ID A0A3Q7SMN5_VULVU Unreviewed; 3710 AA.
AC A0A3Q7SMN5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Vacuolar protein sorting-associated protein 13C isoform X2 {ECO:0000313|RefSeq:XP_025857823.1};
GN Name=VPS13C {ECO:0000313|RefSeq:XP_025857823.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025857823.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025857823.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025857823.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025857823.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lipid droplet {ECO:0000256|ARBA:ARBA00004502}.
CC -!- SIMILARITY: Belongs to the VPS13 family.
CC {ECO:0000256|ARBA:ARBA00006545}.
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DR RefSeq; XP_025857823.1; XM_026002038.1.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005811; C:lipid droplet; IEA:UniProtKB-SubCell.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR InterPro; IPR015412; Atg2/VPS13_C.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR049424; VPS13_C.
DR InterPro; IPR031645; VPS13_DH-like.
DR InterPro; IPR031646; VPS13_extend_chorein.
DR InterPro; IPR031642; VPS13_mid_RBG.
DR InterPro; IPR009543; VPS13_VAB.
DR PANTHER; PTHR16166:SF125; INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13C; 1.
DR PANTHER; PTHR16166; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13; 1.
DR Pfam; PF09333; ATG2-VPS13_C; 1.
DR Pfam; PF12624; Chorein_N; 1.
DR Pfam; PF21679; VPS13_C; 1.
DR Pfam; PF16909; VPS13_DH-like; 1.
DR Pfam; PF16908; VPS13_ext_chorein; 1.
DR Pfam; PF16910; VPS13_mid_rpt; 3.
DR Pfam; PF06650; VPS13_VAB; 1.
PE 3: Inferred from homology;
KW Lipid droplet {ECO:0000256|ARBA:ARBA00022677};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 3..116
FT /note="Chorein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12624"
FT DOMAIN 139..370
FT /note="Vacuolar protein sorting-associated protein 13
FT extended chorein"
FT /evidence="ECO:0000259|Pfam:PF16908"
FT DOMAIN 569..790
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 1132..1230
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 1649..1746
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 2440..2974
FT /note="Vacuolar protein sorting-associated protein 13 VPS13
FT adaptor binding"
FT /evidence="ECO:0000259|Pfam:PF06650"
FT DOMAIN 3281..3458
FT /note="Vacuolar protein sorting-associated protein 13 DH-
FT like"
FT /evidence="ECO:0000259|Pfam:PF16909"
FT DOMAIN 3464..3546
FT /note="Atg2/VPS13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF09333"
FT DOMAIN 3552..3657
FT /note="Intermembrane lipid transfer protein VPS13 C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF21679"
FT REGION 830..852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3710 AA; 417229 MW; F0A68922D0662347 CRC64;
MVLESVVADL LNRFLGDYVE NLNKSQLKLG IWGGNVALDN LQIKENALSE LDVPFKVKAG
QIDKLTLKIP WKNLYGEAVI ATLEGLYLLV VPGASIKYDA EKEEKSLQDI KQKELSRIEE
ALQKAAEKDK PKEAKKDTFF EKLATQVIKN VQVKITDIHI KYEDDVTDPQ QPLSFGVTLG
ELSLLTANEH WTPCILNEAE KIIYKLIRLD SLSAYWNVNC NMSYQESKEQ ILDQLKSGIL
TSSNIPVNHQ YIFQPISASA KLYMNPYAET ELKTPKLDWN IEVQNIAIEM TKPQYLSMID
FLESVDYMVR NAPYRKYKPY LPLHTNGRQW WKYAIDSVLE VHIRRYTQMW SWNNIKKHRQ
LLKSYKSAYK SKLTQPKVPE EIQKQIQDLE KTLDVFNIIL ARQQAQVEVI RSGQKLRKKS
TDTGEKRGGW FSGFWGKKES KKKDEESLIP ETIDDIMTAE EKDKLFTAIG YSESTHNLAL
PKQYVAHIMT LKLVSTSVTI RENQNIPEIL KIQIIGLGTQ VSQRPGAQAL KVEAKLEHWY
ITGLKQEGIV PSLVASIGDT TSSLLKIEFE TNPENSTADQ TLIVQSQPVE VIYDAKTINA
VVEFFQSNKG LDLEQITSAT LMKLEEIKER TATGLTHIIE TRKVLDLRIN LKPSYLILPQ
TGFHHEKSDL LILDFGTFQL NSKDQGLQKT NNSSLEELMD KAYDKFDVEI KSVQLLFARA
EENWKKCRFQ HPSTMHILQP MDIHVELAKA MVEKDIRMAR LKLSGGLPLV HVRISDQKMK
DVLCLINSIP LPQKSPAQSP ERQVSSIPVI SDRTKDLLGT SLLLDGVESE SDDEYFDAED
GDTQTGKSMR GSELKKVAEA PNEELINLLL KFEIKEVVME FTKQQKEEDT ILVFNVTHLG
TEATVRTFDI TVVSYLKKIS LDYHEIQGSR KKPLHLISSS DKPGLDLLKV EYVKADKNGP
SFQTTFEKTE QTLKVAFSSL NLLLQTQALL SSINYLTTII PSDDQRSDTK EVQISDEKQQ
KNLALQKAIV SSKDRDIIDF RLFAKLNAFC VTVCDEKNNI AEIKIQGLDS SLSLQSKKQS
LFARLENIIV TDVDPKTVHK KAVSIMGNEV FHFNLDLYPD ATEGEYYTDM SKVDGVVSLN
VGCIQIVYLH KFLMSLLNFL SNFQTAKEAL SAATAQAAEK AARSVKDLAQ RSFRVSVNID
LKAPVIVIPQ SSISANAVVV DLGLIRVQNQ FSLVSGEDCL NPPVIDRMDV QLTKLKLSRT
VIQPGTSHLD IQLLHPINLE FSVNRNLAAS WYHRVPVVEI KGHLESMNVN LNQEDLNLLF
RILAENLGEA PEDVNKMKPG VQKTGEIKGP LEISTAKQDV HASHGTSIAG VEEMRSVDII
NVLLNFEIKE VVITLMKKAE KKGRPLHELN VLQLGMEAKV KPYDLTAKAY LKKISMRCFE
FSDSVGEPLH IINSSNVTEE PLLKMSLTKA DSDGPEFTTI HDNTKQRLKV SFSSLDLVLH
LEALLSFMDF LSSAVPSSEP SSLEKESSEL KPLVGESRNI VVKAVSSSTS QDDVFDLKVI
AELNAFNVFV CDQKCSIADI RIRGMDASIS VKPKQTDMFA RLKDIVITNV DLLSIHKKAV
SILGDEVFRF QMTLYPDATE GKAYADMSKV DGKLSLKVGC IQIVYVHKFF MSLLNFLNNF
QTAKEALSSA TVQAAERAAS SMKDLAQKSF RLLMDINLKA PVIIIPQSSV SPNAIVADLG
LIRVENKFSL VPMERYSLPP VIDKMNIQLT QLKLSRTLLQ NGLAQPDIEI LKPVNLLLSI
QRNLAAAWYV QIPGMEIKGK LKPMLIALSE DDLTVLMKIL LENLGEASSQ PSPTQTIQEA
IRIRKDVLGG PDHLKEQDLT DSKLSVDQNV TLQFDFHFES LSIVLYNNDI NQESKLSFHN
DSFRLGELRL HLMASVGKMF KDGSMNVSLK LKTCTLDDLR EGIERATSRM IDKKNDQDDN
SSMIDISYKQ SKTGSHIDAI LDKLYVCASV EFLMTVADFF IKAVSQNPEN MAKEAQIPLR
QTATAKVKME KDDSVRPNMT LKAKITDPEV VFVANLTKAD APALTASFQC NLSLSTSKLE
QMMEASVRDL KVLACPFLRE KRGKNITTVL QPCSLFMEKC MWASGKQNIS IMVEEFIIKI
SPIILNTVMT IMAAMSPKTK EDESKDTSKE TENLWGVKPI SDYNSWFLGV DMATEVTENF
KDIQHQSVEE NCAVAVESVQ VTLECGLGHR TVPLLLAESK FSGNIKNWTS LMAATADMTL
EVHYYNETHA VWEPLIERVE GKRPWNLKLD VKKNPVQDRS LMPGDDFIFL PEPQTAVHIS
SGDTMNITIS KSCLNVFSNL AKGFSEGTAS TFDYSLKDRA PFTVKNAVGV PVKVQPNHSL
RVIGSPGKSG VYDVDVGQNL ELEYASMEPS RQGKLSVLSR QESSFFALTF VPHGYTEVAK
VPVARSGRRL YNVRNPNASH SDSVLVQIDA TEGNKVITLR SPLQIKNHFS IAFIVYKSVK
NVKLLERIGV ARPEEEFHVP LDSYRCQLFI QPAGILEDHY KVSTTYISWK EELHRSREVR
CMLQCPSVEV NFLPLIVNTV ALPDELSYIC THEEDWDPAY IIHLYPTLTL RNLLPYSLRY
LLEGTAETHE LAEGSAADVL HSKISGEVME LVLMKYQGRN WSGHFRICDT LPEFFLVCFS
SDSAEVMTID LSIHVRRIGS RMVLSVFSPY WLINKTSRVL QYRSEDIHMK HPADFRDIIL
FSFKKKNIFS KNKVQLKIST SAWSSSFSLD TVGSYGCVKC PANNMEYLVG VSIKMSSFNL
TRIVTLTPFC TIANKSSLEL EVGEIASDGS MPTHKWNYIA SSECLPFWPE NLSGKLCVRV
VGCEGSSRPF FYNRQDNGTL LSLEELNGGI LVDVNIAEHS TVITFSDYHE GSAPALVINH
TSQDVVTYKQ SGSQEEVHLV PGEARLFAWA DPTGTKKLTW TYAANTGEHS LLKDECGQFP
YDANTQIHWV SFLDGRQRVL LFTDDVALVS KALQAEEMEQ ADHEITFSLH SLGLSLVNNE
NKQEVSYIGI TSSGVVWEMK PKQKWKPFSQ KQIMLLEQAY KKYQVSRDHG WIKLDNNFEV
NFDKVPMEMR LPVHCPIKRD FLSGIQIEFK QSPHQRSLRA RLYWLQVDNQ LPGTMFPVVF
HPVAPPKSIA LDSEPKPFID VSVITRFNEY SKVLQFKYFM VLIQEMALKV DQGFLGAIIT
LFTPATDPEA ERKRTKLIQQ DIDALNTELM ETSMTDMSVL SFFEHFHISP VKLHLSLSLG
TGSEESDKEK QEMIAIHSVN LLLKSIGATL TDVDDLIFKL AYYEIRYQFY KRDQLMWSVV
RHYTEQFLKQ MYVLVLGLDV LGNPFGLIRG LSEGVEALFY EPFQGAVQGP EEFAEGLVIG
VRSLFGHTVG GAAGVVSRIT GSVGKGLAAI TMDKEYQQKR REEMGRQPKD FGDSLARGGK
GFLRGVVGGV TGIITKPVEG AKKEGAAGFF KGIGKGLVGA VARPTGGIID MASSTFQGIQ
RAAESTEEVS RLRPPRFIHE DGIIRPYERQ ESEGYDLYEN HIRKLEGETY RYHCAISGSK
KAILMITNRR VLCINEVEIL GHMSIDWQCP FEDFVFPPSV HGNMLKIPVK EQGLFHKKDS
AGYGYRSIYL QDAATAEKAY NAIDDAQSMR QQQKLKKQSS LKLLRPQIPF
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