ID   A0A3Q7SMN4_VULVU        Unreviewed;      1074 AA.
AC   A0A3Q7SMN4;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Importin-4 {ECO:0000313|RefSeq:XP_025863389.1};
GN   Name=IPO4 {ECO:0000313|RefSeq:XP_025863389.1};
OS   Vulpes vulpes (Red fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX   NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025863389.1};
RN   [1]
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (JAN-2019) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_025863389.1}
RP   IDENTIFICATION.
RC   STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025863389.1};
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_025863389.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   RefSeq; XP_025863389.1; XM_026007604.1.
DR   STRING; 9627.ENSVVUP00000040960; -.
DR   KEGG; vvp:112926543; -.
DR   OrthoDB; 22606at2759; -.
DR   Proteomes; UP000286640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR040122; Importin_beta.
DR   InterPro; IPR034085; TOG.
DR   PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR   PANTHER; PTHR10527:SF6; IMPORTIN-4; 1.
DR   Pfam; PF13513; HEAT_EZ; 2.
DR   SMART; SM01349; TOG; 1.
DR   SUPFAM; SSF48371; ARM repeat; 2.
DR   PROSITE; PS50077; HEAT_REPEAT; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          334..578
FT                   /note="TOG"
FT                   /evidence="ECO:0000259|SMART:SM01349"
FT   REPEAT          386..426
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   REPEAT          893..929
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
SQ   SEQUENCE   1074 AA;  117330 MW;  F2791323097F9BC2 CRC64;
     MEPAGLERLL RELLLPDTER IRRATEQLQT ALRDPAALPA LCDLLASAAD PQIRQFAAVL
     TRXRGTHTCH LCSSLKSLVL TALQRETEHS VSLSLAQLSA TIFRKEGLEA WPQLMQLLQH
     STHSTHIPER EMGLLLLSVV VSSRPEAFQP HHRELLRLLN ETLGEVGSPG LLFYSLRTLT
     TMAPYLGTDD VSLARMLVPK LIVAMQTLIP LDEAKACEAV EALDELLESE VPIITSHLSE
     VLTFCLEVAR NVALGDAIRV RILCCLTFLV KVKSKALLKN RLLPPLLHTL FPIMAAEPAL
     GQLDPEDQDS EEEELEIGLV GETPKHFAVQ VVDMLALHLP PEKLCPLLMP MLEEALRSER
     PYQRKAGLLV LAVLSDGAGD HIRQRLLPPL LQIVCKGLED PSQVVRNAAL FALGQFSENL
     QPHISSYSGD VMPLLLAYLK SVPPGHTNHL AKACYALENF VENLGPKVQP YLPELMECML
     QPLRNPSSPR AKELAVSALG AIATAAQASL LPYFPTIMEH LREFLLAGHG DLQPVQIQSL
     ETLGVLARAV GEPMRPLAEE CCQLGLGLCD QVDDPDLRRC TYSLFAALSG LMGEGLAPHL
     PQITTLMLLS LRSTEGIVPQ YDGSRSFLLF DDESDGEEEE ELMDKDEEEE EDSEISGYSV
     ENAFFDEKED ACAALGEISV NTSVAFLPYV ESVFEEVFKL LECPHLNVRK AAYEALGQFC
     CALHKACQSC PSEPNAAALQ AALARVLPSY IQAVSEERER QVVMAVLEAL TSVLRGCGHL
     ALQPPGRLAE LCGMLRAVLQ RKTACQDTDE EEEEEDQAEY DAMLLEHAGE AIPALAAAVG
     GDTFAPFFAS FLPLLLCKMK QGCTVAEKSF AVGTLAESIQ GLGGASAQFV SRLLPVLLST
     AREADPEVRS NAIFGLGVLA EHGGRPAQEY FPKLLGLLLP LLARERHDRV RDNICGALAR
     LLMAGPTRKP EPQVLAALLH ALPLKEDLEE WVTIGHLFSF LYQSSPDQVV DVAPELLRIC
     SLILADNKIP ADTKAALLLL LTFLARQHTD SFHLALGSLP GDKAQELQAV LGLT
//