ID A0A3Q7SKC8_VULVU Unreviewed; 443 AA.
AC A0A3Q7SKC8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Potassium channel subfamily K member 2 isoform X1 {ECO:0000313|RefSeq:XP_025856901.1, ECO:0000313|RefSeq:XP_025856903.1};
GN Name=KCNK2 {ECO:0000313|RefSeq:XP_025856901.1,
GN ECO:0000313|RefSeq:XP_025856903.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025856903.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025856901.1, ECO:0000313|RefSeq:XP_025856903.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025856901.1,
RC ECO:0000313|RefSeq:XP_025856903.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025856901.1,
RC ECO:0000313|RefSeq:XP_025856903.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000256|ARBA:ARBA00006666,
CC ECO:0000256|RuleBase:RU003857}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_025856901.1; XM_026001116.1.
DR RefSeq; XP_025856903.1; XM_026001118.1.
DR KEGG; vvp:112921786; -.
DR OrthoDB; 600333at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005267; F:potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR003976; 2pore_dom_K_chnl_TREK.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR11003:SF21; POTASSIUM CHANNEL SUBFAMILY K MEMBER 2; 1.
DR PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PRINTS; PR01333; 2POREKCHANEL.
DR PRINTS; PR01499; TREKCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU003857,
KW ECO:0000313|RefSeq:XP_025856901.1};
KW Ion transport {ECO:0000256|RuleBase:RU003857};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003857};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857}.
FT TRANSMEM 81..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 189..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 240..261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 306..328
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 154..212
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 255..329
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
SQ SEQUENCE 443 AA; 49080 MW; 1AF73C1E5741B4DE CRC64;
MTVCARDDSL IPCSKEHLSP IIHQTTWSWK HTVAAPDLLD PKSAAQNSKP RLSFSTKPTV
LASRVESDTA INVMKWKTVS TIFLVVVLYL IIGATVFKAL EQPHEISQRT TIVIQKQTFI
SQHSCVNSTE LDELIQQIVA AINAGIIPLG NTSNQISHWD LGSSFFFAGT VITTIGFGNI
SPRTEGGKIF CIIYALLGIP LFGFLLAGVG DQLGTIFGKG IAKVEDTFIK WNVSQTKIRI
ISTIIFILFG CVLFVALPAI IFKHIEGWSA LDAIYFVVIT LTTIGFGDYV AGGSDIEYLD
FYKPVVWFWI LVGLAYFAAV LSMIGDWLRV ISKKTKEEVG EFRAHAAEWT ANVTAEFKET
RRRLSVEIYD KFQRATSIKR KLSAELAGSH NQELTPCRRT LSVNHLATER DVLPPLLKTD
SIYLNGLTPH CAGEEIAVIE NIK
//