ID A0A3Q7SLE6_VULVU Unreviewed; 1885 AA.
AC A0A3Q7SLE6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Proprotein convertase subtilisin/kexin type 5 isoform X1 {ECO:0000313|RefSeq:XP_025857318.1};
GN Name=PCSK5 {ECO:0000313|RefSeq:XP_025857318.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025857318.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025857318.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025857318.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025857318.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC ECO:0000256|RuleBase:RU003355}.
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DR RefSeq; XP_025857318.1; XM_026001533.1.
DR KEGG; vvp:112922097; -.
DR OrthoDB; 5474719at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00064; FU; 17.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.30.70.850; Peptidase S8, pro-domain; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR032778; GF_recep_IV.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR032815; S8_pro-domain.
DR InterPro; IPR038466; S8_pro-domain_sf.
DR PANTHER; PTHR42884:SF13; NEUROENDOCRINE CONVERTASE 2; 1.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR Pfam; PF14843; GF_recep_IV; 2.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR Pfam; PF16470; S8_pro-domain; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SMART; SM00181; EGF; 14.
DR SMART; SM01411; Ephrin_rec_like; 4.
DR SMART; SM00261; FU; 22.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 6.
DR SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..1885
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018790532"
FT TRANSMEM 1770..1790
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 461..601
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT ACT_SITE 171
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 212
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 386
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 1885 AA; 209382 MW; B0634F1E1635C37E CRC64;
MGWGSRGCGP GRLDLLCVLA LLGGCLLPVC RTRVYTNHWA VKIAGGFPEA DRIASKYGFI
NIGQIGALKD YYHFYHSRTI KRSVLSSRGT HSFISMEPKV EWIQQQVVKK RTKRDYDFSR
AQPTYFNDPK WPSMWYMHCS DNTHPCQSDM NIEGAWKRGY TGKNIVVTIL DDGIERTHPD
LMQNYDALAS CDVNGNDLDP MPRYDASNEN KHGTRCAGEV AAAANNSHCT VGIAFNAKIG
GVRMLDGDVT DMVEAKSVSF NPQHVHIYSA SWGPDDDGKT VDGPAPLTRQ AFENGVRMGR
RGLGSVFVWA SGNGGRSKDH CSCDGYTNSI YTISISSTAE SGKKPWYLEE CSSTLATTYS
SGESYDKKII TTDLRQRCTD NHTGTSASAP MAAGIIALAL EANPFLTWRD VQHVIVRTSR
AGHLNANDWK TNAAGFKVSH LYGFGLMDAE AMVMEAEKWT TVPQQRVCVE STDRQIKTIR
PNSAVRSIYK ASGCSDNPNH HVNYLEHVVV RITITHPRRG DLAIYLTSPS GTRSQLLANR
LFDHSMEGFK NWEFMTIHCW GERATGDWIL EVYDTPSQLR NFKTPGKLKE WSLVLYGTSV
QPYSPTNEFP KVERVRYSRV EDPTDDYGTE DYAGPCDPEC SEVGCDGPGP DHCNDCLNYY
YKLKNNTRIC VSSCPSGHYH ADKKRCRKCA LNCESCFGSH ADQCLSCKYG YFLNEEINSC
VIHCPDGSYP DTKKNLCRKC SENCKTCTEF QNCTECRDGL SLQGSRCSIT CEDGQYFNGQ
DCQPCHRFCA TCAGPGADGC INCTEGYFME DGRCVQSCSL SYYFDHSSEN GYKSCKKCDA
SCLTCNGPGF KNCTSCLSGY LLDLGTCQMG AICKDGEYID EHGHCQICEA SCATCWGPTQ
EDCTSCPITR ILDKGRCVFK CPSGKFEFQN QCHLCHYTCQ ECQGNEPSNC TSCGVDNQGQ
ERFLYQGECW ESCPAGHYPA EGHTCLPCSD NCELCHSAPI CVRCMSGYFV VPTNHTCQKL
QCGQGQIQDP DYEECVPCEE GCLGCSLDDP GTCTSCTMGY YMFDHHCYKT CPEKTYSEEF
ECKACDTNCS NCDQHECYWC EEGFFLLGGT CVRRCGPGFY GNPEVGECEP CHPACKSCVG
LGPHQCSSCQ EGLQLQHGTC VGPAQPHVEG KFWNEPVPTA SPSLVKSLPQ KPRRKFQIKR
DILRGHQPCH PSCKTCGESA TQCTSCPKGT YLLAQACVSS CPEGTWPSAR NGSCENCTED
CASCSGANLC TKCQTWPDFP VFLHKGRCYT TCPEGFYAED SMCTPCSSPC RTCEGNATNC
HSCQGSLILH QGACWEACPE RHVAMEGVCK HCPEMCQDCI HEKTCKECMP QSFLYKDMCH
QSCPQSFYAD LGQCIPCHED CLECSGPSAD DCDLCAEPSL VFYDGQCLDE CPAGTYYEKE
TKDCRDCHKS CQTCLSPGTC TTCQEGLQIN SHGTCMPHKE CTHSEYWDVQ ALKCKPCHAK
CFRCTGPTEE QCHSCPRDSL LLNTICVPDC PEGYYTDEDS HQCVPCHNSC RTCEGRRSTQ
CLSCQPGLFQ LEKECLLYCR EGYYAEISTG RCERCSKSCK TCRGPGPTDC LSCDTFFFLL
RSKGECHPTC PEHYYAEQKN KTCERCHPTC DKCEGKGAWN CLSCVWSYHL MGGICASDCL
VGEYRVGKGD NFTCEKCHES CVECKGPGTK NCTVCPASLL LLMDDGRCLH CCNVSDPSHT
QECCDCRDTT EECILQSSEI GPAGEHTKTA LLITSSVMLV LLLGAAVIVW KKSRGRGEPV
AKPGYEKLAD PNKSYVSYKS SHHQSTSFEE DQVIEYRDRD YDEDDDDDIV YMGQDGTVYR
KFKYGLLDDD EEDELEYDDE SYSYQ
//