ID A0A3Q7SJX9_VULVU Unreviewed; 517 AA.
AC A0A3Q7SJX9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Fascin-2 isoform X1 {ECO:0000313|RefSeq:XP_025855716.1};
GN Name=FSCN2 {ECO:0000313|RefSeq:XP_025855716.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025855716.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025855716.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025855716.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025855716.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the fascin family.
CC {ECO:0000256|ARBA:ARBA00007415}.
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DR RefSeq; XP_025855716.1; XM_025999931.1.
DR AlphaFoldDB; A0A3Q7SJX9; -.
DR KEGG; vvp:112920889; -.
DR OrthoDB; 5484756at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:InterPro.
DR GO; GO:0007015; P:actin filament organization; IEA:InterPro.
DR CDD; cd00257; Fascin; 4.
DR Gene3D; 2.80.10.50; -; 4.
DR InterPro; IPR008999; Actin-crosslinking.
DR InterPro; IPR010431; Fascin.
DR InterPro; IPR022768; Fascin-domain.
DR InterPro; IPR024703; Fascin_metazoans.
DR PANTHER; PTHR10551; FASCIN; 1.
DR PANTHER; PTHR10551:SF24; FASCIN-2; 1.
DR Pfam; PF06268; Fascin; 4.
DR PIRSF; PIRSF005682; Fascin; 2.
DR SUPFAM; SSF50405; Actin-crosslinking proteins; 5.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640}.
FT DOMAIN 21..133
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
FT DOMAIN 142..254
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
FT DOMAIN 266..376
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
FT DOMAIN 453..517
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
FT REGION 427..468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 517 AA; 56865 MW; 1034133D410C1D11 CRC64;
MPTNGLHQVL KIQFGLVNDA DRYLTAESFG FKVNASAPSL KRKQMWVLEP DPGHGSAVLL
RSSHLGRYLS AEEDGRVACE AERPGRDCRF LVLPQPDGRW VLRSEPHGRF FGGTEDRLSC
FATAISAAEL WTVHLAIHPQ AHLLSVSRRR YVHLCPREDE MAADSNTPWG VDALITLIFQ
NRQYCLKSCD SRYLRSDGRL VWEPEASARY TLEFKAGKLA FKDCDGRYLA PAGPAGSLRA
GRNTRPGKDE LFDLEESHPQ VVLLAANRRY VSVRQGVNVS ANQDEELHHE TFLMQIDGDT
GKCTFYSSTG GYWTLVAHGG IQATATQVSA NTMFEVEWRG RRVALKASNG RYVCMKKNGQ
LAAVSDFVGE DEEFILKLIN RPILVLRGLD GFVCHRRGSN QLDTNRSVYD VFHLSFSDGA
YQIRGGPWGG GGARGGGPPG APADPPSPPG RGGGFWNTGS HGSVRSDGER PEDFLFEFRG
RGRLAIRARG GKYLRGGASG LLRADADAPA GLALWEY
//
