ID   A0A3Q7SK57_VULVU        Unreviewed;       507 AA.
AC   A0A3Q7SK57;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Keratin, type II cuticular Hb5 isoform X1 {ECO:0000313|RefSeq:XP_025855816.1};
GN   Name=LOC112920995 {ECO:0000313|RefSeq:XP_025855816.1};
OS   Vulpes vulpes (Red fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX   NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025855816.1};
RN   [1]
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (JAN-2019) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_025855816.1}
RP   IDENTIFICATION.
RC   STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025855816.1};
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_025855816.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000256|RuleBase:RU000685}.
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DR   RefSeq; XP_025855816.1; XM_026000031.1.
DR   AlphaFoldDB; A0A3Q7SK57; -.
DR   STRING; 9627.ENSVVUP00000039108; -.
DR   KEGG; vvp:112920995; -.
DR   OrthoDB; 4640531at2759; -.
DR   Proteomes; UP000286640; Unplaced.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.20.5.500; Single helix bin; 1.
DR   Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR032444; Keratin_2_head.
DR   InterPro; IPR003054; Keratin_II.
DR   PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR45616:SF43; KERATIN, TYPE II CUTICULAR HB5; 1.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF16208; Keratin_2_head; 1.
DR   PRINTS; PR01276; TYPE2KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW   ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW   Reference proteome {ECO:0000313|Proteomes:UP000286640}.
FT   DOMAIN          123..434
FT                   /note="IF rod"
FT                   /evidence="ECO:0000259|PROSITE:PS51842"
FT   COILED          127..161
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          204..259
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          332..412
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   507 AA;  55880 MW;  8C28FB56CF5B146C CRC64;
     MSCRSYRISS GCGVTRTFSS CSAVAPKTGN RCCISAAPYR GVSCYRGLTG FGSRSLSNLG
     SCGPRMAVGG FRAGSCGRSF GYRSGGVCGP SPPCITSVSV NESLLTPLNL EIDPNAQCVK
     HEEKEQIKCL NNRFAAFIDK VRFLEQQNKL LETKWQFYQN QRCCESNLEP LFNGYIETLR
     REAECVEADG GRLASELNHV QEVLEGYKKK YEEEVALRAT AENEFVVLKK DVDCAYLRKS
     DLEANVEALV EESNFLKRLY DEEIRVLHAH ISDTSVIVKM DNSRDLNMDC IVAEIKAQYD
     DIVSRSRAEA ESWYRSKCEE MKATVIRHGE TLRRTKEEIN ELNRMIQRLT AEIENAKCQR
     AKLEAAVAEA EQQGEAALTD ARCKLAELEA ALQKAKQDMA CLVKEYQEVM NSKLGLDIEI
     ATYRRLLEGE EQRLCEGVGS VNVCVSSSRG GVACGGLTYS STPGRQIASG PAATGGSITV
     MAPDSCAPCQ PRQASFTCSS SRSVRFA
//