVFKD FVNKYSNLTS DLRTMCALDP
SDQQDWIEDR VAQIQEYHHL DQAVSSAKVI LEVKENLGLI GNFNVLHTLL HFTDNFDKYR
HEKLEQISKE LIRAKKLLDD ISETRSQCLK ELALRKEFIS WVREALGGIN ELKVFVDLAS
ISAGENDIDV DRVACFHDAV QGSASLLYKL DTSAGFNEFM MHLKEVWKAL EKDPHLPHKL
RDSARNLEWL KTVRESHGSV ELSSLSLATA INTKGIYMIG APTDGQKISP DTVLQLLLPE
SHGDHEEVRV YSLEQLKELL NKLMLMSGKK DHGNVQVEVF SKVFSNVQRL VQSFINLYCA
GNMLFRAWKA EVFCSPRHGV SLRMDFCLTL INQLKGTGPV VELLEAVSRQ MEDFLDHWIS
FVAEKRAKHF YLNYYTAEQL VYLSTQLKEP KPSTAALTML SFIKGNCTLR DVKEALRESS
GKAARHHERT AAEGLRQALP HEFSLVDKLR AILEQSMACM SAFLPHCLDL EALGLYLASL
ARMNRHPVER DLPKGLHVGQ PNLIVCGHSE VLPAALAIYR HMENEPLPTF DEMLLCTPGT
TFEEVALLLR RCLTPGSRGR GIYSLLYADL LSYEVACQAE TLFLHLCLQA HQGDFQLVMI
CDSEREHCHL PSAFSQHKVL ITPQASLQDI QAYLAKHFQV PENIPSAADV FRDRMCVGVV
TSKRAGVGKS LYVERLHSKL ERKLRDKEVP LKVIRLIDPQ VDEKKVLSSL LPFLKSCYQT
MPVIFHFDVT SSVQTGLWVF IFKLLILRYL MDINGKIWLR NPCHLYIIEI LETTPALPKA
PSRQSTHTPQ FNFLDVFPKV TCRPPKEVIN MELNPEENYN DPGMDLTVFR SETFQRPYQY
LKRFHEKRNL DNFQYQEGSV EGTPEECLQY FLIYCGVIDP SWSELQNFAG FLNYQLRDCE
ASVFCNPHVV GDTLQGFKNF VVTFMIFMAR DFATPTLHTN DQSPGRHAVI MDGVREEDLA
PFSLRKRWES EPHPYVFFNG DHTSMTFIGF HIQSNRNASL DAIHPSSGRV IKKDVMGQKL
YQGLLLQRVP FNVDFDQLPR QEKLAKLCLA LGIKCPIDPD DTYEITTDNM LKILAIEMRF
RCGIPVIIMG ETGCGKTRLV KFLSDLRCGR TKAKTMKLVK VHGGTTAEMI YAKVREAEKL
ALLNKEQYRL DTILFFDEAN TTEAISCIKE VLCDRTVDGQ PLVKDSGLQI IAACNPYRKH
SQEMICRLES AGLGYRVRAE DTAERLGSIP LRQLVYRVHA LPPSLIPLVW DFGQLNNDAE
KLYIQQIMQR LVGSIRIDKD KTHVITEVLS TSQGFMRTRV NECSFVSLRD VERCVRVFRW
FYNRSEMLLA KLDSFLQQSH VSKNNFKRDP VLWSLVLALG VCYHASLEQK EPYWKDICMF
FPEPYNDSKV ILEEITQTQD LFLDGVSLRK TIARNAALKE NVFMMVICIE LKIPLFLVGK
PGSSKSLAKT VVADAMQGPA AHSDLFRSLK QVHLVSFQCS PHSTPQGIIS TFKQCARFQQ
EKDLHQYVSV VVLDEVGLAE DSPKMPLKAL HPLLEYGCVE DNPAPHKKVG FIGISNWALD
PAKMNRGIFV SRGSPNKKEL IESAKGICSS EPLVQKRVQG FFAPFAKAYE TVCEKQDKEF
FGLRDYYSLI KMVFAKAKAS NKEPSPQDIA QAILRNFSGK DDIHALDIFT ANLPEAKCSE
EVSTMQLIQQ NMYGDLQTVP GRELDDSESR YLLVLTRNYA ALQVLQQQMF FSENQQPEII
FGSSFPRDQE YTQVCRNINR VKICMETGKM VVLLNLQSLY ESLYDALNQY YVYLGGQKYV
DLGLGTHRVK CRVHPDFRLI VIEEKDVVYK HFPIPLINRL EKHYLDINTV LEKWQKSIVE
ELKTWVENFV EVKTEHFIAI HKYSPSEVFI GYHPDACASV VLQVTQRLGP NFPTDELYQK
VSQEAKLVLL GCATPDAVVR LGTSSLGLFT AQFLSREYYH KQQHNSFADF LQAQLHAVDL
ERRVIFTEIT TFSRLLTSHD CKILESEVMD GDVRPTILSL QQFDTESSFL RRVQNCLTKV
AKCKILIIQT DFEDGVRSAQ LIASAKYSAI NEINKIQGNE DRILVYFITK LSRMESGAAY
VGFHGGLWQS VHIDDLQKST VMIADVTKLQ DVAISQLFEP EEKAELETGQ EAGDGLGEAM
EIGLGEVMEI EASASGEVAE GSSAPEGSWH AERGRSDVLD TSSLLRSCVQ GAVGMLRDRE
DTRPRGMQRV EILLGLLSED HADRGAGARA VPSARPLGSP AAAFLRVCKA RLHGLLKQQE
ESSAFSRKDW VSREASNQDA LQEAGTFRQT LWKRVQGMVT PLLASMVSVL DRDSNLELLI
RQDAPSWTRD LWMFIFQDTK LLNIPLVTYD MRSKSEMPYI MVHNDMSPPE GVSGDVPFSW
RIKDYLEELW VQAQYITGAE AGLSKMLVEI FQQTPLGRFL AQLSVKQQQE LFVSYMKDFL
LLTMRPSTWD QLKVLQMALS SCISQLHTQR PDEQLSLAWV HLAYQHFRSR LQNLSRILTI
YPQILQVLLC NMTESTRSDR LDRNELTLDA LAAVACTEVL TRDILKPSPQ VWLQMVKNLS
MPLELLGSKG YLQSCGKMAR DAIREVRIHW NRIFPVALFV EHVVLGVRSK IPELQALVTD
HVFLLNKYLQ DDSDIKTYRP FVTVMHTLCK CKEQASKTLS RFEIQPCPVC LGDAQEPVSL
PCSHVFCLRC INTCVTLGQM ACPYCLTDLP KDFSLTVNQE HRDAIRKHAS LRQMCNSFFL
DLVSTVCFKD NTPPEKDVID VLLSLLFVQK EFLRDAPQRH CEHTKSLSPF DDIVDKTPVI
RSVVLKLLLK YSFQEVKDYI RAYLSLLQQK ALVTEDKTEL YILFSNCLED SLYEKTRVLS
TSEELRYLRE EGAFLKTYSM SRSPEPASEA SVEHLQEMAR IRLCLDKASH FLSELQDGSE
TAREKQCYLQ QVERFCRQAK NDWYRVYLVR KLSSQRGIEY VQQFCAQGHP ARWIFPEGAL
LREENMLSQM DRYLVHGDKY KALRDTVGKA ILQNEPLTTV AVLKGGRNHD PKLAAHFLLA
LFREVAVLYQ SCNTSLHPKP EQCEALNAFI EEGKILSSPH MRHFAASLVN NTLPLLRTGP
GDSSLQGTVA ELAVHTAAVL LCGQGDILEP LKSLAFSPAH MVNSYLPTMP EDLLVQARNW
KGLETLSWYM CPNGHPCSVG ECGKPMEKSY CVDCGVQVGG VNHSPEAGFQ AITDKTDRTQ
KGHVLGAPPS RDEVLVSDRE LAPAVFLLIR LLTHLALLLG ATQRPEAVMR IIKPPVQDPS
GFLQRHIHRD LEQLAKTLGR SADEATTTVH LMLCSLLRGQ GRLSSWRPPC FKANLETREQ
RNSWEKAMQT LLLPELEHLE KALLTVTASI SQDERISSNP VARIVYKDPT VFLPHLPQKS
VFHCSKMWTC RRKVTVEYLQ HIVEQKNGKE SVPILWKFLQ KEAELRLVRF LPEILALQRD
LVRRFQNASD ADYQSIRSFI SSHQGDGLKQ LFHRRIQIFL STWNKLRRSL QTNGEIKLPD
SYCSADLDMD TNFEVILPRR RGLGLCSTAL VSYLISLHND MVYAVGKFSD ENNSYSVDAS
EVTDLHIISY EVEQDLMPLI LSNCQYQVEQ GKETLQEFDL EKIQRQVTGR FLQGKPRITL
MGIPTLVYRR DWNYEQLFMD IKNKMLQKPL PNATISSIRG QLPSYSDGCK ALSVIEVTLG
FLSTAGGDPN MSLNEYVQDM LRMGDQAELV LKAFNRCQLK HAIALWQILS AHRSEQLLRL
QKEPFRDISS RYKVHLSPEN AKCLSTFLNQ TDLDAFLLEL HEMMILKLKS PQAEDNFRPE
WSLRDTLVSY METKDGEIPP ELEYQFPEEI LLSNCVPAWS LAVGLKRARH AK
//
